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Colon Cancer. Cancer Series #26. Featured by Arizona Center for Advanced Medicine. Treating 300+ holistic and medical treatments in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer26

Cancer Series #26 – Colon Cancer.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Colon cancer is the most frequent malignancy of the GI tract, and the second most frequent malignancy diagnosed in recent years. In the mid-1970s, the incidence of colorectal cancer was 60 cases per 100,000 population[1], and about 50% of people survived for 5 years after diagnosis. As of 2004, the incidence of went down to 48 cases per 100,000 population, largely because of increased use of colonoscopy to detect precancerous polyps earlier. It is still the third most commonly diagnosed cancer for both men and women (after breast and prostate). The National Cancer Institute estimates 143,460 people will be diagnosed with colorectal cancer in 2012, with an estimated 51,690 deaths. About one in three people die of their disease every year.

Risk factors for development of colon cancer

Colorectal cancer is associated with inflammation in the GI tract, as has been shown by the increased incidence of colorectal cancer in patients with ulcerative colitis.[2] Certain forms of familial colon cancer are associated with increased expression of the COX-2 inflammatory molecules in the gut.[3] Patients with higher levels of IGF-1 receptors have an increased risk of developing colorectal cancer.[4], [5] Composition of the bacterial flora of the GI tract is also believed to play a role in the development of both inflammatory bowel disease and cancer.[6] Genetics play some role – both in that form associated with polyps, and the form associated with the more difficult to diagnose flat lesions.[7]

Multiple other nutritional and environmental risk factors have been discovered over the years. Animal protein[8], alcohol[9], sugar, high body burden of heavy metals[10] are among the most prominent. At the Arizona Center for Advanced Medicine, we work with nutrition, as well as search for any toxins like heavy metals, which can serve as blocks to healing. Heavy metals are removed through chelation therapy. Nutritional work is part of the protocol of treatment, following the principles outlined in our FirstLine Therapy program.

What is the colon, and what purpose does it serve?

The colon is a muscular tube which originates during the 4th week of embryologic development from the endoderm, one of the outer layers of Cancer26-highlightthe embryo. It is one of the first organs to develop, after the brain. The intestinal tract has layers of smooth muscle, both circular and longitudinal, which serve to propel the food or waste toward its final destination. Between the two layers ride the autonomic nerves which manage both our digestion and our excretion functions without us

having to pay attention to these function. We have striated muscle, under voluntary control, in the mouth, the upper part of the esophagus, and in the lower part of rectum and anus.

The function of the colon is to separate solids from liquids, reabsorb the liquids and eliminate the solids – that which no longer serves the body. In a very real sense, constipation reflects the ability to hold onto the past, or the inability to let go of the past. One of the extraordinary things about the intestinal tract is that whereas much of it is NOT under voluntary control (small intestine, right side of colon), we actually do have voluntary control of both ends – the mouth and the anus.

We can choose what goes in, and we can choose what comes out. We can hold on to things if we so decide. Cancer26-cellsThe holding on may be on a conscious or subconscious levels, but it is under voluntary control. The nerves in those areas have both autonomic and voluntary connections with different kinds of muscle – both smooth and striated. Remember that we are energetic and spiritual beings with physical bodies. What happens on one level happens on all levels. There is a wonderful treatment in Chinese medicine called “External and Internal Dragons”, which is aimed at restoring physical, emotional, mental and spiritual balance to the body. One of the points used is for the colon – to eliminate on all levels those things which no longer serve a useful function, which are holding us back physically and emotionally.

Diagnosis

On physical examination, colorectal cancer may be suspected if we see blood in the stool, or an occult blood test is positive. Many conditions may manifest with blood in the stool, including hemorrhoids, infectious diarrhea, Crohn’s disease, ulcerative colitis, and other inflammatory bowel conditions. Rectal examination may show evidence of a mass if we are dealing with a cancer low in the colon. CT scan or MRI may show X-ray evidence of a mass. Colonoscopy can visualize a polyp or tumor, and allows for biopsy of the mass. However, none of the procedures will give a definitive diagnosis. Only examination of tissue under a microscope provides the diagnosis. Until we see microscopic evidence of abnormal tissue, we only have a suspicion.

Patients are given an estimate of prognosis, based on the staging of the tumor. Staging is based on tumor size in centimeters (T), number of positive lymph nodes (N) and the presence or absence of metastases (M) – this is called TNM staging, with stage one being T0, N0, M0 and stage IV being any size T, any number of N, and presence of metastases.

Cancer26-chartMany efforts have been made to diagnose a cancer without having to get a piece of the tumor surgically. Tumor markers are proteins which are sometimes expressed in high amounts in the circulating blood. If any of the markers is present, that is helpful, because that marker can be usedCancer26-Adamimage as a way to follow success of treatment. However, the presence of a marker does not make the diagnosis, since many other tissues may express the same protein. Nor does the absence of a marker allow us to say that there is no tumor.

Treatment

Standard allopathic treatment of colorectal cancer is primarily surgical, if the tumor can in fact be removed surgically. In more recent years, these tumors have been removed laparoscopically, with good results and much less surgical morbidity – i.e. fewer side effects after surgery, less time spent in hospital, faster resumption of normal bowel function.[11]  Survival after “curative” surgical resection is about 50-60% at 5 years after treatment.[12]

Chemotherapy is generally not recommended, until evidence of recurrence is found – i.e. when the cancer returns. Unfortunately, there is widespread micrometastasis which occurs early in the course of any given cancer, so the potential for metastatic disease and recurrence of cancer is almost always high.[13]

When metastatic disease is found, the aim of surgery is no longer cure, but rather palliation, i.e. helping with relief of symptoms (e.g. intestinal obstruction) without expectation of cure. Under these circumstances, chemotherapy is generally recommended following surgery.

Many chemotherapy regimens have been studied. The most commonly used are FOLFOX (leucovorin, 5-FU and oxiplatin) and FOLFIRI (leucovorin, 5-FU and irinotecan). Addition of monoclonal antibodies further improved the statistical survival, increasing it to a median of about 2 years in those patients with metastatic disease at the time of diagnosis, in those patients with the right genetics.[14]

Is there a way to tell if chemotherapy will be successful? Is the pain worth the gain?

The side effects of conventional chemotherapy are well documented, and anticipated to occur in almost everyone who undergoes chemotherapy. Since the drugs generally work by disrupting rapidly dividing cells (presumably tumor cells), they also disrupt all rapidly dividing cells – in the bone marrow, the mucus membranes of the mouth and intestinal tract, the hair, the skin. Thus the well-known “side effects” of decreased white blood cell count, hair loss, mouth ulcers, diarrhea. Some of the drugs even result in irreversible heart failure (anthracyclines) or respiratory failure (bleomycin) or kidney failure (cisplatin, methotrexate) or neurologic toxicity (cisplatin, vinca alkaloids, taxanes) – sometimes long after the chemotherapy has stopped.

Less conventional chemotherapy has found ways to target the tumor cells without simultaneously targeting all rapidly dividing cells, by utilizing a characteristic of cancer cells which is present to a much lesser degree on non-cancerous cells. Because of their peculiar metabolism, cancer cells are covered with insulin and insulin-like growth factor receptors, so that they can take more than their fair share of glucose from the blood. Donato Perez Garcia, MD discovered in the early 1930s that giving insulin to a patient would allow more antibiotic drugs to penetrate the blood brain barrier. In subsequent years he discovered that the same technique would allow more chemotherapeutic drug to enter cancer cells, thus opening the way for chemotherapeutic treatments that do not risk the destruction of the entire organism. This treatment is called “insulin potentiation therapy”, also known as “low dose chemotherapy” to kill the cancer cells without simultaneously killing all the body’s rapidly-dividing cells. This therapy uses about 1/10 the standard dose of chemotherapeutic agent, driving the chemotherapy into the cells by means of insulin, so that you get the full effect of treatment with very few, if any, side effects. Most patients feel well enough to go out to lunch or dinner after their treatments. 

How do we know which chemo agents to use?

Conventional oncology uses specific drugs for treatment of specific cancers. These drugs are chosen largely on the basis of anecdotal evidence, or through a clinical trial which shows some survival benefit for one regimen over another. Conventional oncology does not generally use the genetic markers of tumor susceptibility (either solid tumors or circulating tumor cells) to determine the choice of therapy. We used to choose antibiotic therapy by that method – what generally works in most people for infection in a specific location – but have for many years now chosen antibiotics based on the susceptibility of the bacterial population in the specific individual who is infected.

At the Arizona Center for Advanced Medicine we use a test for circulating tumor cells[15] in the peripheral blood, called the RGCC™ test.

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Refer to the specific paragraph about 2/3 down the page of the article: “RGCC test for circulating tumor cell count, chemosensitivity and sensitivity to alternative treatments – it is now possible to detect circulating tumor cells (CTC) in the blood stream. A blood sample is sent to a genetic laboratory in Greece. If CTCs are found, they can be grown in tissue culture, and tested against a multitude of chemotherapeutic agents as well as “alternatives” and botanicals, to see which substances have the highest kill rate in tissue culture. This is not a 100% guarantee that it will work on the original tumor, but it’s a pretty good indication – and far better than anything we have available in the United States.” Click here >> http://goo.gl/AZrXP .

This test is helpful for determining both susceptibility of solid tumors (if we have a piece of the tumor to test), and because we know that tumors have a very high potential for metastasizing or spreading, by shedding tumor cells into the circulation. The circulating tumor cells will not always give us any good indication as to their source (i.e. the location or organ of the primary tumor). They will give us an excellent indication as to their sensitivity to standard chemotherapeutic agents and to more natural cancer-fighting compounds.

There is much in the scientific literature to support this approach to therapy.

We tend to think about “cancer” as a single disease, and “colon cancer” as a single entity. We think that all colon cancer cells are exactly the same, and have the same altered genetics which allowed them to escape from physiologic control in the first place. However, it is quite clear from reading the literature that not all tumors are created equal, and not all cells originating in the same tumor have the same genetic expression[17], [16].

K-Ras is a gene associated with GI cancers in a high proportion of patients. K-Ras mutations are found in up to 65–100% of pancreatic carcinomas[18], 3 36% of colorectal cancers, and 20% of non-small cell lung cancers.[19]  The EGFR (epidermal growth factor receptor) is a transmembrane tyrosine kinase that signals through at least 2 parallel intracellular pathways to regulate cellular proliferation and survival. Stimulation of the EGFR receptor results in activation of the RAS gene, resulting in independent function of this gene, and cell proliferation (i.e. neoplastic growth, or cancer).[20]

  • VEGF (vascular endothelial growth factor) promotes angiogenesis (growth of new blood vessels) in response to various conditions: hypoxia, mutant K-Ras, mutant p53 gene, TGF-β.
  • TGF-β regulates proliferation, apoptosis, differentiation and migration of cells.
  • EGFR targeted molecules, cetuximab and panitumumab, have been shown to increase disease-free survival, when given in combination with standard chemotherapy protocols (particularly FOLFIRI AND FOLFOX).[21] Patients with mutant K-Ras did not benefit from this treatment, but patients with wild-type K-Ras benefited significantly.

EGFR targeted molecules, cetuximab and panitumumab, have been shown to increase disease-free survival, when given in combination with standard chemotherapy protocols (particularly FOLFIRI AND FOLFOX).[1] Patients with mutant K-Ras did not benefit from this treatment, but patients with wild-type K-Ras benefited significantly.

The recommendation of the author is to ascertain the K-Ras status prior to initiating treatment with these monoclonal antibodies. The author concludes:

“We are entering an era of personalized medicine in cancer therapy where treatment is tailored to the individual. The predictive value of K-Ras mutations in the treatment of mCRC is very useful to clinicians and patients in terms of decision-making, avoiding toxicities, and decreasing financial burden.”

than utilizing their individual tumor genetics in order to choose an appropriate treatment.[22]

At the Arizona Center for Advanced Medicine, we make full use of all the diagnostic modalities available to us – pathology, radiology, tumor markers, circulating tumor cell analysis – to determine the best individualized treatment for each patient.

How about “alternative” or “natural” therapies?

We use the RGCC™ test again, to determine which particular therapies may be the most helpful. Many things have been used for treatment of cancer over the millennia, in many different ethnic

variations. We use many of them to this day, generally as adjunctive therapies, to improve our treatment results.

Therapy includes not only pharmaceuticals and botanicals, but also (and even more importantly) a focus on prevention of further damage, and repair to the systems which are already damaged or deficient.

The National Cancer Institute’s website states: “Colorectal cancer prevention is a clinical imperative, and a key part of prevention involves the search for drugs that can safely and effectively block or reverse colorectal cancer development.” We certainly agree with the prevention part of the statement. However, it is important to realize that prevention begins LONG before drugs are necessary to control inflammation.

Prevention starts with what goes in to the gut. And prevention can be initiated at any time. Just because you already have colon cancer does not mean it’s too late. Today can be indeed the first day of the rest of your life.

Anti-inflammatory drugs are known to reduce the incidence of GI cancers[23]. However, these Cox-2 inhibitors are also associated with increased cardiovascular risk, so it would appear that drug therapy may not be the best answer.

Adherence to the Mediterranean diet may be the best preventive measure we could possibly take.[24],[25] This nutritional program emphasizes fresh fruits and vegetables, whole grains, and olive oil, with relatively restricted intake of red meats and other animal proteins.

Sugars and starches tend to be highly inflammatory foods, and should be eaten only occasionally, if we wish to avoid inflammation in the gut. Foods to which the individual is allergic or sensitive also are inflammatory. We frequently hear the statement: “My child used to be allergic to milk, but outgrew the allergy.” Of course, the parents do not necessarily make the connection between “growing out of the food allergy” and the development of asthma or symptoms of ADHD, which may be simply deeper more serious manifestations of the original sensitivity.

Fruits and vegetables contain nutrients which our bodies need, and are seldom inflammatory. Red meats are considered “hot” in Chinese medicine, and are more inflammatory than poultry or fish.

Probiotics will help to restore the normal gut flora which antibiotics have often destroyed.  In addition, they reduce inflammation in the gut, and sometimes even help to potentiate certain forms of chemotherapy.[26]

Alternative therapies to modulate the immune system, decrease excessive cell growth, and kill cancer cells

Many natural and “alternative” (i.e. non-chemotherapeutic) treatments are used.

Resveratrol, a compound isolated from the skin of red grapes, which is reported to decrease the excessive growth of colon cancer cells, but is also reported to increase resistance to the chemo drug taxol. [27],[28],[29],[30]

Vitamin D [31],[32] - appears to have protective activity against colo-rectal carcinoma. We know that Vitamin D can induce cell differentiation (i.e. help cells grow up) and apoptosis (i.e. help cells die when they are damaged), as well as inhibiting excessive cell division, new blood vessel formation, and spread of tumor cells. There are vitamin D receptors in the colon and rectum.

Citrus aurantium (Sour orange) [33]

Vitamin A [34],[35]

Curcumin 26,[36],[37],[38],[39]

Medicinal mushrooms – there is extensive literature for all these, I have included only a small sample.

Vitamin C- has a long an honorable history of being healthy for the body in many ways, cancer among them[63],[64]. Dr. Linus Pauling was the initial proponent of the use of high doses of Vitamin C to maintain health. Vitamin C is both an anti-oxidant and a pro-oxidant, depending on the dose. When we use it to treat cancer, we use it as a pro-oxidant in high doses intravenously.[65],[66],[67]

Mistletoe – Iscador – extracts of the mistletoe plant have been used for centuries in treatment of cancer. Their mechanisms of action are beginning to be elucidated by the scientific community. Iscador has a modulating effect on natural killer cells[68], and has benefit along with chemotherapy to patients with pancreatic  and other forms of cancer.[69],[70],[71]

Poly-MVA – a supplement first patented in 1991, using a lipoic acid-palladium complex, together with other specific vitamins and nutrients. It has a remarkable anti-oxidant effect, and is able to restore function to mitochondria which have been damaged by oxidative stress, thus restoring cellular function to normal cells.[72],[73] In addition, once cancerous cell mitochondria start to function normally, they suddenly are able to use oxygen for metabolism, so either the mitochondrial byproducts kill the anaerobic (cancer) cells, or the cell’s normal function is restored. Either way, the supplement helps cancer patients go into remission, with practically no unwanted side effects. This supplement can be given orally or intravenously. An excellent description of the product, and its use in prostate cancer, can be read on the Poly-MVA website.

And, in the end, the filters have to be cleaned up before the cancer can be healed.

Call us at 480-240-2600 for further information about treatment of your cancer, using nutritional therapy, supplements, body work, mind work, integrative cancer treatments and low dose chemotherapy. Our doctors offer a free 15-minute consultation, so that you can determine whether this is the best place for your treatment.

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See much more information on the Arizona center for Advanced Medicine Website Resource Library, click here >> http://goo.gl/p4qbh .

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References:

[1] National Cancer Institute, http://www.cancer.gov/cancertopics/cancer-advances-in-focus/colorectal downloaded June 12, 2010.

[2] A Ekbom, C Helmick. Ulcerative colitis and colorectal cancer. A population-based study. NEJM 18; 323:1228-1233 (November 1, 1990).

[3] TsunozakiH, YoshinagaK et al. Cyclooxygenase-2 Overexpression in Colorectal Cancer is Associated with Non-polypoid Growth. Japanese Journal of Clinical Oncology 32:167-171 (2002).

[4] Feik E, Baierl A. Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control. 2010 Jan;21(1):91-7.

[5] Ma, Jing, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. JNCI, Vol. 91, April 7, 1999, pp. 620-25

[6] Hirayama K, Baranczewski P et al.  Effects of human intestinal flora on mutagenicity of and DNA adduct formation from food and environmental mutagens . Carcinogenesis, Vol. 21, No. 11, 2105-2111, November 2000. © 2000.

[7] Lynch HT, de la Chapelle A. Hereditary Colorectal Cancer. NEJM 10;348:919-932.

[8] Toden S, BirdAR et al.High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch. Carcinogenesis. 2007 Nov;28(11):2355-62.

[9] Yi SW, Sull JW et al. Alcohol consumption and digestive cancer mortality in Koreans: the Kangwha Cohort Study. J Epidemiol. 2010 May 5;20(3):204-11.

[10] Farah IO, Trimble Q et al. Significance of differential metal loads in normal versus cancerous cadaver tissues – biomed 2010. Biomed Sci Instrum. 2010;46:404-9.

[11] Lacy A, Garcia J et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial.  Lancet. 2002 Jun 29;359(9325):2224-9.

[12] Skeel RT, ed. Handbook of Cancer Chemotherapy. 7th edition. © 2007, Lippincott Williams & Wilkins, Philadelphia, PA. ISBN 978-0-7817-6531-2. (page 271).

[13] Oakman C, Pestrin M et al. Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer. Cancers 2010, 2(2), 1221-1235; doi:10.3390/cancers2021221.

[14] Saif MW. K-Ras mutations in colorectal cancer: A Practice Changing Discovery. Clinical Advances in Hematology & Oncology Volume 7, Issue 1 January 2009.

[15] Cristofanilli M, Budd T et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer. NEJM 351;824-26.

[16] Molnar B, Ladanyi A et al. Circulating Tumor Cell Clusters in the Peripheral Blood of Colorectal Cancer Patients. Clinical Cancer Research  (December 2001); 7: 4080-85.

[17] Cristofanilli M, Budd T et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer. NEJM 351;824-26.

[18] Levi S, Urbano-Ispizua A, Gill R. Multiple K-Ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res. 1991;51:3497-3502

[19] Raponi M, Winkler H, Dracopoli NC. K-RAS mutations predict response to EGFR inhibitors. Curr Opin Pharmacol. 20078;8:413-418.

[20] Saif MW. K-Ras mutations in colorectal cancer: A Practice Changing Discovery. Clinical Advances in Hematology & Oncology Volume 7, Issue 1 January 2009.

[21] ibid

[22] American Society of Clinical Oncology Technology Assessment: Chemotherapy Sensitivity and Resistance Assays. Downloaded June 12, 2010. Originally published in J Clin Oncology 22;17 (September 1), 2004: pp. 3631-3638.

[23] Arber N. Cyclooxygenase-2 Inhibitors in Colorectal Cancer Prevention. Cancer Epidemiology, Biomarkers & Prevention August 2008 17; 1852. doi: 10.1158/1055-9965.EPI-08-0167.

[24] Mantzoros CS, Williams CJ et al. Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. American Journal of Clinical Nutrition, Vol. 84, No. 2, 328-335, August 2006.

[25] Barb D, Williams CJ et al. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr. 2007 Sep;86(3):s858-66.

[26] Baldwin C, Millette M et al.  Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis. Nutr Cancer. 2010 Apr;62(3):371-8.

[27] Vanamala J, Reddivari L et al. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer 2010, 10:238doi:10.1186/1471-2407-10-238

[28] Mao QQ, Bai Y et al. Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines. Mol Nutr Food Res. 2010 Jun 2.

[29] Vanamala J, Reddivari L et al. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 2010 May 26;10(1):238.

[30] Matić I, Zižak Z et al. Cytotoxic Effect of Wine Polyphenolic Extracts and Resveratrol Against Human Carcinoma Cells and Normal Peripheral Blood Mononuclear Cells. J Med Food. 2010 May 18.

[31] Krishnan AV, Trump DL et al. The role of vitamin D in cancer prevention and treatment. Endocrinol Metab Clin North Am. 2010 Jun;39(2):401-18.

[32] Takahashi R, Mizoue T et al. Circulating vitamin D and colorectal adenomas in Japanese men. Cancer Sci. 2010 Mar 23.

[33] Jayaprakasha GK, Jadegoud Y et al. Bioactive compounds from sour orange inhibit colon cancer cell proliferation and induce cell cycle arrest. J Agric Food Chem. 2010 Jan 13;58(1):180-6.

[34] Farah IO, Trimble Q et al. Retinoids and citral modulated cell viability, metabolic stability, cell cycle progression and distribution in the a549 lung carcinoma cell line – biomed 2010. Biomed Sci Instrum. 2010;46:410-21.

[35] Kikuchi H, Kuribayashi F et al. Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells. Biochem Biophys Res Commun. 2010 Apr 23;395(1):61-5.

[36] Suphim B, Prawan A et al. Redox Modulation and Human Bile Duct Cancer Inhibition by Curcumin. Food Chem Toxicol. 2010 May 24.

[37] Ide H, Tokiwa S et al. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate. 2010 Jul 1;70(10):1127-33.

[38] Watson JL, Hill R et al. Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Cancer Lett. 2010 May 14.

[39] Hilchie AL, Furlong SJ et al. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria.  Nutr Cancer. 2010 Apr;62(3):379-89.

[40] Gonzaga ML, Bezerra DP et al.  In vivo growth-inhibition of Sarcoma 180 by an alpha-(1–>4)-glucan-beta-(1–>6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. J Nat Med. 2009 Jan;63(1):32-40.

[41] Itoh H, Ito H et al.  Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. Oncol Rep. 2008 Dec;20(6):1359-61.

[42] Firenzuoli F, Gori L et al. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

[43] Angeli JP, Ribeiro LR et al.  Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes. Cell Biol Toxicol. 2006 Jul;22(4):285-91.

[44] Wan JM, Sit WH et al. Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells. Chin Med. 2010 Apr 27;5:16.

[45] Wan JM, Sit WH et al. Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol. 2008 Mar;32(3):689-99.

[46] Jiménez-Medina E, Berruguilla E et al. The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer. 2008 Mar 24;8:78.

[47] Bisen PS, Baghel RK et al. Lentinus edodes: A Macrofungus with Pharmacological Activities. Curr Med Chem. 2010 May 24.

[48] Kawanishi T, Ikeda-Dantsuji Y et al. Effects of two basidiomycete species on interleukin 1 and interleukin 2 production by macrophage and T cell lines. Immunobiology. 2010 Jul;215(7):516-20.

[49] Yu S, Weaver V et al. The effects of whole mushrooms during inflammation. BMC Immunol. 2009 Feb 20;10:12.

[50] Jedinak A, Sliva D. Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. Int J Oncol. 2008 Dec;33(6):1307-13.

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[52] Lee JS, Park SY et al. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. Exp Mol Med. 2010 Feb 28;42(2):143-54.

[53] Masuda Y, Matsumoto A et al. Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa. J Agric Food Chem. 2009 Nov 11;57(21):10143-9.

[54] Chang YH, Yang JS et al.  Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo. Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94.

[55] Dudhgaonkar S, Thyagarajan A et al. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int Immunopharmacol. 2009 Oct;9(11):1272-80.

[56] Weng CJ, Chau CF et al. Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models. J Agric Food Chem. 2009 Jun 10;57(11):5049-57.

[57] Kim HS, Kim JY et al. Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem Toxicol. 2010 Apr 29.

[58] Kim HG, Song H et al. Cordyceps pruinosa extracts induce apoptosis of HeLa cells by a caspase dependent pathway. J Ethnopharmacol. 2010 Mar 24;128(2):342-51.

[59] Jordan JL, Nowak A et al. Activation of innate immunity to reduce lung metastases in breast cancer. Cancer Immunol Immunother. 2010 May;59(5):789-97.

[60] Tsuji T, Du W et al. Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice. PLoS One. 2010 Mar 31;5(3):e9885.

[61] Sliva D, Jedinak A et al. Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer. 2008 Apr 22;98(8):1348-56.

[62] Zhu T, Guo J et al. Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer. 2007 Feb 26;96(4):583-90.

[63] Hopkins MH, Fedirko V et al. Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial. Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):850-8.

[64] Miranda CL, Reed RL et al. Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chem Res Toxicol. 2009 May;22(5):863-74.

[65]Ullah MF, Khan HY et al. The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer. Cancer Chemother Pharmacol. 2010 Mar 6.

[66] Frei C, Lawson S. Vitamin C and Cancer Revisited. Proc Natl Acad Sci August 12, 2008   vol. 105  no. 32  11037-11038

[67] Chen Q, Espey MG et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008 August 12; 105(32): 11105–11109.

[68] Braedel-Ruoff S. Immunomodulatory effects of Viscum album extracts on natural killer cells: review of clinical trials. Forsch Komplementmed. 2010;17(2):63-73.

[69] Matthes H, Friedel WE et al. Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Curr Mol Med. 2010 Jun;10(4):430-9.

[70] Augustin M, Bock PR et al. Safety and efficacy of the long-term adjuvant treatment of primary intermediate- to high-risk malignant melanoma (UICC/AJCC stage II and III) with a standardized fermented European mistletoe (Viscum album L.) extract. Results from a multicenter, comparative, epidemiological cohort study in Germany and Switzerland. Arzneimittelforschung. 2005;55(1):38-49.

[71] Friedel WE, Matthes H et al. Systematic evaluation of the clinical effects of supportive mistletoe treatment within chemo- and/or radiotherapy protocols and long-term mistletoe application in nonmetastatic colorectal carcinoma: multicenter, controlled, observational cohort study. J Soc Integr Oncol. 2009 Fall;7(4):137-45.

[72] Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV. Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats. Food Chem Toxicol. 2010 Jul;48(7):1858-62. doi: 10.1016/j.fct.2010.04.022.

[73] Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV. Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats. Food Chem Toxicol. 2009 Aug;47(8):2124-8. doi: 10.1016/j.fct.2009.05.032.

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View the entire Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/VFLmD.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

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Natural cancer treatment – par excellence! Cancer Series #25. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600

Cancer25Header

Agaricus brasiliensis (aka blazei) murill – Natural cancer treatment par excellence.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

History – Agaricus brasiliensis murill (ABM) is native to Brazil, where it is known as Cogumelo do sol. In Japan it is called Himematsutake, Cancer25-fig1Agarikusutake or Kawarihiratake and in China Ji Song Rong.[1]It was discovered in 1960 by a Japanese researcher, Takatoshi Furumoto and sent to Japan for investigation.[2] It has been studied as a functional food and medicinal product. Its use as a medicinal product was first described around the 4th century A.D. as a treatment for malignant ulcers of the larynx.[3] In modern times it is used as anti-oxidant[4], anti-diabetic[5], cholesterol-lowering[6], anti-cancer[7],[8], immunomodulatory[9], anti-allergic[10], kidney protective[11], and anti-microbial agent[12].

The anti-tumor effects, more specifically, include reactive oxygen species inducer[1], anti-mitotic[2], angiogenesis inhibitor[3], topoisomerase inhibitor[4], leading to apoptosis[5], and eventually checking cancer proliferation.

Extracts of ABM appear to exert a significant effect on the immune system.[6] They activate white blood cells, macrophages, neutrophils and lymphocytes  – cells which are crucial in recognition and destruction of circulating tumor cells. These are all part of our general defense system – the guards at the gate, which we call the innate immune system.

The innate immune system is present at birth. It responds to foreign invaders – mainly microbial – in a relatively non-specific fashion. It does not make specific antibodies. Rather it recognizes certain patterns present in bacteria, leading the macrophages to surround and destroy the bacteria. The innate immune system is also crucial in the recognition of abnormal cells – cancer cells – which it normally engulfs and destroys.Once a virus or bacterium penetrates the skin (or the mucus membranes) a local infection results, causing tissue damage which, in turn, causes the tissue macrophages to call for help by secreting specific cytokines. These cytokines call for more immune cells which then surround the pathogens and destroy them.

The Complement cascade is activated, manufacturing C3a and C5a to attract yet more white cells to the area, along with fluid from the capillaries. The cytokines, when they reach the liver, cause the manufacture of acute phase proteins (sometimes called heat shock protein). Body temperature is raised, and NK (Natural Killer) cells are activated to destroy virus-infected cells. Interferon alpha and beta are secreted to make nearby cells more resistant to viral infection.

Cancer25-fig2

For all that Agaricus brasiliensis has so many health effects, it is a fastidious and demanding species, and must be picked within a few hours of the fruiting body maturing. The glucan content increases as the fruiting body matures, so the time of harvest is of great importance, and explains (in part) the cost of the best supplements of the mushroom.[1]

The quality of the mushrooms themselves is another important consideration. In 2006 the Japanese ministry of health decided to recall Cancer25-mushroomsproducts containing Agaricus brasiliensis because of a suspicion that the mushroom could induce the development of liver failure and cancer.[2] After extensive testing, it was determined that those mushrooms which grew in polluted urban areas of China did indeed induce liver cancer in mice[3], but that the mushrooms grown in non-polluted areas had no such effect. In fact, the agaricus species that were tested had such high mercury concentrations, one wonders whether that species is attempting to protect the environment by absorbing the toxic mercury.

The quantity of beta-d-glucan in a mushroom product depends on the quality and grade of the mushroom. Most ABM mushrooms grown outside of Brazil range from 3 to 4 %. In its natural environment, the ABM mushroom can contain up to 7% d-glucan on average. Ultra Gold quality ranges above 4.8%. Companies

selling ABM mushrooms claiming to contain 45% or more beta-D-Glucan are selling a manufactured standardized product, where Beta-D-Glucan has been added because 45% in nature does not exist.

Both alpha and beta glucans enhance the immune system, both have anti-tumor activity, and both appear in larger quantities as the fruiting body matures.[1]

(Click on the image to make larger.)

Cancer25-group

Hear from an Arizona Center for Advanced Medicine cancer patient below…

Sources:

[1] F. Firenzuoli, L. Gori, and G. Lombardo. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

[2] Firenzuoli F, Gori L, Lombardo G. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 Mar;5(1):3-15. doi: 10.1093/ecam/nem007.

[3] RamoutsakiIA, Helidonis ES, et al. Therapeutic methods for otolaryngological problems during the bzantine period.  Ann Otol Rhinol Laryngol 2002;111:553–7.

[4] Oliveira OM, BrunettiIL et al.Antioxidant activity of Agaricus blazei. Fitoterapia. 2007 Apr;78(3):263-4.

[5] Hsu CH, Chou P et al. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102.

[6] Kweon MH, Park YI et al. Lowering effects in plasma cholesterol and body weight by mycelial extracts of two mushrooms: Agaricus blazai and Lentinus edodes. Korean Journal of Microbiology and Biotechnology 2002;30(4):402-9.

[7] Fan MJ, Chung JG, et al. Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway. In Vivo. 2011 May-Jun;25(3):355-66.

[8] Pinto AV, Kaneno R et al. Polysaccharide fraction of Agaricus brasiliensis avoids tumor-induced IL-10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma. Cell Immunol. 2009;256(1-2):27-38. doi: 10.1016/j.cellimm.2009.01.002.

[9] TangNY, Chung JG et al. Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice. In Vivo. 2009 Sep-Oct;23(5):761-6.

[10] Ellertsen LK, Hetland G. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clin Mol Allergy. 2009; 7: 6. doi:  10.1186/1476-7961-7-6  

[11] Dalla Santa HS, Soccol CR et al. Kidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (=Agaricus blazei, Agaricus subrufescens) Produced by Solid State Cultivation. OnLine Journal of Biological Sciences 9 (1): 21-28, 2009

[12] Valadares DG, Coelho EA et al. Prophylactic or therapeutic administration of Agaricus blazei murill is effective in treatment of murine visceral leishmaniasis.Exp Parasitol. 2012 Jul 20.

[13] Bernardshaw S, Johnson E et al. Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo. APMIS. 2007 Jun;115(6):719-25.

[14] Jiang SM, Xiao ZM, Xu ZH. Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor. World J Gastroenterol. 1999 Oct;5(5):404-407.

[15] Niu Y.C. Wu XX et al. A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo. Oncol Rep. 2009 Jan;21(1):145-52.

[16] GrynbergNF, Braz-Filho R, et al. DNA topoisomerase inhibitors: biflavonoids from Ouratea species. Braz J Med Biol Res 2002; 35: 819-822.

[17] Kim MO, Kim GY et al. Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells. Evid Based Complement Alternat Med. 2011:838172. doi: 10.1093/ecam/nep176.

[18] Huang TT, Lai HC et al. The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1β Production and Activates the NLRP3 Inflammasome in Human Macrophages.PLoS One. 2012; 7(7):e41383. Epub 2012 Jul 23.

[19] Camelini CM, Tavares LA et al. Structural characterization of beta-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Lett. 2005 Sep;27(17):1295-9.

[20] Mukai H, Katsumata N et al. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol. 2006 Dec;36(12):808-10.

[21] Chen XH, Qui GZ et al. Analysis of several heavy metals in wild edible mushrooms from regions of China. Bull Environ Contam Toxicol. 2009 Aug;83(2):280-5. doi: 10.1007/s00128-009-9767-8.

[22] Camelini CM, Tavares LA et al. Structural characterization of beta-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Lett. 2005 Sep;27(17):1295-9.

[23] F. Firenzuoli, L. Gori, and G. Lombardo. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Integrative Cancer Care. Cancer Series #22. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer22

The Exclusive Cancer Series #22 – Integrative Cancer Care.

Important information cancer patients and their families should know.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Chemo, surgery, radiation – this is the mantra of current recommendations for cancer therapy. Treatment options on the website of the Mayo Cancer18-BestAnswerLogoClinic, “the most innovative, progressive care anywhere” are the following: bone marrow transplantation, chemotherapy, radiation therapy and radio frequency ablation.[1]

And yet… the incidence of cancer is projected to rise 75% by the year 2030.[2] What is wrong with this picture?

Insulin potentiation chemotherapy, low dose

The National Cancer Institute describes side effects of conventional chemotherapy on its website.[3]Cancer18-vomit

Some common side effects from chemotherapy are fatigue, nausea, vomiting, decreased blood cell counts, hair loss, mouth sores, and pain… Sometimes, chemotherapy causes long-term side effects that do not go away. These may include damage to your heart, lungs, nerves, kidneys, or reproductive organs. Some types of chemotherapy may cause a second cancer years later.

The website does not mention death from destruction of the immune system and systemic infection.

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View an entire article on Insulin potentiation chemotherapy at our website, click here >> http://goo.gl/gaXOZ .

Chemotherapy is actually pretty effective for a few cancers.4 Greater than 10% survival can be attributed to cytotoxic chemotherapy in the following cancers: cervix 12%, ovary 8.7%, testicle 41.8%, Non-Hodgkins Lymphoma 10.8%, Hodgkins Lymphoma 35.8%. Breast cancer gets only 1.5% survival increase from chemotherapy, colon cancer 1.8%, brain cancer 4.9%.

Why are we so quick to put conventional chemotherapy first on the list for cancer treatment? Graeme Morgan, an Australian radiation oncologist, writes: “For most patients, the use of cytotoxic chemotherapy is for the palliation of symptoms and to improve quality of life.” However, Dr. Morgan concludes: ““The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.” [1]

If conventional chemotherapy were less toxic, it might be worth it. But for a 2.5% benefit? It is hard to discern the advantages.

Most people are not aware that there is a gentler form of chemotherapy, known as Insulin Potentiation Therapy, low dose.[2],[3] This therapy is just as effective as standard chemo, without all the painful and sometimes lethal side effects. Insulin is used to lower the blood sugar, resulting in relatively increased starvation of cancer cells which require more sugar than normal body cells. Once the blood sugar is sufficiently low, sugar is given intravenously, along with a small dose of chemo (about 10-15% the usual dose). The chemo is sucked into the cells, along with the sugar, and concentrates in cancer cells because they are so much more avid for sugar than normal cells.[4],[5]

With IPT, the incidence of so-called side effects is markedly decreased. Most of our patients drive themselves home from treatment. They may report a little fatigue on the day of treatment. Seldom do they lose any hair at all, and they hardly ever drop their white blood cell counts. They are able to lead normal lives during the course of their IPT therapy.

View the FREE video below describing I.P.T. therapy at Arizona Center for Advanced Medicine…

If our therapies are so effective, why is the incidence of cancer projected to rise so dramatically? And why are the therapies in fact not effective Cancer18-Fig1for every form of cancer?

Our bodies are full of toxins – chemicals from our foods and from the air we breathe, artificial colorings and flavorings, artificial sweeteners (like chlorinated hydrocarbons, or pesticides), high levels of sugar with consequent high levels of insulin, or even frank diabetes. So it is not surprising that mutations can occur. That is the essence of cancer. The cells mutate to a lower state of being, one where they are only concerned with growth, and not with the good of the entire organism.

Insulin Potentiation Therapy – even low dose – is NOT ENOUGH to treat cancer, any more than chemotherapy by itself is a sufficient treatment. For truly integrative cancer therapy, many different modalities are brought into play.

It is helpful to know which chemotherapy to use – which actually kills your cancer cells, not just which has been studied and had a good effect on 30% or 50% of people in whom it was tried. It is equally helpful to know which complementary – botanical and supplemental – therapies could be therapeutic.

Chemosensitivity testing is available – but not in these United States, unfortunately.  We use a laboratory in Greece, run by an oncologist, to determine which drugs and which supplements to use for the greatest effect. 

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View more information on the Greek RESEARCH GENETIC CANCER CENTRE LTD methods, click here >> cancer18-Fig2http://goo.gl/hEh1F , and scroll about half way down the page.

  • We use standard chemotherapeutic agents – and sometimes even standard combinations as recommended in the current oncology literature.[1]
  • We use botanical remedies like Iscador[2], and supplements like high dose Vitamin C[3] (but not if bortezomib is part of the regimen chosen[4], lipoic acid[5], glutathione[6] and many others, to restore the function of natural killer cells, and to bring the body back to a state where it can defend itself against the foreign cancer cell invaders.
  • We teach our patients the basics of a healthy diet – encouraging mainly plant-based foods[7] in  the early phases.
  • We test for nutrient deficiencies, and administer nutrient IV therapies to replenish the body’s stores.Cancer18-Fig3
  • We work with our patients to help them dismantle barriers to healing – old dogma, old conflicts, old beliefs, old injuries, physical or emotional, which they have been unable to see or unwilling to give up.

View more information on the Arizona Center for Advanced Medicine website…

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View more information on basics of a healthy diet, click here >> http://goo.gl/HrAjT .

View more information on nutrient IV therapies, click here >> http://goo.gl/2usMN .

View more information to dismantle barriers to healing, old beliefs, click here >> http://goo.gl/nUdhX .

Cancer18-beliefLEFT

As with any medical therapy, it is unwise to throw out everything, because each form of therapy has its use. Chemotherapy does indeed kill many cancer cells. High dose Vitamin C kills many others. Anti-inflammatory supplements and spices help to restore balance to the immune system. Cancer18-textgraphicNutrients help to sustain the body in its battle. And release of old stuff helps to restore the soul to a place of gratitude and love.

Every modality plays a part in our therapies. We are honored to share the journey with our patients. We would prefer to share the journey earlier in its course rather than later, when the immune system is already gone, and the body is in desperate straits.

Standard chemotherapy is like a bomb exploding, creating collateral damage to the organism.

Insulin Potentiation Therapy, when combined with Integrative and Functional Medicine Therapy, is a lifeline to help restore physical function and enable the body to heal.

Hear from an actual Cancer patient in the video below…

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For more information about our integrative cancer care, please visit the website, click here >> http://goo.gl/oMoAu.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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Sources:

[1] Downloaded 12/2/2012 from http://www.mayoclinic.org/cancer-treatment/diseases.html

[2] Bray F, Jemal A, Forman D et al. Global cancer transitions according to the Human Development Index (2008—2030): a population-based study. The Lancet Oncology, Volume 13, Issue 8, Pages 790 – 801, August 2012

[3] Downloaded 12/2/2012 from http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you/page5

[4] Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.

[5] http://www.arizonaadvancedmedicine.com/therapies/IPT_therapy.html

[6] http://www.bestanswerforcancer.org/what-is-insulin-potentiation-therapy-low-dose-iptld/

[7] Raffaghello L, Safdie F, Longo VD et al. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15;9(22):4474-6.

[8] Lee DH, Raffaghello L, Longo VD et al. Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Sci Transl Med 7 March 2012: Vol. 4, Issue 124, p. 124 – 27

[9] Chu E, DeVita VT. Physicians’ Cancer Chemotherapy Drug Manual (updated every year). © Jones & Bartlett Learning, LLC. ISBN 978-1-4496-4683-7.

[10] Strüh CM, Jäger S, Martin SF et al. A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells. Phytother Res. 2012 Feb 8. doi: 10.1002/ptr.4604.

[11] Frei B, Lawson S. Vitamin C and Cancer Revisited. PNAS August 12, 2008 vol. 105 no. 32

[12] Perrone G, Hideshima T, Anderson KC et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia. 2009 Sep;23(9):1679-86.

[13] Zachar Z, Marecek J, Bingham PM et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

[14] Singh S, KhanAR, GuptaAK. Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol. 2012;9(4):303-16.

[15] Campbell TC, Campbell II TM. The China Study. © 2006, BenBella Books. ISBN 978-1932100-66-2

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Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Oral cancer – Early detection test now available. Cancer Series #21. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. call 480-240-2600.

Cancer21

The Exclusive Cancer Series #21. Oral cancer – Early detection test now available.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

It is estimated by the National Institutes of Health (NIH)[1] that 12,770 people (three times more men than women) will be diagnosed with tongue cancer, and that about 2000 of them will die of their disease. About 8% of those afflicted are under the age of 45. 40% are over the age of 65.Cancer21-FdnSymbol

The tongue is not the only organ in the mouth – just the most visible. 40% of oral cancers are found in the tongue; the lips and floor of the mouth account for another 35%.[2] It is estimated that 40,250 people (again three times more men than women) will be diagnosed with cancer of the oral cavity and throat, and that about 7800 of them will die of their disease. The lips and the floor of the mouth are the next most frequent sites of disease.

Lifetime risk is about one in 100 – about the same incidence as autism. The incidence is increasing, with an 11% jump in 2007 alone.[3]

Three main causes of oral cancer are “smokeless” tobacco (snuff or chew), alcohol, and Human Papilloma Virus (HPV), presumably acquired through oral sexual intercourse. Non-smoking patients under the age of 50 are the fastest growing segment of the population in which oral cancer is diagnosed. Most of these cancers are found by dentists during the course of routine examination.Cancer21-oraldrawing

The NCI website states: “There is no standard or routine screening test for oral cancer.”[4]

Over half of oral cancers have already spread to the lymph nodes by the time they are seen and diagnosed. If found early, the 5 year survival is 80-90%. With spread to the lymph nodes, 5 year survival decreases to 45%.[5]

Any non-healing sore in the mouth or on the lips should prompt a visit to your dentist for examination. Your physician can also examine your mouth and tongue, but your dentist has the better tools to examine the entire oral cavity.

Screening tests have been developed. One commercially available test involves rinsing the mouth with a blue dye, then illuminating the oral cavity with a special light.[6] The following images were downloaded from the website of the company which makes the device.[7]

Cancer21-OralTongue

Cancer21-AdvancedAnother test involves using salivary markers both for diagnosis and for survival estimates.[1],[2] This test is also now available commercially[3] It is based on good research published in the peer-reviewed literature, although it has not yet been validated by multiple studies.

At the Arizona Center for Advanced Medicine we use every modality available to us to provide truly integrative care for our patients with cancer.

Please view these additional webpage’s provided by Arizona Center for Advanced Medicine with additional information on cancer treatment…

Nutrition is crucial – a low carbohydrate low animal protein diet appears to be the most successful for patients with a diagnosis of cancer.

View food nutrition articles on our website, click here >> http://goo.gl/byFUW and http://goo.gl/llq2C .

Supplementation of vital nutrients – we measure those nutrients (vitamins, mineral, fatty acids) and replace those which are functionally deficient in the individual patient. We don’t just look at population based numbers because everyone has different needs, and requires different amounts of the nutrients, based on their genetics. We use both oral and intravenous supplements to fill in the big nutritional potholes and provide the body with what it needs to heal.

View food Supplementation articles on our website, click here >> http://goo.gl/zA821 and http://goo.gl/dGrNC .

Chemo- and Botanical Sensitivity Testing to determine which drugs, supplements, botanicals and other therapies have the best kill rate of circulating tumor cells – those cells which are responsible for metastasis of the tumor (distant spread) and which will eventually lead to the patient’s death.

View article, for the section entitled The Cellular Genetics Test  scroll half way down this page, click here >> http://goo.gl/mST5W .

Integrative cancer treatments – using botanicals, supplements and specific nutrients which have been shown to be helpful both in prevention and in treatment of cancer.

View our Integrative Cancer Treatment article, click here >> http://goo.gl/6I38T .

Bioenergetic modalities – to help pinpoint and treat the root cause of the cancer, whether it be physical or emotional toxin, so that any blocks to healing may be removed, and true healing may occur.

View our website article on Energy Medicine, click here >> http://goo.gl/zrx2K .

Insulin potentiation therapy – chemotherapy at low dose, potentiated by insulin, to destroy the cancer cells without destroying the immune system, the intestinal tract, the blood, the hair… We choose drugs based not only on standard therapy, but also on the results of specific chemosensitivity testing of circulating tumor cells.

View our article on Insulin Potentiation Therapy (IPT), click here >>  http://goo.gl/mST5W .

View a video on IPT treatment at Arizona Center for Advanced Medicine below…

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g

Please view these additional webpage’s provided by Arizona Center for Advanced Medicine with additional information on these relative subjects…

Nutrition:

Food 201 – Is Organic Really Better? Cancer21-USDA

You can point to different studies that argue about the extra nutritional value of Dr. Marion Nestle, chairwoman of the department of nutrition, food studies and

View the entire Food 201 article, click here >> http://goo.gl/UkC6I .

FOOD 101 – Genetics, Addiction, and PoliticsCancer21-adboards

Nutrition decisions based largely on studies funded by the processed food industries gave birth Nutrition “experts” went with the flow and spread the message.

View the entire Nutrition article on our website, click here >> http://goo.gl/wWhVf .

Genetically Modified FoodGMOfilmCoverW

In addition to their potential to produce hard-to-detect allergies and nutritional problems, the scientists said that “The possibility of unexpected, accidental

View the entire website article on “Genetically Modified Food”, click here >> http://goo.gl/1eumZ .

Nutritional IV Therapies.Cancer21-chemo

Nutritional IV Therapies. IV therapy can be more effective than taking supplements orally for correcting intracellular nutrient deficits. The intravenous methods

View the entire website article “Nutritional IV Therapies”, click here >> http://goo.gl/dde02 .

Supplementation:

Safety Net I and II Supplements.Cancer21-Suppliments

You want supplements with the upmost potency and quality, but they can be expensive and time consuming to organize. I asked a master formulator to combine

View the entire Supplements article on our website, click here >> http://goo.gl/yfvhh .

Nutritional IV Therapies.Cancer21-IVnutrition

Nutritional IV Therapies. IV therapy can be more effective than taking supplements orally for correcting intracellular nutrient deficits. The intravenous methods

View the entire website article “Nutritional IV Therapies”, click here >> http://goo.gl/dde02 .

Chemosensitivity testing:

Colon Cancer.Cancer21-Intestines

Declare the one-size-fits-all approach (sometimes called “cookbook medicine”) obsolete and do chemo-sensitivity testing for each individual patient to determine …

View the entire article on our website, click here >> http://goo.gl/HaKrm .

Melanoma | Skin Cancer.Cancer21-Lady

The study questioned whether this might not be a useful way of determining chemosensitivity.[22] In other words, let’s custom design the chemotherapy to attack …

View the entire Melanoma article on our website, click here >> http://goo.gl/BQhV6 .

Insulin Potentiation Therapy for Cancer | IPT:

Insulin Potentiation Therapy for Cancer | IPTCancer21-MRI

He has developed a way of isolating circulating tumor cells from peripheral blood , growing them in cell culture, and testing them for chemosensitivity, as well as …

View the entire article on our website on IPT, click here >> http://goo.gl/3xSla .

Arizona Center for Advanced Medicine – Martha M. Grout, MD, MD(H)DrGroutW

IPT is a targeted, low dose chemotherapy combined with complementary therapies. IPT targets the delivery of specific drugs to the cancer cells, bypassing most …

View the entire article on our website, click here >> http://goo.gl/4u72p .

Pancreatic Cancer | Cancer of the Pancreas:Cancer21-AdamSketch

It is important to know what they may be sensitive to, and so immediately we test for chemosensitivity – which drugs will work best for you. If we are seeing you …

View the entire Pancreatic Cancer article on our website, click here >> http://goo.gl/NgMUr .

Cancer | Cancer Prevention:

Cancer | Cancer Prevention.Cancer21-Chart

The BioFocus Analysis is also a chemosensitivity test. Like all cells, tumor cells have a genetic makeup. Knowing that makeup tells us which treatments are …

View the entire Cancer and Cancer Prevention article on our website, click here >> http://goo.gl/CTxi1 .

Bioenergetic Modalities:

The Chiren.Cancer21-Chiren

Dr. Martha M. Grout of the Arizona Center for Advanced Medicine and Clinical Research in Scottsdale, Arizona, practices homeopathic medicine which

View the entire article on the Chiren, click here >> http://goo.gl/AKjep .

The Chiren™ – Delving Deep into the Nature of Life Itself · Erectile Dysfunction · Fish Oils and Oils, Fats and Trans Fats · A Public Relations Campaign on Oils

View the entire article on the Chiren, click here >> http://goo.gl/AKjep.

Energy Medicine | Bioenergetic Medicine:

Energy Medicine | Bioenergetic MedicineCancer21-Suppliments

Energy medicine works with our natural energy field to stimulate the body’s own healing mechanisms.

View the entire Energy medicine article on our website, click here >> http://goo.gl/Itu0w .

Body Burden and Chronic Disease and DetoxCancer21-YouTube

We reverse chronic illness with detoxification through chelation, colonics, nutrition, and bioenergetics to decrease the body burden of heavy metals. Dr. Martha

View the entire Body Burden and Chronic Disease and Detox article, click here >> http://goo.gl/Rj9YI .

View a complete library of article on the Arizona Center for Advanced Medicine website, click here >> http://goo.gl/8kEPI .

Sources:

[1] http://seer.cancer.gov/statfacts/html/tongue.html downloaded 11-19-12

[2] http://www.oralcancerfoundation.org/dental/screening.htm downloaded 11-19-12

[3] http://oralcancerfoundation.org/ downloaded 11-19-12

[4] http://www.cancer.gov/cancertopics/pdq/screening/oral/Patient/page3 downloaded 11-19-12

[5] http://oralcancerfoundation.org/ downloaded 11-19-12

[6] Epstein JB, Silverman S Jr, Epstein JD, et al. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol. 2008;44(6):615. http://www.ncbi.nlm.nih.gov/pubmed?term=17996486

[7] http://www.zila.com/40/VIZILITE%26REG%3B%20PLUS/ downloaded 11-19-12

[8] http://www.zila.com/40/VIZILITE%26REG%3B%20PLUS/ downloaded 11-19-12

[9] St JohnMA, Li Y, Wong DT et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug;130(8):929-35.

[10] Korostoff A, Reder L, Masood R, Sinha UK. The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 2011 Apr;47(4):282-7.

[11] http://www.advanced-lab.com/news/Newsletter_July2012.pdf downloaded 11-19-12

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Bladder Cancer – What caused it? Cancer Series #20. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer20

Cancer Series # 20 – Bladder Cancer – What caused it? Why me? Why now?

Bladder cancer is the fourth most common cause of cancer in men. There are well established guidelines for its treatment.[1] Nevertheless, the 5-year relative survival statistics are not good, once the cancer has spread beyond the superficial layers of the bladder.[2]LogoAmerCancerSoc

The American Cancer Society has an excellent web article about bladder cancer, describing the conventional medical understanding of its treatment.[3]

Causes of bladder cancer are multiple. As with any cancer, there is a predisposition for problems in that organ system (kidney/bladder). The cancer20-diagramkidneys are a major organ of excretion of many chemicals which are stored in the bladder while waiting to be expelled from the body through urination.

On top of the predisposition, there is an inciting factor (or several) which may include chronic infections, arsenic in drinking water, prior chemotherapy or radiation therapy, birth defects, deficiencies of detoxification enzymes (GST – glutathione-S-transferase – or NAT – n-acetyl transferase).

The industries carrying highest risks include the makers of rubber, leather, textiles, and paint products as well as printing companies. Other workers with an increased risk of developing bladder cancer include painters, machinists, printers, hairdressers (likely because of heavy exposure to hair dyes), and truck drivers (likely because of exposure to diesel fumes). Cigarette smoking and workplace exposures may act together to cause bladder cancer. Smokers who work with the cancer-causing chemicals noted above have an especially high risk of developing bladder cancer.[4]

Smokers are twice as likely to develop bladder cancer as non-smokers.cancer20-smoking

What we fail to recognize, in our allopathic Western medicine, is that cancer is the body’s ultimate cry for help in a situation of unresolved conflict.[5] The conflict may be purely physical – i.e. exposure to toxic chemicals. More often the physical is superimposed upon a psychological conflict – some kind of emotional shock and conflict – which generally occurs one to two years before the tumor manifests. This is not to say that the emotional shock is the cause of the tumor, but rather that the shock opens the door so that the tumor can progress.

At the Arizona Center for Advanced Medicine we use multiple modalities in the treatment of cancer.

When surgery and/or radiation therapy are indicated, we recommend it, and help our patients find the appropriate surgeon and/or radiation oncologist to perform the procedure.

We treat the cancer using Insulin Potentiation Therapy (IPT) – which allows us to use standard chemotherapeutic drugs at a MUCH lower dose than standard chemotherapy – so that we get the benefits of chemotherapy without most of the side effects.

View one of our patients having I.P.T. treatment below…

We test the chemotherapeutic agents to see which ones have the greatest kill rate for the individual patient’s circulating tumor cells (and original tumor cells, if a fresh specimen is available). Thus, we can use chemotherapy which actually works on the individual tumor, rather than chemo that has been tested in hundreds of patients and works on 30 or 50 or 75 percent of their tumors. We use combinations of drugs based on testing, whether they are standard combinations or not.

We re-test periodically, to make sure that we are still administering the appropriate agents, because cancer cells are infamous for Cancer20-killcellsmutating, changing their characteristics from generation to generation as the cells rapidly divide. Their DNA is notoriously not stable, so daughter cells may have very different characteristics from the parent cancer cell – which is already very different from the normal cells.

We also treat with supplements and botanicals which are known to have an effect on cancer cells and on the immune system. Medicines like artemisinin, mistletoe, genistein, naltrexone (in very low dose), modified citrus pectin and many others are known to stimulate cancer cell apoptosis (cellular suicide), decrease the formation of new blood vessels, stimulate our own natural killer cells, and decrease the likelihood of cancer cells metastasizing and setting up shop for new tumor formation.

We help our patients investigate the potential emotional shocks which may have been the trigger for the development of the cancer which brought them to us. We do not force the issue, but we do hold the light on the path.

And our success rate is measured in quality of life and resolution of conflict. The sooner we are able to treat, the better. Some have no recurrence of cancer. Others experience arrest of tumor growth. And some experience progression of the tumor. There are no guarantees of healing – any more than there are in conventional oncology. The only guarantee is that the treatment is much more gentle, does not often cause major side effects, and is administered in an atmosphere of caring – both from the staff at the Center and from the other patients.

Conventional oncology is beginning to realize that there is a connection between cancer treatment and the state of metabolism. A few researchers are looking in to the relationship between glucose uptake and cancer cell growth and chemotherapy treatment.[1],[2],[3] And the drug companies are starting to take an interest in the concept.[4]

Physiologically, all cancers are caused by an alteration in the metabolism of the cells which turn cancerous. Otto Warburg was awarded the Cancer20-DrWarbergNobel Prize for this discovery. The big question is: what causes the cells to so drastically change their metabolism? Is it environmental pollution? Is it infection by viruses, bacteria or fungi? Is it terrible eating habits? Is it emotional distress? Is it traumatic experiences?

In the end, all cancers are caused by interaction between the internal and the external environment – our genetic predispositions, our life history, and the external factors to which we are exposed. All these factors must be addressed and resolved, for true healing to occur.

We at the Arizona Center for Advanced Medicine are honored to share in the journey of our patients, and are always searching out new and innovative therapies, keeping our patients’ best interests at heart.

Hear from one of Arizona Center for Advanced Medicine cancer patients …

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Additional information on possible causes of bladder cancer…
Here are additional comments on bladder cancer by Dr Martha Grout M.D.(H), Arizona Center for Advanced Medicine, Scottsdale, AZ. Much has been written about the association between organ dysfunction and emotional shock, by Dr.  Ryke Geerd Hamer[1], Carolyn Myss[2], DrGroutWChristine Page and others. But the concept did not originate in the 21st century. Chinese Medicine, since its earliest recorded texts, has associated the organs with specific emotional characteristics – the Heart with mania, the Spleen with worry, the Lung with grief, the Bladder with fear, the Liver with anger.

So is bladder cancer related to not being able to “mark our territory”? Loss of power or position at work or in relationship? Fear may be a big factor in the development of bladder cancer. One of the first things that happens when we are faced with a situation of acute fear for our lives is that our bladder let’s go and we wet ourselves. It is a natural fight-or-flight response – when lions are chasing us, we do not need to be held back by the extra weight of urine. The contraction of the bladder is a reflex part of that fight-or-flight reaction. When we are chronically afraid for our lives – never sure of our security or position on the job or at home – we may well develop bladder symptoms, and even cancer, if the situation goes on long enough and other conditions are right.

 View video below “Chronic vs acute illness: Ask Dr. Martha Grout”…

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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LogoYogaJournal

Why People Don’t Heal

Myss’s core teachings revolve around releasing victim consciousness and embracing forgiveness. Observing a friend reveal, in an inappropriate context, that she was an incest survivor, Myss realized that we “show our wounds” as a way to get close to each other. “Woundology,” as she calls it, “is our first language of intimacy.” The problem with bonding this way, Myss says, is that it gives power to victim consciousness and keeps people wounded.

Recently Myss has had to work on rebuilding her own health. In 1992, two weeks after she began to wonder why people don’t heal, Myss became ill with a condition that worsened until she found herself, three years later, in a “place of incredible desperation,” saying, “I want out-I can’t deal with the pain.” She searched for guidance from, of all things, her tape “Why People Don’t Heal,” taking notes on the part about forgiveness. Realizing she needed to forgive two people in her life, she asked the gods to arrange opportunities for contact with these people. Within a few months, both conflicts came to resolution. Now, she says, “The things I’m doing to engage my health are going to start working. Because I’m playing by these rules.” “I know the gods hold me accountable to walk the way I talk,” she says. “A teacher is dishonorable who doesn’t do that.”

View the entire article with an excellent interview with medical intuitive Carolyn Myss, click here >> http://goo.gl/P4Gar.

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logoResearchGeneticCenterGermany

Research Genetic Cancer Center, GmbH, is a laboratory in Greece to which we send peripheral blood samples, specifically for the genetic analysis of circulating tumor stem cells, both for cell count and for chemo-sensitivity. The lab also measures sensitivity to botanical and other medicinal treatments used in cancer therapy. This test is not covered by insurance. The biggest difference between this laboratory and others in the United   States is the chemosensitivity testing.

Genetic testing of tumor cells is available in the United States, but so far the available tests do not appear to have the advantages of those available to us through the RGCC lab.

The CellSearch ® Circulating Tumor Cell (CTC) Test from Veridex is a blood test that assesses circulating tumor cells to give an estimate of survival of patients with metastatic breast, colorectal or prostate cancer at any time. It does not measure chemosensitivity, nor is it covered by insurance.

The Rational Therapeutics laboratory tests fresh tumor samples for chemosensitivity. This test requires tumor tissue from surgery or biopsy. It does not test circulating tumor stem cells. It is not covered by insurance.

Caris Target Now® molecular profiling identifies specific genetic mutations associated with benefit (or lack of benefit) from particular families of chemotherapeutic agents. It is a test of probability, not of chemosensitivity, and requires a tissue specimen. It is occasionally covered by insurance.

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Sources:

[1] http://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf

[2] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-survival-rates

[3] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-what-is-cancer

[4] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-risk-factors

[5] http://www.health-science-spirit.com/hamer.html

[6] Jiao SC, Huang J, Sun Y, Lu SX. The effect of insulin on chemotherapeutic drug sensitivity   in human esophageal and lung cancer cells. Zhonghua Yi Xue Za Zhi. 2003 Feb 10;83(3):195-7.

[7] Porter HA, Carey GB, Keegan AD. Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Exp Cell Res. 2012 Aug 15;318(14):1745-58. Epub 2012 May 28.

[8] Graham NA, Tahmasian M et al. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26;8:589. doi: 10.1038/msb.2012.20.

[9] http://www.cornerstonepharma.com/cancer-metabolism/overview

[10] http://learninggnm.com/documents/hamerbio.html

[11] http://www.natural-connection.com/resource/yoga_journal/why_people_dont_heal.html

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Do you know the cost of Cancer Care? Cancer Series #19. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer19

Cancer Series #19 – Cost of Cancer Care.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

A recent news brief from the American Society of Clinical Oncology[1] was about the skyrocketing costs of cancer care. The author was discussingCancer19-ASCOlogo the cost of cancer care for people with sickness insurance, mind you. Dr. Thomas J Smith is quoted as saying: “The costs of cancer care are rising at an unsustainable rate, and the quality and value of the care is often suboptimal … Insurance premiums have doubled over the past decade, as have out-of-pocket patient costs. These unsustainable costs have resulted in 1 million health-related bankruptcies in the United States this year alone.”

Why in the world do we have so-called “health” insurance, if we still go bankrupt when we become ill?

An article published in Newsweek in August 2012[2] says: “According to figures from insurer United Healthcare, a standard cocktail of drugs for treating lung cancer used to run about $1,000 a month. Today’s regimens cost from more than $6,000 to almost $10,000—for about two more months of life.” The same article talks about the minimal extension of life – as little as two months longer median survival is considered to be a Cancer19-patientIPT“success”, a great “break-through”.  There is no mention of the quality of life, whether it is good, or whether it’s just miserable life full of side effects from the additional chemo treatments.

Patients who decide on treatment using integrative modalities and insulin potentiated chemotherapy (IPT) end up paying about as much as they would pay if they did conventional treatment, because of the deductibles, drugs not covered by their insurance, tests not covered by their insurance, etc. Their outcomes are no worse – and sometimes significantly better. Their quality of life is always significantly better.

View more information on and insulin potentiated chemotherapy (IPT), click here >> http://goo.gl/PvpCu .

Average cost of an IPT regimen (including the integrative aspects of the regimen outlined in the next paragraph) is approximately $50-60,000.00. The cost may be greater or less, depending on the cost of the chemotherapeutic agents (some are very expensive even in the small doses that we use for IPT) and whether “health” insurance covers the cost of some of the X-rays, surgical procedures (e.g. chest port insertion, cancer19-Immunedrainage of fluid from the lungs or the abdomen) and routine lab work.

In addition to IPT chemotherapy, we also do many other treatments to help to support the immune system, clean up the diet and the intestinal tract, using supplements and botanical medicines to fill in nutritional potholes and restore good metabolic function. We help our patients to locate and clear out any unfinished business they may have, on all levels, physical, emotional, mental and spiritual, in order to remove any potential blocks to healing. We provide our patients with a sense of community, and interaction with others who are also facing health challenges.

Cancer19-hands

The cost of such comprehensive care is what it is. The value of such care is priceless.

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g.

View more information on the important subjects above…

View more information on the immune system, click here >> http://goo.gl/ztoHS .

View more information on the diet and the intestinal tract, click here >> http://goo.gl/MCHFT .

View more information on removing potential blocks to healing, click here >> http://goo.gl/egXtR .

View the video below on the I.P.T. process…

Sources:

[1] Piana R. Despite the Rhetoric, Cancer Care Costs Keep Skyrocketing: Is There a Solution? ASCO Post November 1, 2012, Volume 3, Issue 16

[2] The Cancer “Breakthroughs” that Cost Too Much and Do Too Little. Aug 27, 2012 1:00 AM EDT

LogoASCOpost

Despite the Rhetoric, Cancer Care Costs Keep Skyrocketing: Is There a Solution?

The consequences of changing our practice habits will result in equal or better care and sustainable growth in our delivery system. Thomas J. Smith, MD, FACP

Although health-care experts routinely agree that the rising costs of oncology services are untenable, there is disagreement about how to reduce expenditures without harming access and quality of care. At this year’s ASCO Annual Meeting, Thomas J. Smith, MD, FACP, offered some interesting ideas about how to bend the cancer care curve downward.1

Recognizing the Problem

According to Dr. Smith, to maintain our ability to deliver high-quality cancer care, the oncology community must begin bending the cost curve downward, and the first step is an honest recognition of the problem. “The costs of cancer care are rising at an unsustainable rate, and the quality and value of the care is often suboptimal,” said Dr. Smith.

Dr. Smith made the case that health care is often less than optimal with data from studies that looked at care patterns for patients with cancer. The findings he presented—such as inadequate use of hospice benefits, a lack of doctor-patient conversations about advance directives, and overuse of chemotherapy in the final weeks of life—are well documented in the literature, as is the disproportionate health-care spending in the United States compared with other Organisation for Economic Coordination and Development (OECD) nations. “We spend about $8,000 per person per year, nearly double the expenditures in Canada, which spends about $4,500 per person with equivalent or better national health-care outcomes than the United States,” said Dr. Smith.

Dr. Smith stated the hard facts: “Our yearly health-care budget is approaching $3 trillion, which is devouring our [gross domestic product]. Insurance premiums have doubled over the past decade, as have out-of-pocket patient costs. These unsustainable costs have resulted in 1 million health-related bankruptcies in the United   States this year alone.”

Value Needs to Reflect Price

Balancing value vs the cost of drugs and services is rapidly becoming a central theme in the health-care narrative. Dr. Smith gave several examples in which cost has outstripped value. “Some of the workhorse oncology drugs that have real clinical value are priced relatively inexpensively. For instance, paclitaxel and trastuzumab [Herceptin] cost less than $5,000 per month; however, some of the newer drugs such as pemetrexed [Alimta] cost about twice that at $10,000 per month. And, in the extreme cases we have drugs such as sipuleucel T [Provenge], which cost almost $100,000 for one administration,” noted Dr. Smith, adding that data show that many of the newer drugs do not add enough clinical value to warrant the sticker-shock costs.

Dr. Smith stressed that most of the spending increases are well within our control. “Based on geographic variations, the congressional budget office (CBO) estimated that upward of 30% of clinical care is not evidence-based and does not add value for the patient. Things that oncologists do have control over are the use of imaging, chemotherapy selection, supportive care services, surveillance after curative care, proper and timely use of palliative care and hospice, and avoiding unnecessary therapy and hospitalization near the end of life,” said Dr. Smith.

Behavior Modification

As Dr. Smith pointed out, part of the rise in oncology costs is driven by physicians’ practice behavior, with respect to the underuse of cost-saving interventions such as palliative care and hospice, and overuse of unwarranted services and therapies. Palliative care and hospice actually improve the quality of care, at an affordable cost. And some of the most expensive treatments are no better than things they replace; for instance, MemorialSloan-KetteringCancerCenter just elected to not cover ziv-aflibercept (Zaltrap), which costs twice as much as the comparison drug. In an effort to curb unnecessary spending, ASCO has joined the American Board of Internal Medicine in the “Choosing Wisely” campaign, which encourages medical groups to select five areas in which they can improve care and reduce costs.

Dr. Smith highlighted the ground rules for the campaign. “Everything is on the table for discussion. We need to accept data where it exists, curative and adjuvant care along with clinical trials are always exempt, and perhaps most importantly, we need to recognize that this is going to be painful,” he said.

“For instance, “ he continued, “supportive care and chemotherapy administration represent a main source of an oncologist’s income, so modifying certain practice methods to save money will ultimately reduce practice revenue—painful but necessary. Also, patients with cancer are a hefty source of hospital income; reducing hospital days will affect the institution’s bottom line.”

Another bridge to cross is the initiation of comprehensive discussions about death and medical costs, subjects that both doctors and patients traditionally shy away from. “These discussions have been shown to save money and add to a patient’s quality of life,” said Dr. Smith.

Targeting Overvalued Treatment

“The first area we targeted was aligning surveillance procedures to patients who were most likely to derive benefit. For instance, in 1990 we spent at least $1 billion in breast cancer screening [for recurrence]. Today that number is several billion dollars. However, the ASCO and National Comprehensive Cancer Network (NCCN) guidelines agree that in the absence of symptoms, there is no evidence that CEA, CA 27-29, positron-emission tomography, computed tomography, and bone scans have any value as screening tools to follow women,” said Dr. Smith.

He emphasized that screening guidelines can be reviewed in less than 10 minutes, giving doctors the opportunity to explain to their patients that these expensive screening methods have no guideline-proven benefits for their breast health. “Instead, we should stress breast care that is effective, such as timely mammograms and maintaining a healthy lifestyle. The solutions that we proposed are that payers simply should not reimburse for these tests and the ASCO Quality Oncology Practice Initiative (QOPI) committee should audit for overuse,” said Dr. Smith.

Another recommendation was to only use sequential or monotherapies in the second-line setting or later metastatic treatments. Dr. Smith explained why this approach was important. “Patients will live just as long, and they will avoid unnecessary toxicity. This will result in fewer supportive care costs, fewer hospitalizations, and will ultimately lower oncology costs. Naturally, this approach requires honest discussions about goals of care.”

Dr. Smith remarked that it is also important to limit active therapy to patients with good performance status. “A good screening question to ask is, ‘Did this patient walk unaided to the clinic?’ If a patient’s ECOG performance status is 3 or 4, a discussion of prognosis and realistic treatment expectations should ensue,” noted Dr. Smith, adding that he and his colleague Bruce E. Hillner, MD, have written extensively about dose reductions that can obviate the need for granulocyte colony-stimulating factors (G-CSF) in solid tumors.

“The United States has 3% of the world’s population, but buys 75% of the world’s G-CSF. These drugs are essential when using certain types of chemotherapy, but we have not found any trial that shows better survival rates when using G-CSF in solid tumors,” said Dr. Smith.

One other “Choosing Wisely” recommendation was to switch to nonchemotherapy palliative care after the cancer grows through two or three regimens. “Using NSCLC as an example, we see that the use of chemotherapy after two or three regimens is toxic, expensive, rarely helpful, and prevents the planning for transitions to end-of-life care, such as timely entry into hospice,” said Dr. Smith.

Conclusions

Along with ASCO’s “Choosing Wisely” recommendations, Dr. Smith stressed that we need to change payment methods from those that incentivize overuse of testing and treatment to mechanisms that reward best practices.

“Under the current fee-for-service practice, oncologists derive more than 50% of their revenue from the drugs they prescribe. I think this system will face continued pressure to change,” said Dr. Smith. “One alternative is fixed provider payment systems (ie, salaried physicians), in which physicians will trade lower revenue streams for more secure incomes. It’s important to note that the Veterans Affairs systems have equivalent outcomes to private practices while working on a fixed budget. Moreover, as a community, we eventually need to see Medicare as a scarce resource, not a profit center.”

Dr. Smith said that the oncology community could provide actionable solutions to improve both quality and cost of care by using treatments based on evidence, better end-of-life care and coordination, more standardized practice methods, using clinical pathways, and more auditing with the intent of practice change. “The consequences of changing our practice habits will result in equal or better care and sustainable growth in our delivery system,” concluded Dr. Smith.

View the entire article, click here >> http://goo.gl/IyoPj .

logoDailyBeast

Price Of Newer Cancer Drugs May Not Be Linked To Benefits.

The Daily Beast (8/27, Beil) reports, “Treating cancer has never been cheap, but today, the price of each new treatment seems to outpace the one before, with little bearing on its efficacy.” About eight years ago, “researchers tried to test the relationship between a drug’s development and its final asking price.” But, “in the Journal of Clinical Oncology, the scientists concluded ‘that the drug companies are not pricing their drugs to recuperate losses associated with research and development, marketing, and operating prices, but rather [the average wholesale price] depends on what the market itself can bear.”

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The Cancer “Breakthroughs” that Cost Too Much and Do Too Little

‘Death panels’ are a bad idea. But asking hard questions about health care is not.

In his more than 35 years of practice, Dr. Lowell Schnipper has seen a lot of women die from breast cancer. A patient’s options start to dwindle by the time tumor cells set up outposts in the bones, lungs, and other organs, defying all attempts to keep them under control. But in June, when the government approved Perjeta, Schnipper had something new to offer. The drug is one of an innovative class of drugs known as “targeted therapies.”

As the chief of oncology at Beth Israel Deaconess Medical Center in Boston, Schnipper knew Perjeta was not a cure: combined with Herceptin—another targeted therapy that was hailed as a breakthrough in 1998—Perjeta gives the average woman only about six months of calm before her disease starts to stir again. Given the limited benefit, the price was startling. For most women, a full course of the drug combination will cost $188,000—enough, he says, “to give anybody a cold sweat.”

Americans spent more than $23 billion last year for cancer drugs, more than we paid for prescriptions to treat anything else. But many oncologists are starting to question what we are getting in return for that bill, whether the war on cancer has become too much of a race to produce the next blockbuster. “In general, progress for cancer has been halting and slow,” says David Howard of the Department of Health Policy and Management at EmoryUniversity. So far, most new drugs offer only marginal extensions of life and few cures. Howard says new so-called breakthroughs “overpromise and underdeliver.” Consider the popularity of Avastin, a targeted drug approved for metastatic colon cancer in 2004. A recent study found that almost 70 percent of patients on chemotherapy were receiving Avastin within a year of its release. In clinical trials, the drug increased survival by about five months. The cost? About $10,000 a month.

Treating cancer has never been cheap, but today, the price of each new treatment seems to outpace the one before, with little bearing on its efficacy. According to figures from insurer United Healthcare, a standard cocktail of drugs for treating lung cancer used to run about $1,000 a month. Today’s regimens cost from more than $6,000 to almost $10,000—for about two more months of life. “There is no such thing as a cancer drug coming on the market that is some sort of regular drug price,” says Dr. Peter Bach of MemorialSloan-KetteringCancerCenter in New York, who studies the impact of cancer costs on U.S. health care. “They’re all priced at spectacularly high levels.” Which leads to an unsettling question: how much is a little more time worth? Would you spend $50,000 for four more months? How about $15,000 for two weeks?

Of three frontiers in cancer treatment, targeted therapies like Perjeta are widely seen as the best hope for a cure. Traditional chemotherapy is notorious for side effects because it wields destruction indiscriminately throughout the body. Targeted therapies are designed to hit cancer cells only. Perjeta, for example, targets a protein produced in excess amounts in some breast cancers; Avastin hinders the ability of a tumor to form new blood vessels to feed itself.

Doctors envision the day when every patient will have therapy precisely matched to the genetic bull’s-eyes of their own cancers. The holdup has been that cancer has proven to be more genetically crafty than researchers once imagined. Scientists may build a drug to hit one target, but a tumor may also employ lots of yet-undiscovered genetic tricks to keep itself alive. Instead of a magic bullet, scientists now know that any particular tumor may need lots of magic bullets. With so many targets unknown, a lot of patients end up getting drugs that barely touch their cancers, which is why the effectiveness of many new drugs remains underwhelming.

Not that this keeps a drug from becoming a blockbuster. Patients with advanced cancer, and their physicians, are hungry for progress. As a result, almost all of the 10 bestselling cancer drugs are targeted therapies, many less than a decade old. All came on the market at thousands of dollars a month, a trend that continues today with gusto. The drug Afinitor, a daily pill, was approved in July for patients with breast cancer. It costs more than $200 a tablet. But price rarely matters to patients or even doctors, says Dr. Oliver Sartor, medical director of the TulaneCancerCenter in New Orleans. “People have already been told there is no cure for their disease,” he says. “Every increment, every improvement, gives hope, and when options are extremely limited, we all focus on the positive possibilities.”

View the entire article, click here >> http://goo.gl/IccDF .

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Integrative Cancer Care. Cancer Series #18. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer18

The Exclusive Cancer Series #18 – Integrative Cancer Care.

Important information cancer patients and their families should know.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Chemo, surgery, radiation – this is the mantra of current recommendations for cancer therapy. Treatment options on the website of the Mayo Cancer18-BestAnswerLogoClinic, “the most innovative, progressive care anywhere” are the following: bone marrow transplantation, chemotherapy, radiation therapy and radio frequency ablation.[1]

And yet… the incidence of cancer is projected to rise 75% by the year 2030.[2] What is wrong with this picture?

Insulin potentiation chemotherapy, low dose

The National Cancer Institute describes side effects of conventional chemotherapy on its website.[3]Cancer18-vomit

Some common side effects from chemotherapy are fatigue, nausea, vomiting, decreased blood cell counts, hair loss, mouth sores, and pain… Sometimes, chemotherapy causes long-term side effects that do not go away. These may include damage to your heart, lungs, nerves, kidneys, or reproductive organs. Some types of chemotherapy may cause a second cancer years later.

The website does not mention death from destruction of the immune system and systemic infection.

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View an entire article on Insulin potentiation chemotherapy at our website, click here >> http://goo.gl/gaXOZ .

Chemotherapy is actually pretty effective for a few cancers.4 Greater than 10% survival can be attributed to cytotoxic chemotherapy in the following cancers: cervix 12%, ovary 8.7%, testicle 41.8%, Non-Hodgkins Lymphoma 10.8%, Hodgkins Lymphoma 35.8%. Breast cancer gets only 1.5% survival increase from chemotherapy, colon cancer 1.8%, brain cancer 4.9%.

Why are we so quick to put conventional chemotherapy first on the list for cancer treatment? Graeme Morgan, an Australian radiation oncologist, writes: “For most patients, the use of cytotoxic chemotherapy is for the palliation of symptoms and to improve quality of life.” However, Dr. Morgan concludes: ““The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.” [1]

If conventional chemotherapy were less toxic, it might be worth it. But for a 2.5% benefit? It is hard to discern the advantages.

Most people are not aware that there is a gentler form of chemotherapy, known as Insulin Potentiation Therapy, low dose.[2],[3] This therapy is just as effective as standard chemo, without all the painful and sometimes lethal side effects. Insulin is used to lower the blood sugar, resulting in relatively increased starvation of cancer cells which require more sugar than normal body cells. Once the blood sugar is sufficiently low, sugar is given intravenously, along with a small dose of chemo (about 10-15% the usual dose). The chemo is sucked into the cells, along with the sugar, and concentrates in cancer cells because they are so much more avid for sugar than normal cells.[4],[5]

With IPT, the incidence of so-called side effects is markedly decreased. Most of our patients drive themselves home from treatment. They may report a little fatigue on the day of treatment. Seldom do they lose any hair at all, and they hardly ever drop their white blood cell counts. They are able to lead normal lives during the course of their IPT therapy.

View the FREE video below describing I.P.T. therapy at Arizona Center for Advanced Medicine…

If our therapies are so effective, why is the incidence of cancer projected to rise so dramatically? And why are the therapies in fact not effective Cancer18-Fig1for every form of cancer?

Our bodies are full of toxins – chemicals from our foods and from the air we breathe, artificial colorings and flavorings, artificial sweeteners (like chlorinated hydrocarbons, or pesticides), high levels of sugar with consequent high levels of insulin, or even frank diabetes. So it is not surprising that mutations can occur. That is the essence of cancer. The cells mutate to a lower state of being, one where they are only concerned with growth, and not with the good of the entire organism.

Insulin Potentiation Therapy – even low dose – is NOT ENOUGH to treat cancer, any more than chemotherapy by itself is a sufficient treatment. For truly integrative cancer therapy, many different modalities are brought into play.

It is helpful to know which chemotherapy to use – which actually kills your cancer cells, not just which has been studied and had a good effect on 30% or 50% of people in whom it was tried. It is equally helpful to know which complementary – botanical and supplemental – therapies could be therapeutic.

Chemosensitivity testing is available – but not in these United States, unfortunately.  We use a laboratory in Greece, run by an oncologist, to determine which drugs and which supplements to use for the greatest effect. 

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View more information on the Greek RESEARCH GENETIC CANCER CENTRE LTD methods, click here >> cancer18-Fig2http://goo.gl/hEh1F , and scroll about half way down the page.

  • We use standard chemotherapeutic agents – and sometimes even standard combinations as recommended in the current oncology literature.[1]
  • We use botanical remedies like Iscador[2], and supplements like high dose Vitamin C[3] (but not if bortezomib is part of the regimen chosen[4], lipoic acid[5], glutathione[6] and many others, to restore the function of natural killer cells, and to bring the body back to a state where it can defend itself against the foreign cancer cell invaders.
  • We teach our patients the basics of a healthy diet – encouraging mainly plant-based foods[7] in  the early phases.
  • We test for nutrient deficiencies, and administer nutrient IV therapies to replenish the body’s stores.Cancer18-Fig3
  • We work with our patients to help them dismantle barriers to healing – old dogma, old conflicts, old beliefs, old injuries, physical or emotional, which they have been unable to see or unwilling to give up.

View more information on the Arizona Center for Advanced Medicine website…

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View more information on basics of a healthy diet, click here >> http://goo.gl/HrAjT .

View more information on nutrient IV therapies, click here >> http://goo.gl/2usMN .

View more information to dismantle barriers to healing, old beliefs, click here >> http://goo.gl/nUdhX .

Cancer18-beliefLEFT

As with any medical therapy, it is unwise to throw out everything, because each form of therapy has its use. Chemotherapy does indeed kill many cancer cells. High dose Vitamin C kills many others. Anti-inflammatory supplements and spices help to restore balance to the immune system. Cancer18-textgraphicNutrients help to sustain the body in its battle. And release of old stuff helps to restore the soul to a place of gratitude and love.

Every modality plays a part in our therapies. We are honored to share the journey with our patients. We would prefer to share the journey earlier in its course rather than later, when the immune system is already gone, and the body is in desperate straits.

Standard chemotherapy is like a bomb exploding, creating collateral damage to the organism.

Insulin Potentiation Therapy, when combined with Integrative and Functional Medicine Therapy, is a lifeline to help restore physical function and enable the body to heal.

Hear from an actual Cancer patient in the video below…

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For more information about our integrative cancer care, please visit the website, click here >> http://goo.gl/oMoAu.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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Sources:

[1] Downloaded 12/2/2012 from http://www.mayoclinic.org/cancer-treatment/diseases.html

[2] Bray F, Jemal A, Forman D et al. Global cancer transitions according to the Human Development Index (2008—2030): a population-based study. The Lancet Oncology, Volume 13, Issue 8, Pages 790 – 801, August 2012

[3] Downloaded 12/2/2012 from http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you/page5

[4] Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.

[5] http://www.arizonaadvancedmedicine.com/therapies/IPT_therapy.html

[6] http://www.bestanswerforcancer.org/what-is-insulin-potentiation-therapy-low-dose-iptld/

[7] Raffaghello L, Safdie F, Longo VD et al. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15;9(22):4474-6.

[8] Lee DH, Raffaghello L, Longo VD et al. Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Sci Transl Med 7 March 2012: Vol. 4, Issue 124, p. 124 – 27

[9] Chu E, DeVita VT. Physicians’ Cancer Chemotherapy Drug Manual (updated every year). © Jones & Bartlett Learning, LLC. ISBN 978-1-4496-4683-7.

[10] Strüh CM, Jäger S, Martin SF et al. A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells. Phytother Res. 2012 Feb 8. doi: 10.1002/ptr.4604.

[11] Frei B, Lawson S. Vitamin C and Cancer Revisited. PNAS August 12, 2008 vol. 105 no. 32

[12] Perrone G, Hideshima T, Anderson KC et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia. 2009 Sep;23(9):1679-86.

[13] Zachar Z, Marecek J, Bingham PM et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

[14] Singh S, KhanAR, GuptaAK. Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol. 2012;9(4):303-16.

[15] Campbell TC, Campbell II TM. The China Study. © 2006, BenBella Books. ISBN 978-1932100-66-2

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Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Find, Follow, LIKE and See us everywhere at ‘AdvancedCancerAZ’.


Inflammation and Cancer – is there a link? Cancer Series # 17. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical treatment for cancer in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer17

Cancer Series #17 – Inflammation and Cancer – is there a link?

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

An excellent definition of oxidative comes out of a review paper published in 2010 on the National Institutes of Health (NIH) website:

Oxidative stress is defined as an imbalance between production of free radicals and reactive metabolites, so-called oxidants or reactive oxygen species (ROS), and their elimination by protective mechanisms, referred to as antioxidants. [1]

Electron transfer to oxygen occurs at the level of the electron transport chain in the cell membranes of the mitochondria – the little structures within the cell which produce our energy and help us dispose of our cellular waste (free electrons) as long as we provide them with the appropriate trash cans to dispose of the wastes. These trash cans are called anti-oxidants.

Under conditions of sustained stress, and depletion of anti-oxidants, the mitochondrial electron transport chain becomes overwhelmed.

Some level of ROS is a perfectly normal state of affairs within the cell, producing molecules which let the body know that trash-collection is Cancer17membraneneeded, ROS being the normal end-product of cellular metabolism. “… aerobic cells produce ROS such as superoxide anion (O2-), hydrogen peroxide (H2O2), hydroxyl radical (OH•), and organic peroxides as normal products of the biological reduction of molecular oxygen”.[2]

A little ROS stimulates the call for anti-inflammatory molecules. A lot of ROS is, on the other hand, quite damaging to the body. Excessive ROS stimulates growth factors, cell cycle regulators, and more damaging types of ROS which can in fact alter or destroy mitochondrial DNA, and eventually the DNA of the cell itself.

Initiation of cancer has been linked to this form of DNA damage.[3] Protection against such damage is provided by several enzymes – superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, catalase – as well as anti-oxidant substances like glutathione (GSH), Vitamin C, and Vitamin D.

Rudolf Virchow first noted in 1863, that inflammatory cells are present within tumors, and that tumors appear to arise at the site of chronic inflammation.[4] The link between ulcerative colitis and colon cancer is well established, with “cumulative probabilities of [development of colon cancer of] 2% by 10 years, 8% by 20 years, and 18% by 30 years”.[1]

Tumor-associated macrophages are a major component of almost all tumors.[2] Macrophages are essential cells for wound healing, and tumors Cancer17-cellshave been described as “wounds that never heal”.  Tumors appear to co-opt the wound healing process, and turn it into a wound-perpetuating process – as has been demonstrated in the zebrafish embryo. [3]

Now, finally, it begins to make sense that emotional wounds can also be linked with cancer development. If we believe in the concept of “as above, so below”, if we truly understand that our minds, our emotions and our bodies are not separate entities, but one living organism, then finally we begin to connect the dots between the intolerable situation we experienced as a child, and which we never expressed or discharged, and the colon cancer which developed in the organ the body uses to discharge its wastes.

A review of PubMed using the search terms “emotional wound”, “forgiveness”, and “cancer“ brought up no articles relevant to the emotional LogoPubMedaspect of the wound, but plenty of articles about the emotional aspects of dealing with a diagnosis of cancer. Using the search terms “forgiveness” and “stress” brought up 60 articles, but only one article related to cancer[4] – and that article talked about self-forgiveness after the diagnosis was already made.

A Google search using the same terms brought up over 2 million hits. Fox News has a segment with Dr. Michael Barry, who discusses the relationship between the immune system and stress, which he relates to lack of forgiveness.[5]  He likens it to trying to drive a car with the parking brake on – dragging around a lot of excess baggage. He is careful to note that there is no research on the subject – but at least he discusses the concept.

So, if we can buy the concept that psychological stress causes inflammation on the physical level, then it’s not too far a leap to the place where finding something “impossible to swallow” results eventually in cancer of the throat or the esophagus, where being “suffocated by a relationship” leads to asthma or lung cancer, where being unable to let go of something results in irritable bowel syndrome, constipation, ulcerative colitis or colon cancer.

At the Arizona Center for Advanced Medicine, not only do we treat the body with therapies that help heal the physical illness, we also make every effort to help our patients make these stress-linked connections, so that they can heal on all levels.

Hear from an actual Arizona Center for Advanced Medicine cancer patient in the video below, or click here for video channel version >> http://goo.gl/uQk1k.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

Sources:

[1] Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001 Apr;48(4):526-35.

[2] Liguori, M.; Solinas, G.; Germano, G.; Mantovani, A.; Allavena, P. Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma. Cancers 2011, 3, 3740-3761.

[3] Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P (2010) Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biol 8(12): e1000562. doi:10.1371/journal.pbio.1000562

[4] Romero C, Friedman LC, Kalidas M, Elledge R, Chang J, Liscum KR. Self-forgiveness, spirituality, and psychological adjustment in women with breast cancer. J Behav Med. 2006 Feb;29(1):29-36. Epub 2005 Dec 15.

[5] http://video.foxnews.com/v/1217030696001/is-cancer-linked-to-not-forgiving/

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More information throughout our Arizona Center for Advanced Medicine sites…

View “FOOD 101 – Genetics, Addiction, and Politics” Click here >> http://goo.gl/HE7lJ .

View FOOD 201 – Is Organic Really Better?” Click here >> http://goo.gl/onbvN .

View Insulin Potentiation Therapy for Cancer” Click here >> http://goo.gl/twLvk .

View several articles on GMO Food. Click here >> http://goo.gl/yx0YT .

View VideoInsulin Potentiation Therapy for Cancer” Click here >> http://goo.gl/Bl3fm .

View video of a discussion with an Arizona Center for Advanced Medicine patient, click here >> http://goo.gl/Hh08V .

We have included below some additional informative support articles…

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Oxidative stress, inflammation, and cancer: how are they linked?

Source

Department of Experimental Therapeutics, The University of Texas MD AndersonCancerCenter, Houston, TX77030, USA.

Pubmed logo

Abstract

Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary diseases. Oxidative stress can activate a variety of transcription factors including NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2. Activation of these transcription factors can lead to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules. How oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell, tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis, and stem cell survival is the focus of this review. Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.

View the complete article, click here >> http://goo.gl/3G2dT .

LogoPubMed

New insights on oxidative stress in cancer.

Source

CEINGE Biotecnologie Avanzate, via Comunale Margherita 482, 80145 Naples, Italy.

Abstract

Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed.

View the complete article at PubMed, click here >> http://goo.gl/lxPEx .

LogoPubMed

The risk of colorectal cancer in ulcerative colitis: a meta-analysis.

Source

Gastrointestinal Research Unit, LeicesterGeneralHospital

Abstract

BACKGROUND AND AIMS:

Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have investigated this risk and reported widely varying rates.

METHODS:

A literature search using Medline with the explosion of references identified 194 studies. Of these, 116 met our inclusion criteria from which the number of patients and cancers detected could be extracted. Overall pooled estimates, with 95% confidence intervals (CI), of cancer prevalence and incidence were obtained using a random effects model on either the log odds or log incidence scale, as appropriate.

RESULTS:

The overall prevalence of CRC in any UC patient, based on 116 studies, was estimated to be 3.7% (95% CI 3.2-4.2%). Of the 116 studies, 41 reported colitis duration. From these the overall incidence rate was 3/1000 person years duration (pyd), (95% CI 2/1000 to 4/1000). The overall incidence rate for any child was 6/1000 pyd (95% CI 3/1000 to 13/1000). Of the 41 studies, 19 reported results stratified into 10 year intervals of disease duration. For the first 10 years the incidence rate was 2/1000 pyd (95% CI 1/1000 to 2/1000), for the second decade the incidence rate was estimated to be 7/1000 pyd (95% CI 4/1000 to 12/1000), and in the third decade the incidence rate was 12/1000 pyd (95% CI 7/1000 to 19/1000). These incidence rates corresponded to cumulative probabilities of 2% by 10 years, 8% by 20 years, and 18% by 30 years. The worldwide cancer incidence rates varied geographically, being 5/1000 pyd in the USA, 4/1000 pyd in the UK, and 2/1000 pyd in Scandinavia and other countries. Over time the cancer risk has increased since 1955 but this finding was not significant (p=0.8).

CONCLUSIONS:

Using new meta-analysis techniques we determined the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children. We found a non-significant increase in risk over time and estimated how risk varies with geography.

View the entire article, click here >> http://goo.gl/3B91d .

logoMDPI-logo

Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma

Abstract: Tumor-Associated Macrophages (TAM) are key components of the reactive stroma of tumors. In most, although not all cancers, their presence is associated with poor patient prognosis. In addition to releasing cytokines and growth factors for tumor and endothelial cells, a distinguished feature of TAM is their high-rate degradation of the extra-cellular matrix. This incessant stroma remodelling favours the release of matrix-bound growth factors and promotes tumor cell motility and invasion. In addition, TAM produce matrix proteins, some of which are typical of the neoplastic tissues. The gene expression profile of TAM isolated from human tumors reveals a matrix-related signature with the up-regulation of genes coding for different matrix proteins, as well as several proteolytic enzymes. Among ECM components are: osteopontin, osteoactivin, collagens and fibronectin, including also a truncated isoform of fibronectin termed migration stimulation factor. In addition to serve as structural proteins, these matrix components have key functions in the regulation of the vessel network, in the inductionof tumor cell motility and degradation of cellular debris. Among proteolytic enzymes are: matrix metalloproteases, cathepsins, lysosomal and ADAM proteases, and the urokinase-type plasminogen activator. The degrading activity of TAM, coupled to the production of bio-active ECM proteins, co-operate to the build-up and maintenance of an inflammatory micro-environment which eventually promotes tumor progression.

View the entire article, click here >> http://goo.gl/jlvLE .

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Cancer cells dupe the body’s immune system

Cancers may be wounds that never heal, suggest the first live images of tumours forming.

It seems individual cancer cells send out the same distress signals as wounds, tricking immune cells into helping them grow into tumours. The finding suggests that anti-inflammatory drugs could help to combat or prevent cancer.

“Lifelong, if you take a small quantity of something that suppresses inflammation, such as aspirin, it could reduce the risk of cancer,” says Adam Hurlstone of the University of Manchester, UK.

When tissue is wounded or infected it produces hydrogen peroxide. White blood cells called leukocytes are among the first cells to react to this trigger, homing in to kill the infectious agent, clean up the mess and rebuild damaged tissue. At first, the tissue becomes inflamed, but this subsides as the wound is cleared and rebuilding continues.

Now, a study in zebra fish shows that this process is also instigated and sustained by tumour cells.

Hurlstone and colleagues genetically engineered zebra fish so that skin cells and leukocytes would glow different colours under ultraviolet light. Some zebra fish were also engineered to have cancerous skin cells.

The team found that the cancerous skin cells secreted hydrogen peroxide, summoning leukocytes which helped them on their way to becoming a tumour. When the team blocked hydrogen peroxide production in the zebra fish, the leukocytes were no longer attracted to cancerous cells and the cancer colonies reduced in number.

More alarmingly, the researchers found that healthy skin cells adjacent to the cancerous ones also produced hydrogen peroxide, suggesting that cancer cells somehow co-opt them into triggering inflammation.

View the entire article, click here >> http://goo.gl/vJwo9 .

LogoPLOS

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

Abstract

It has not previously been possible to live image the earliest interactions between the host environment and oncogene-transformed cells as they initiate formation of cancers within an organism. Here we take advantage of the translucency of zebrafish larvae to observe the host innate immune cell response as oncogene-transformed melanoblasts and goblet cells multiply within the larval skin. Our studies indicate activation of leukocytes at very early stages in larvae carrying a transformed cell burden. Locally, we see recruitment of neutrophils and macrophages by 48 h post-fertilization, when transformed cells are still only singletons or doublets, and soon after this we see intimate associations between immune and transformed cells and frequent examples of cytoplasmic tethers linking the two cell types, as well as engulfment of transformed cells by both neutrophils and macrophages. We show that a major component of the signal drawing inflammatory cells to oncogenic HRASG12V-transformed cells is H2O2, which is also a key damage cue responsible for recruiting neutrophils to a wound. Our short-term blocking experiments show that preventing recruitment of immune cells at these early stages results in reduced growth of transformed cell clones and suggests that immune cells may provide a source of trophic support to the transformed cells just as they do at a site of tissue repair. These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds.

Author Summary

The translucency of zebrafish larvae allows us to live image the earliest dynamic interactions between host innate immune cells and oncogene-transformed cell clones as they first establish themselves as the precursors of full-blown cancer. These early associations manifest via cytoplasmic tethers between an immune cell and a transformed cell, and occasional phagocytic engulfment. Immune cells are first attracted to transformed cells at surprisingly early stages, before transformed cells have had a chance to form clones and are thus still singletons or doublets. We show that the key attractant is hydrogen peroxide (H2O2), which was also recently shown to be the essential early damage signal responsible for drawing neutrophils to wounds. Tissue transplantation experiments allow us to test which cells are responsible for generating the H2O2 attractant, and we show that both transformed cells and their otherwise healthy neighbors contribute. Blocking H2O2 synthesis, either pharmacologically or by morpholino-mediated knockdown of DUOX, the enzyme responsible for H2O2 synthesis in larval skin, very significantly reduces the numbers of neutrophils and macrophages drawn to transformed cell clones, and this results in reduced numbers of transformed cells, suggesting that innate immune cells play a trophic and/or support role in early transformed cell growth.

View the entire article, click here >> http://goo.gl/2U9T4 .

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Self-forgiveness, spirituality, and psychological adjustment in women with breast cancer.

Source

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA. romeroc@bcm.tmc.edu

Abstract

We evaluated whether a self-forgiving attitude and spirituality were related to psychological adjustment among 81 women being treated for breast cancer at a medical oncology clinic in a county general hospital. Both a self-forgiving attitude and spirituality were unique predictors of less mood disturbance and better quality of life (p’s < 0.001). These results are consistent with previous research that has demonstrated a positive relationship between spirituality and well-being. The findings also suggest that self-forgiveness should be explored experimentally to determine whether it can protect against the psychological effects of breast cancer-related stress. Interventions targeting these characteristics could improve the quality of life and alleviate stress, especially in women with breast cancer in public sector settings.

View the entire article, click here >> http://goo.gl/3xRtA .

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

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Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Cancer is an Environmental Disease. Cancer Series #16. Featured by the Arizona Center for Advanced Medicine Cancer center providing integrated medical treatment for cancer at our Scottsdale (Phoenix), AZ, center. Call 480-240-260.

Cancer16

Cancer Series #16 – Cancer is an Environmental Disease.

Submitted by as part of the 2012 Cancer Series of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

In 2012, cancer has become the second most common cause of death in the United States, right after heart disease.[1]

Our bodies, as part of the normal metabolic process, produce anywhere from a few hundred to perhaps 10,000 cancerous cells each day. The immune system has the ability to recognize every one of those aberrant cells and remove them – if it is functioning properly. There is universal Cancer16-chartagreement that cancer is a failure of the immune system. Cancer is also very similar to pregnancy – we should make antibodies to the fetus because it is a foreign body inside us, but we don’t make antibodies to our own infants. Why not? Cancer has been around for thousands of years, but it has gone from being rare to being commonplace. Its growth parallels the growth of industrialized economies which introduced heavy metals and unnatural chemicals into the environment, and began to industrialize and process food. Our immune systems were not designed to handle the bombardment of modern toxins combined with lack of nutrient-dense food.

In 1971, President Richard Nixon announced a “war on cancer” with the goal that cancer would be cured by 1976. Since then, the National CancerCancer16-Nixon Institute, the federal government’s main cancer research entity, has spent more than $105 billion. And other government agencies, universities, drug companies and philanthropies have spent billions more. Yet the death rate for cancer, adjusted for the size and age of the population, dropped only 5 percent from 1950 to 2005.[1] And the rate for many cancers has actually increased – most notably human papillomavirus (HPV)-related oropharyngeal cancer; esophageal adenocarcinoma; melanoma of the skin; and cancers of the pancreas, liver and intrahepatic bile duct, thyroid, and kidney and renal pelvis.[2]

Today, according to the National Cancer Institute, cancer will affect 1 in 2 men and 1 in 3 women in the United States. Cancer is now the number one cause of death in children between the ages of 1 and 14, right after congenital abnormalities and peri-natal conditions.[1]

For well over half a century mainstream medicine has promised that a cure or major breakthrough for cancer was just around the corner. So why can we not get around the corner?

At the Arizona Center for Advanced Medicine we can help you turn the corner – modify your risk – improve your health – and treat the disease, all at the same time, and in the same place. Cancer16-Immun

We help you to determine what is a healthy diet for you as an individual. If you are a blood type O, we do not remove all animal protein from your choices. We do restrict quantities, but we do not eliminate it. We encourage intake of vegetables and fruits, but we do not insist on an entirely raw foods diet for everyone. We do encourage you to eliminate all chemicals, all colorings and additives, all ingredients which you cannot pronounce, anything with initials listed in the ingredients.

For certain people we encourage a diet which eliminates common food allergens. For others, we recommend food allergy testing.

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View more information on Food Allergy Testing, click here >> http://goo.gl/x3ajv .

We encourage testing to determine whether there are functional  nutritional deficiencies – what Jeffrey Bland calls “potholes in the road of life” – that need to be corrected. We do not look at your levels relative to 95% of the population, because we realize full well that some of us have genetic needs that go far beyond the “reference range” for adequate health. View an article on MTHFR, click here >>  http://goo.gl/4maBt .

At Arizona Center for Advanced Medicine, we help you to look at all levels of the dysfunction, to determine where is the most effective place to start working.

This may well be on the physical level. If there are nutritional deficiencies, we often will correct these through IV Nutritional treatments.

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View more information on Nutritional treatments, click here >>  http://goo.gl/GYp3Z .cancer16-IVnutr

We make every effort to base these therapies on results of testing, so that we are not simply flying blind. We also make use of extensive oral supplementation to restore the health of the body. All our suppliers have Good Manufacturing Practices (GMP) certification for their products. Our Compounding Pharmacies are all registered and in good standing with the states in which they are located. They are all certified by outside bodies for quality control.

For our patients with cancer, we use forms of chemosensitivity testing which are not yet available in the United States, so that we can choose the best possible combination of drugs and supplements to treat the individual’s particular cancer.

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View more information on IPT where we discuss RGCC and Biofocus testing, click here >> http://goo.gl/mST5W.

Furthermore, we use Insulin Potentiation Therapy, Low Dose (IPTLD™) to achieve the most effective dose of the most effective chemotherapeutic agent inside the cancer cell, sparing the normal cells from most of the devastating effects of chemotherapy.

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View more information on IPTLD, click here >> http://goo.gl/ezb6D .

Dysfunction may also be on the emotional or mental level – dealing with old traumatic experiences, or with mindsets which have a hard time admitting the possibility of anything outside the box is an interesting – and fruitful – experience for all of us.

We have a multitude of modalities available for our patients – from guided imagery and hypnosis to biophotonic energy treatments – to help them determine the root cause of their illness. We help our patients to detach themselves from whatever emotional attachments to “old stuff” they still have, so that they can move forward in health, leaving the ball and chain of old emotional distress behind.

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View more information on guided imagery and hypnosis, click here >> http://goo.gl/qhkcI.

At the Arizona Center for Advanced Medicine we provide truly integrative cancer care, for body, mind and spirit.

View a short Arizona Center for Advanced Medicine I.P.T. treatment video below…

Hear from an actual Arizona Center for Advanced Medicine cancer patient in the video below, or click here for video channel version >> http://goo.gl/uQk1k.

To view the Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/8AU1g

Sources:

[1] Downloaded 10/20/2012 from http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf

[2] Gina Kolata; Forty Years War-Advances Elusive in the Drive to Cure Cancer, New York Times, April 23, 2009

[3] Cancer Facts and Figures 2012, available online at http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf

[4] Downloaded 10/20/2012 from http://www.childdeathreview.org/nationalchildmortalitydata.htm

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

View the entire Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/VFLmD.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Public relations and cancer. Cancer Series #15. Featured by Arizona Center for Advanced Medicine Cancer Center providing integrated medical treatment for cancer. Call 480-240-2600.

Cancer15

The Cancer Series #15 – Public Relations and Cancer.

Submitted by as part of the ’Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

The “Public Relations and Cancer” article below appeared in 1998. Has anything changed since then?

Breast Cancer Awareness Month still happens in October every year.

This phenomenon was launched in 1987 by Imperial Chemical Industries, a British chemical company. Has anyone noticed how the literature does not publish any information about environmental or chemical causes of cancer, breast cancer or otherwise?

We have information about breast cancer, both treatment and causes, in other segments of this website.

Now it is time to learn about the sponsors, and to wonder about the purpose of the awareness month.

Is there anyone on the planet who is not aware that breast cancer is a major problem in the world?

So who exactly is spending all the money on promotion of this awareness month? And why are they spending so much money?

Astra-Zeneca, the subsidiary of Imperial Chemical Industries, appears to have control over what is publicized and released to the press during the Breast Cancer Awareness Month. Zeneca is the sole owner of a Selick, a chain of health care clinics whose major purpose is to treat cancer.[1]

“NBCAM was founded in 1985 as a partnership between the American Cancer15-ZenecaLogoCancer Society and the pharmaceutical division of Imperial Chemical Industries (now part of Astra Zeneca, maker of several anti-breast cancer drugs). The aim of the NBCAM from the start has been to promote mammography as the most effective weapon in the fight against breast cancer.” ~ Wikipedia[2] When the “contact us” link is clicked, an e-mail option comes up on the screen, nbcam@astrazeneca.com which leads one to suspect that perhaps Astra Zeneca is pretty high up in the National Breast Cancer Awareness Month chain.

General Electric, a major polluter of carcinogenic PCBs in a 200 mile stretch of the Hudson River, sells upwards of $100 million annually in mammography machines.(3) To quote from their literature: “We envision a day when cancer is no longer a deadly disease. Building on GE’s cancer commitment, we aim to bring the most promising cancer ideas to market, develop technologies that improve accuracy of diagnosis and enable more effective treatment decisions, and empower doctors and patients with better information,” … John Dineen, President and CEO of GE Healthcare. And from their website: “Early Health is focused on enabling earlier diagnosis and more effective treatment of disease so that people live longer and lead more productive, fulfilling lives.”

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Downloaded from the website, click here >> http://goo.gl/Ckndx .

Monsanto, a world leader in the field of genetically modified seeds and chemical pesticides, shown – in a recent long-term study of the effect of GMO corn on rats (4) – to promote the development of breast cancer. Ironic that they should be one of the sponsors of the awareness month. You may wish to read the recent blog piece on that study by Eric Seralini and colleagues.

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These are the American Cancer Society’s guidelines for breast cancer.

  • Yearly mammograms are recommended starting at age 40 and continuing for as long as a woman is in good health.
  • Clinical breast exam (CBE) about every 3 years for women in their 20s and 30s and every year for women 40 and over.
  • Women should know how their breasts normally look and feel and report any breast change promptly to their health care provider. Breast self-exam (BSE) is an option for women starting in their 20s.
  • Some women – because of their family history, a genetic tendency, or certain other factors – should be screened with MRI in addition to mammograms. (The number of women who fall into this category is small: less than 2% of all the women in the US.) Talk with your doctor about your history and whether you should have additional tests at an earlier age.

So who exactly benefits from the publicity surrounding the “Breast Cancer Awareness Month”?Cancer15-breastcancermonth

It is an occasion to get together and feel as though we are doing something to promote the health of our friends and relations with breast cancer – and to remember those who died – and to raise money for research…

What is not so clear is exactly what kind of research are we raising money for, and whether the money is actually going to do anything specific for our loved ones. Pharmaceutical companies benefit. Radiology equipment manufacturers benefit. Do patients actually benefit? Is the rate of breast cancer falling?

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View our extensive Thermography website with more information on the procedure, click here >> http://goo.gl/DESQz.

To view the Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/8AU1g.

“How do I help myself” with Dr Martha Grout, view video below…

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View other Women’s Wellness articles, click here >> http://goo.gl/FOyk4 .

Sources:

[1] http://www.answers.com/topic/salick-health-care-inc

[2] http://en.wikipedia.org/wiki/National_Breast_Cancer_Awareness_Month

Cancer15-thinkB4pink

Public Relations and Cancer

by Judy Brady (article appeared in the October 1998 issue of The Source)

Excerpted with permission from the Women’s CancerResourceCenter’s Center News, Fall 1997

Breast Cancer Awareness Month (BCAM) is here. For those who don’t know, BCAM is a very slick public relations campaign designed by Zeneca’s once-parent company, Imperial Chemical Industries. Zeneca, now an independent chemical/pharmaceutical corporation, has been Cancer15-ZenecaLogojoined by many other companies who have discovered that aligning themselves with the breast cancer movement is good for their public image and thus, their profit margins. Zeneca maintains control and final veto power over the financing and publicity of BCAM and its message: raise more money for research and get a mammogram. It’s a smooth move for an outfit like Zeneca. These folks are the fourth largest producer of pesticides in the U.S., the manufacturer of the most widely prescribed drug for breast cancer (tamoxifen, also listed under Proposition 65 as a carcinogen), and now sole owner of Salick, Inc., a management company which runs a chain of cancer care centers. With BCAM it’s got breast cancer all wrapped up in the pretty little pink ribbon. And it gets thousands of well-meaning women to wear that pink ribbon, converting those women into tools for the cheapest public-relations masquerade ever designed.

The principal purpose of BCAM is to divert attention from the causes of the cancer epidemic (like pesticides produced by Zeneca and ionizing radiation from Hanford’s government-owned nuclear reactors) and focus instead on that which is profitable for the industry (e.g., drugs and mammograms). Since this ploy has been highly successful, other industries and organizations have followed suit and joined in the chorus of denial. After all, you’ve got to protect your investments.

Here are a few examples:

It is finally coming to light that Americans have been irradiated to a much greater extent than most of us have known. For instance, the 1986 Chernobyl accident is by conservative estimate responsible for a 30% increase in leukemias among American children.1 When my first child was born in Iowa (25 years earlier), the doctors were anxious that I breastfeed instead of using a bottle because they feared that formula had been contaminated by Strontium 90 — fallout from nuclear bomb testing. Now we find that people as far away as the East Coast states were also exposed. But the nuclear industry has a powerful friend in the American Cancer Society (ACS). One of the organization’s vice presidents, Dr. Clark Heath, who can always be counted upon to defend industry, says, “I would not be greatly concerned.”2

We in California are still facing the possibility of a nuclear waste dump in WardValley, which will definitely leak and absolutely guarantee many more cancers a few years down the road.

Harvard University, which enjoys a reputation as one of the world’s most prestigious academic institutions, recently released from the Harvard Center for Cancer Prevention a report on cancer which made the astonishing announcement that only 2% of cancers were due to “environmental pollution.” That’s puzzling until you see the list of funders for the Harvard Department of Health Policy and Management which reads like the Fortune 500 of industrial polluters: Chemical Manufacturers Association, Chevron, Dow Chemical, DuPont, Monsanto, Texaco, etc.3

There are more ways than one to cover up the causes of cancer and protect industry profits. The ACS does it by endorsing products for money. They recently made a $4 million deal with a nicotine-patch company and Florida orange juice companies for the use of their name in commercials. The orange juice commercials tout the wonders of Vitamin C, but needless to say, the ACS never supported Linus Pauling when he proposed that it could prevent cancer. And there is, of course, no mention of the pesticides used in Florida orange groves, Monsanto’s Round-Up (glyphosate, which produces cancer in test animals) being the most common.

Then there’s the Susan G. Komen Breast Cancer Foundation, which indiscriminately accepts money from polluting industries.4 Every year in October they stage the multimillion dollar “Race for the Cure” in cities all around the country. The event promotes mammograms despite the fact that even so well-known a breast cancer specialist as Susan Love does not advocate screening mammograms for premenopausal women.5 There is never a word about the causes of cancer in any of the promotional materials for the race.

In April the Komen Foundation is going one better; this year they are staging the “Drive for the Cure.” In a deal made with BMW, the Komen Cancer15-komanFoundation hopes to raise $1 million. In each city in nearly every single state, guests will be invited to test drive specially marked BMW cars, and for each mile driven the Komen Foundation will get one dollar. True to form, the Komen Foundation ignores the fact that cars and cancer are like matches and fire—one is sure to produce a certain amount of the other. The chemical benzo(a)-pyrene is part of the exhaust of cars, and it is one of the most powerful carcinogens known. That same chemical, present also in cigarette smoke, has been isolated as the element which causes cells in the lungs of smokers to become cancerous, and it undoubtedly figures in the lung cancers of nonsmokers, largely because of gas-powered vehicles. It was connected directly to breast cancer by the Peralta Cancer Research Institute in the 1980s.

Unfortunately, some grassroots cancer groups, often chronically underfunded, are also lured into overlooking cancer causes by the promise of a few more greenbacks. For instance, the Breast Cancer Fund (which lists Chevron as one of their corporate supporters) is hosting a fundraising golf tournament (in October, naturally) at the Crystal Springs Golf Course. They seem to have forgotten—perhaps they never knew?—that breast cancer among women golfers has become a serious issue because golf courses are routinely soaked with herbicides and pesticides, ten of which, according to scientists with the National Coalition Against the Misuse of Pesticides, are known carcinogens.6

At the First World Conference on Breast Cancer in Kingston, Ontario, a French corporation, Rhône-Poulenc Rorer, had a booth among the breast cancer groups. Rhône-Poulenc Rorer is one of the largest chemical corporations in the world, specializing in the production of organochlorine pesticides. They have one plant in West Virginia identical to the Union Carbide plant in Bhopal, India—which leaked thousands of pounds of the deadly chemical methyl isocynate into the air 11 years ago—and the West Virginia plant is the only one in the world that has taken no safety measures to protect the surrounding community.7 But Rhône-Poulenc Rorer has given money to the National Alliance of Breast Cancer Organizations. Allowing them a presence at the conference in Kingston was a coup for their public image.

The “art” of public relations creates an effective cover-up for the dirty practices of Rhône-Poulenc Rorer, Zeneca, government, industry and others evading questions of primary cancer causation in favor of profits.

Sources:

1 British Medical Journal, 1997; 314:1202.

2 “Nuclear Test ‘Hot Spots’ Probably All Over Country,” San Francisco Chronicle, July 26, 1996.

3 Crowley, Ellen, “Follow the Money,” Women’s Community Cancer Project Newsletter, Spring 1997.

4 Including Chlorine Chemical Council, a trade association for the chemical/pesticide industries.

5 “Mammography Madness,” Women’s Health Advocate Newsletter, May 1997.

6 Porter, Jerry, “LPGA Learns Realities of Breast Cancer,” USA Today, Nov. 7, 1991.

7 A letter from the Cancer Prevention Coalition to the Women’s Environment and Development Organization, Feb. 24, 1995.

View the original article, click here >> http://goo.gl/ocwe6 .

LogoNaturalNews

Think Before Going Pink: Many Breast Cancer Awareness Sponsors Profit from Cancer Article

By Natural News

As we find ourselves once again awash in a sea of pink for Breast Cancer Awareness Month (BCAM), few people who participate, donate or buy pink-themed products are aware that BCAM has always been a deliberate deception – a “pinkwash” which helps “do-gooder” sponsors hide their own culpability while promoting products which cause cancer.

In the beginning

Breast Cancer Awareness Month (BCAM) was launched in 1987 by Imperial Chemical Industries (ICI), a British chemical company which has been a world leader in manufacturing cancer-causing pesticides, plastics and other products. From day one, ICI and later spin-off Zeneca have used BCAM to direct research and prevention efforts away from chemical carcinogens.

To this day, not a word can be found in any of the BCAM literature suggesting that decreasing exposure to chemical carcinogens or dietary changes can help play a role in cancer prevention.

Examples of BCAM sponsors who promote cancer causing products:

General Electric (GE)

GE, a major polluter of carcinogenic PCBs in a 200 mile stretch of the Hudson River, sells upwards of $100 million annually in mammography machines. BCAM emphasizes encouraging yearly mammograms. The trademark slogan is “Early Detection is Your Best Prevention.” Though it is too late to prevent cancer once it has been detected, 37 percent of American women believe that mammograms somehow prevent breast cancer.

While mammograms have never prevented a single instance of cancer, radiation from routine mammography causes tens of thousands of cases of breast cancer each year. The National Cancer Institute reports that mammography may cause 75 cases of breast cancer for every 15 it identifies in younger women. Additionally, mammograms misidentify tumors 70 percent of the time, resulting in huge numbers of unnecessary and invasive biopsies.

Monsanto

Biotech giant Monsanto is a major sponsor BCAM’s high profile event, the Race for the Cure. At the same time, Monsanto reaps huge profits from products which cause breast and other cancers. A study published in the October, 2012 edition of the journal Food and Chemical Toxicology provided unprecedented evidence of the cancer causing dangers of the combination of Monsanto’s genetically modified corn and it’s herbicide Roundup.

Cow’s treated with Monsanto’s genetically engineered rBGH growth hormone produce milk with up to 10 times the normal Insulin-like Growth Factor I (IGF-1). IGF-1 has been identified as a leading risk factor for breast cancer as well as other cancers. Studies have shown that women with elevated levels of IGF-1 are seven times more likely to develop pre-menopausal breast cancer.

DuPont

DuPont, another huge chemical company and major polluter, supplies much of the film used in mammography machines. Like GE, DuPont aggressively promotes mammography screening of women in their 40s, despite the risk of its contributing to breast cancer in that age group.

The cosmetic giants

Cosmetic and body care companies, including such industry powerhouses as Estee Lauder, Avon, Revlon, and Mary Kay annually market pink-ribboned products during BCAM. Many of those same products contribute to breast and other cancers.

Hormone-mimicking chemicals such as parabens and phthalates found in cosmetic and body care products increase the risk of breast cancer and cause a broad range of birth defects. A study published in the Journal of Applied Toxicology in 2012 detected paraben esters in 99 percent of breast cancer tissues sampled.

Other cancer causers

In addition to the above list, a host of other sponsors also promote their cancer-causing products as part of BCAM, including KFC, Coca Cola, alcoholic beverage makers and many others.

Learn more by viewing the entire article, click here >> http://goo.gl/4aN0O.

LogoBusinessWire

GE Healthcare Mobilizes ‘GE Global Pink Ribbons’ to Support Breast Cancer Awareness Month

CHALFONT ST. GILES, England – Tuesday, October 2nd 2012

GE Healthcare today announced its second ‘GE Global Pink Ribbons’ campaign will run in over 40 global locations during October 2012.

Building on the success of last year’s events, several thousand GE employees will come together to form ‘Human Ribbons’ and visually logoGEhealthcaredemonstrate the global fight against the disease during Breast Cancer Awareness Month. New countries taking part this year include Egypt, Venezuela and Ukraine. To follow the activities, see how the importance of awareness and early detection of breast cancer is being raised visit the GE Healthcare Newsroom and Breast Cancer Mosaic site – which is a dedicated site created to share stories from breast cancer survivors, family members and physicians to increase awareness around breast cancer and to inspire those who are going through a difficult time.

“We envision a day when cancer is no longer a deadly disease. Building on GE’s cancer commitment, we aim to bring the most promising cancer ideas to market, develop technologies that improve accuracy of diagnosis and enable more effective treatment decisions, and empower doctors and patients with better information,” said John Dineen, President and CEO of GE Healthcare.

Dineen continued, “Emphasis on awareness building and early diagnosis will significantly enhance the effectiveness of treatment and reduce healthcare costs. The Global Ribbons campaign is important as it spreads the powerful message that early detection can save lives.”

Awareness of the importance of early detection of breast cancer continues to be an important issue in both developed and developing countries; as worldwide breast cancer remains the most common invasive cancer in women. In 2008, breast cancer caused almost 460, 000 deaths worldwide, almost 14% of cancer deaths in women. 1 Lack of access to appropriate facilities, up-to-date imaging technologies or trained medical professionals mean that even today two-thirds of all women around the world must forgo regular breast screenings. In addition to raising awareness during Breast Cancer Awareness Month, GE Healthcare is committed to reaching many of these women through a series of in-country partnerships with governments, NGOs and local health partners that can help mobilize efforts on the ground in regions.

In addition to these “GE Global Pink Ribbons” events, GE Healthcare raises awareness around the battle against cancer through multiple online and social media channels.

The Get Fit competition encouraged individuals and teams to post their healthy lifestyle choices on Twitter, Weibo or Facebook using the #GetFit hashtag; reinforcing the importance of a positive healthy lifestyle in cancer prevention. Get Fit cancer country ambassadors were showcased on Pinterest.

GE recently launched the Healthy Share Facebook App. This new tool is a channel for people to share health goals, track progress against goals and use friends as sources of inspiration and motivation toward better health.

In an effort to educate about the importance of asking questions for those diagnosed with cancer, and inform about how individualized cancer diagnostics and treatments can help drive positive outcomes, Is My Cancer Different? has been established as a resource.

Later this month through the power of music, the company will launch an initiative based on Spotify, to support breast cancer patients.

GE Healthcare has been a recognized pioneer in the battle against cancer for over fifty years and last year announced a healthymagination commitment to help 10 million patients around the world by 2020. The investment commitment, 1bn over the next five years, is dedicated to R&D and delivery of better care for patients through expansion of its world-class technologies as well as advanced cancer diagnostic and molecular imaging capabilities.

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Images available click here >> http://goo.gl/A7b1A .

Sources:

1 “World Cancer Report”. International Agency for Research on Cancer, 2008

About GE Healthcare

GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our broad expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, drug discovery, biopharmaceutical logoGEhealthcaremanufacturing technologies, performance improvement and performance solutions services help our customers to deliver better care to more people around the world at a lower cost. In addition, we partner with healthcare leaders, striving to leverage the global policy change necessary to implement a successful shift to sustainable healthcare systems.Our “healthymagination” vision for the future invites the world to join us on our journey as we continuously develop innovations focused on reducing costs, increasing access and improving quality around the world. Headquartered in the United Kingdom, GE Healthcare is a unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employees are committed to serving healthcare professionals and their patients in more than 100 countries. For more information about GE Healthcare, visit our website at www.gehealthcare.com For our latest news, please visit http://newsroom.gehealthcare.com

View the entire article, click here >> http://goo.gl/nwCzl .

LogoAmerCancerSoc

American Cancer Society, Inc., Board of Directors 2011-2012

Officers

Chair of the Board, Cynthia M. LeBlanc, EdDCancer15-boardpic

President, W. Phil Evans, MD, FACR

Chair-elect, Gary M. Reedy

President-elect, Vincent T. DeVita, Jr., MD

Vice Chair, Pamela K. Meyerhoffer, FAHP

First Vice President, Tim E. Byers, MD, MPH

Second Vice President, Douglas K. Kelsey, MD, PhD, FAAP

Treasurer, Daniel P. Heist, CPA

Secretary, Robert R. Kugler, Esq.

Immediate Past Chair, Stephen L. Swanson

Immediate Past President, Edward E. Partridge, MD

Directors

LAY

MEDICAL

John Alfonso, CPA – Eastern 2013

Patricia K. Bradley, PhD, RN, FAAN – East Central 2013

Briggs W. Andrews, Esq.– South Atlantic 2012

Robert K. Brookland, MD – South Atlantic 2012

Vincent F. Barbetta, CLU, ChFC – New England  2013

Judith E. Calhoun, PhD, ARNP – High Plains 2013

Debra J. Cohen – Illinois 2013

Carmel J. Cohen, MD – Eastern 2012

Bryan K. Earnest – Midwest 2013

Diana S. Diaz, RN, MS – Mid-South 2012

Allen H. Henderson, PhD – High Plains 2013

Willie H. Goffney, MD, FACS – California 2012

Susan D. Henry, LCSW – Mid-South 2012

John W. Hamilton, DDS – Great West 2012

Jeffrey L. Kean – California 2012

Enrique Hernandez, MD – East Central 2013

Joseph R. Mahoney, CPA – Great Lakes 2013

Michael E. Kasper, MD, FACRO – Florida 2012

Linda Z. Mowad, RN – New England 2012

Clement S. Rose, MD – Illinois 2012

Scarlott K. Mueller, RN, MPH – Florida 2012

Donald K. Warne, MD, MPH – Midwest 2013

Robert E. Youle – Great West 2013

Maria J. Worsham, PhD, FACMG – Great Lakes 2013

Directors-at-Large

LAY

MEDICAL

Sheila P. Burke 2013

Michele Carbone, MD, PhD 2013

Marjorie Kagawa Singer, PhD, MA, MN, RN, FAAN 2012

Graham A. Colditz, MD, DrPH 2012

Sandra Millon Underwood, RN, PhD, FAAN 2012

Kevin J. Cullen, MD  2013

Haskell Sears Ward 2013

Maryjean Schenk, MD, MPH, MS 2012

logoEWG.org

From the EWG website, downloaded 10/10/2012

In August, President Obama signed into law the Honoring America’s Veterans and Caring for Camp Lejeune Families Act (H.R. 1627). This bill provides essential health benefits to veterans and their families made ill from one of the largest incidents of pollution in history. CampLejeune, a Marine Corps Base in North Carolina, is the site of the largest cluster of male breast cancer cases ever identified – which has been traced to one of the worst incidents of drinking water contamination in U.S. history.

The fight to get the legislation passed was documented in the award-winning film Semper Fi: Always Faithful. The documentary follows cancer survivor Mike Partain and retired Marine Jerry Ensminger as they learn about the contamination and take the fight for their families’ health to Capitol Hill.

Semper Fi: Always Faithful is available on Amazon. If you purchase it through EWG’s dedicated Amazon link, a portion of the sale will be donated to EWG at no extra cost to you.

Semper Fi: Always Faithful

To order click here >> http://goo.gl/odLr7 .

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

View the entire Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/VFLmD.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Mammography vs. Thermography. Cancer Series #14. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer141W

Cancer Series #14 – Mammography vs Thermography revisited – once again.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Cancer14-RadSymbolMedicine Cancer Center, Scottsdale (Phoenix), Az.

We have said for years that the only proven cause of cancer is ionizing radiation.[1],[2],[3] We have wondered for years why in the world women would subject themselves to having their breasts squashed and irradiated with ionizing radiation in order to screen for breast disease. We have imagined what would have happened to the test if this had been the screening tool for testicular or prostate cancer.

Now we have one more reason not to permit anyone to squash us and irradiate us year after year just to demonstrate the possibility of a disease which may in fact be induced by the very test we are employing to screen for it.

The Associated Press published an article on September 6, 2012 entitled “Radiation may up breast cancer risk in Cancer14-mammogramsome women”. The original work was published in the British Medical Journal on the same day. This publication recommended nuclear magnetic resonance imaging (MRI) instead of mammography for those women who have one of the BRCA mutations making them more susceptible to breast cancer – even without the exposure to ionizing radiation.

View the entire AP article, click here >> http://goo.gl/74uO8 .

The American Society for Clinical Oncology published an article in the ASCO Post entitled: Seeking Solution to the Dilemmas of Overdiagnosis and Overtreatment.[1] Their plea was for restraint in the treatment of DCIS (ductal carcinoma in situ), a very early and slow-growing  cancer which, in all likelihood, would not kill a woman in her lifetime. “…screening can reveal indolent disease, in which intervention is a net negative… The question becomes ‘What is the value of the finding?’”

View our extensive Thermography website with more information, click here >> http://goo.gl/DESQz .

Thermography has the benefit of showing inflammatory change many years before any lump can be palpated. It Cancer14-thermowill show inflammation, which can be treated with non-toxic therapies like low dose iodine, and can be monitored for improvement without risking ionizing radiation. Thermography is inexpensive, easy to do, available in the offices of those in the medical profession who do not choose to prescribe mammography. Thermography is less expensive than MRI which is now being used instead of mammography in Europe for examination of young women.

Arizona Center for Advanced Medicine reminds you, “Women have the choice”.

View the video… “Learning Alternative Medicine with Dr Grout at the Arizona Center for Advanced Medicine”, click here >> http://goo.gl/QJSi5 .

To view the Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/8AU1g.

View other Women’s Wellness articles, click here >> http://goo.gl/FOyk4 .

Sources:

[1] http://www.cancer.org/Cancer/CancerCauses/OtherCarcinogens/MedicalTreatments/radiation-exposure-and-cancer

[2] http://www.pnas.org/content/100/24/13761.long

[3] http://www.publichealth.va.gov/exposures/radiation/diseases.asp

[4] Piana R. Seeking Solutions to the Dilemmas of Overdiagnosis and Overtreatment. ASCO Post November 15, 2012, Volume 3, Issue 17. Downloaded 11/24/2012.

logoNBC

Radiation may up breast cancer risk in some women. LONDON (AP) — Mammograms aimed at finding breast cancer might actually raise the chances of developing it in young women whose genes put them at higher risk for the disease, a study by leading European cancer agencies suggests.

The added radiation from mammograms and other types of tests with chest radiation might be especially harmful to them and an MRI is probably a safer method of screening women under 30 who are at high risk because of gene mutations, the authors conclude.

The study can’t prove a link between the radiation and breast cancer, but is one of the biggest ever to look at the issue. The research was published Thursday in the journal BMJ.

“This will raise questions and caution flags about how we treat women with (gene) mutations,” said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. He and the society had no role in the research.

Mammograms are most often used in women over 40, unless they are at high risk, like carrying a mutation of the BRCA1 or BRCA2 gene. Having such a mutation increases the risk of developing cancer five-fold. About one in 400 women has the gene abnormalities, which are more common in Eastern European Jewish populations. Unlike mammograms, an MRI, or magnetic resonance imaging scan, does not involve radiation.

The breast cancer screening tests have been proven to save lives and are clearly beneficial for women aged 50 and over who have an average risk of breast cancer. Experts are divided about their value in women younger than 50.

Some studies have suggested women with the genetic mutations could be more sensitive to radiation because the genes are involved in fixing DNA problems. If those genes are damaged by radiation, they may not be able to repair DNA properly, raising the cancer risk.

In several European countries including Britain, the Netherlands and Spain, doctors already advise women with BRCA mutations to get MRIs instead of mammograms before age 30. In the U.S., there is no specific advice from a leading task force of government advisers, but the American Cancer Society recommends yearly mammograms and MRIs from age 30 for women with BRCA gene mutations.

In the BMJ study, European researchers followed nearly 2,000 women over 18 with one of the gene mutations in Britain, France and the Netherlands. Participants reported their previous chest X-rays and mammograms, Cancer14-nocancersymbolincluding the age of their first screening and the number of procedures. About 850 women were later diagnosed with breast cancer. Roughly half of them had X-rays while one-third had at least one mammogram, at an average age of 29.

The researchers did not have a breakdown of how many women were exposed to chest radiation before age 30 but estimated that for every 100 women aged 30 with a gene mutation, nine will develop breast cancer by age 40. They projected the number of cases would increase by five if all of them had one mammogram before age 30. But they cautioned their results should be interpreted with caution because most women didn’t have a mammogram before 30.

Researchers found women with a history of chest radiation in their 20s had a 43 percent increased relative risk of breast cancer compared to women who had no chest radiation at that age. Any exposure before age 20 seemed to raise the risk by 62 percent. Radiation after age 30 did not seem to affect breast cancer risk.

“We believe countries who use mammograms in women under 30 should reconsider their guidelines,” said Anouk Pijpe of the Netherlands Cancer Institute, one of the study authors. “It may be possible to reduce the risk of breast cancer in (high-risk) women by using MRIs, so we believe physicians and patients should consider that.”

The study was paid for by European cancer groups.

Lichtenfeld said the study wouldn’t immediately change advice from the American Cancer Society but said concerned women should talk to their doctor about their options. “It’s not possible today to make a blanket statement about what women (with the gene mutations) should do, but physicians and patients need to weigh the risks and benefits carefully,” he said.

He also warned that women who need scans involving radiation shouldn’t avoid them because of breast cancer fears.

“No one should think that they should never get an X-ray because they have the BRCA1 or 2 gene mutations,” he said. “Just be careful that the X-rays you get are really the ones that you need.”

View the entire article, click here >>  http://goo.gl/74uO8.

logoBMJ

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

Source

Netherlands Cancer Institute, Department of Epidemiology and Biostatistics, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

Abstract

OBJECTIVE:

To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations.

DESIGN:

Retrospective cohort study (GENE-RAD-RISK).

SETTING:

Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands,

PARTICIPANTS:

1993 female carriers of BRCA1/2 mutations recruited in 2006-09.

MAIN OUTCOME MEASURE:

Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire.

RESULTS:

In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00),cancer14-chart with a dose-response pattern. The risks by quarter of estimated cumulative dose <0.0020 Gy, ≥0.0020-0.0065 Gy, ≥0.0066-0.0173 Gy, and ≥0.0174 Gy were 1.63 (0.96 to 2.77), 1.78 (0.88 to 3.58), 1.75 (0.72 to 4.25), and 3.84 (1.67 to 8.79), respectively. Analyses on the different types of diagnostic procedures showed a pattern of increasing risk with increasing number of radiographs before age 20 and before age 30 compared with no exposure. A history of mammography before age 30 was also associated with an increased risk of breast cancer (hazard ratio 1.43, 0.85 to 2.40). Sensitivity analysis showed that this finding was not caused by confounding by indication of family history.

CONCLUSION:

In this large European study among carriers of BRCA1/2 mutations, exposure to diagnostic radiation before age 30 was associated with an increased risk of breast cancer at dose levels considerably lower than those at which increases have been found in other cohorts exposed to radiation. The results of this study support the use of non-ionising radiation imaging techniques (such as magnetic resonance imaging) as the main tool for surveillance in young women with BRCA1/2 mutations.

View the BRCA Fact Sheet, click here >> http://goo.gl/q4N6I.

View the entire article, click here >> http://goo.gl/fAjQl .

Hear from an actual Arizona Center for Advanced Medicine cancer patient, click here for video >> http://goo.gl/uQk1k.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

View the entire Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/VFLmD.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Why can’t we win the war on cancer? Cancer Series #13. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical caner treatment at our newly expanded Scottsdale (Phoenix), AZ, center. Call 480-240-2600.

Cancer Series #13 – Why can’t we win the war?

Submitted by as part of the 2012 Cancer Series of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

What can we learn from the “war on cancer” metaphor that has anything at all to do with cancer?

First, if it’s a war, then it’s a civil war – one part of us rebelling against another part of us.

What happens in a civil war? When the two sides fight, the whole country becomes devastated. We start talking about killing off whole populations of people –the Armenians in the Ottoman Empire during World War I, the Jews in Hitler’s Germany before and during World War II,  ten years ago the Tutsi in Hutu-led Rwanda, currently the Darfuri in Sudan.

But in fact, it’s not only the “enemy” who die. Plenty of “friendly” troops also bite the dust. The countryside is devastated, crops are destroyed, and famine rules the land.

Is it so different with current cancer therapies?

  • We try to kill off a population of cells – the cancer cells – which originally developed from our own body cells. They are our cousins, our own tribe.
  • Chemotherapy often does a pretty good job at killing cancer cells. The problem is that is does an equally good, or sometimes even better, job of killing our own cells – our hair, our mucous membranes, our intestinal (GI) tracts, our bone marrow and immune system.
  • The GI tract is so injured and inflamed that it can no longer function to absorb water and nutrients, or discriminate between useful and not useful, so it ends up just getting rid of  everything, with incapacitating diarrhea.
  • We lose weight – in medical terms, we develop cachexia – and are no longer able to maintain sufficient muscle mass to move around. Eventually we die of malnutrition – whether because we simply cannot absorb food, or because of some of the more extreme diets we try, in an effort to starve out the cancer cells.
  • Our bone marrow is so devastated that we no longer have sufficient shock troops to deal with infections that come down the pike. We die of chicken pox, or pneumonia, or infections caused by our own normally friendly intestinal bacteria.
  • We may survive the first round of the battle, only to develop a recurrence of the cancer – or a secondary cancer – years later, this time no longer responsive to the drugs that appeared to be effective on the previous round.

Why are we not winning this war?

Dr. Judy Garber, in an interview for the Boston Globe in April 2011, is quoted as saying: “Changing behavior turns out to be a whole lot harder than figuring out which molecule interferes with which gene. It’s not that people don’t want to, it’s just very hard to do. Patients always ask me: Isn’t there going to be a way to fix that gene? That’s going to take a while.”

Women from breast cancer prone families get the breast cancer about 10 years earlier than their mothers did. Same genes, different environment, different lifestyles.

Can we do anything about the genes? Probably not.

Can we do anything about our diet and lifestyle? Absolutely yes.

Should we be doing more frequent screening? To quote Dr. Garber again, “For many people it’s counterintuitive that more screening is not always better. .. [People] always feel they would be safer if we would just look more often but that’s not always the case. The more you look, the more you find, but not all you find is worth finding.”

In an article in Fortune magazine in 2004, Clifton Leaf, himself a Hodgkins Lymphoma survivor, writes: “Hope and optimism, so essential to this fight, have masked some very real systemic problems that have made this complex, elusive, relentless foe even harder to defeat. The result is that while there have been substantial achievements since the crusade began with the National Cancer Act in 1971, we are far from winning the war.”[1]

Mr. Leaf interviewed researchers, physicians and scientists, asking them to tell him what we could do to actually win the war. What he discovered was pretty appalling.

Virtually all these experts offered testimony that, when taken together, describes a dysfunctional “cancer culture”–a groupthink that pushes tens of thousands of physicians and scientists toward the goal of finding the tiniest improvements in treatment rather than genuine breakthroughs; that fosters isolated (and redundant) problem solving instead of cooperation; and rewards academic achievement and publication over all else.

At each step along the way from basic science to patient bedside, investigators rely on models that are consistently lousy at predicting success–to the point where hundreds of cancer drugs are thrust into the pipeline, and many are approved by the FDA, even though their proven “activity” has little to do with curing cancer.

Researchers talk about the heterogeneity of tumors – meaning that they can be composed of cells which have mutated DNA, each group of cells within a single tumor bearing a different genetic signature, making it extremely difficult to find a chemotherapeutic agent that will kill them all.

Eric Lander, of the Whitehead Institute’s Center for Genome Research in Cambridge, Mass, is quoted in the same article: “There are only, pick a number, say, 30,000 genes. They do only a finite number of things. There are only a finite number of mechanisms that cancers have. It’s a large number; when I say finite, I don’t mean to trivialize it. There may be 100 mechanisms that cancers are using, but 100 is only 100.”

But part of the problem is that the experiments are done on mice, not human beings. And despite the fact that both mouse and human are mammals, their genes are clearly different. The model is not a good model. Tumors grown experimentally in mice behave differently than tumors grown spontaneously in human.

Trillions of mice have been cured by experimental cancer drugs. But not trillions of humans.

So is the fault in the FDA which approves drugs based on drug trials in these flawed models? Or is the fault in the pharmaceutical companies which use the flawed models in their applications to the FDA?

It is not generally the original cancer that kills the patient, but rather the fact that cancer cells crawl or are surgically spilled into the bloodstream or into the lymph nodes and spread to distant organs. This process is called metastasis, and it is almost always metastatic disease that kills the individual, not the original tumor.

So why are we not researching the process of metastasis? We could be (a) discovering whether metastasis is an issue in any given patient, by means of testing of circulating tumor cells or (b) figuring out ways to prevent metastatic cells from latching on to new tissues and invading them.

In 2004, Mr. Leaf writes: “There are probably good biomarkers–proteins, perhaps, circulating in the body–that can tell us that cancer cells have begun the process of spreading to other tissues. As of yet, though, we don’t know what they are.”

In fact, tests of circulating tumor cells have been available in Europe and in Greece for many years.

RGCC was established in 2004 by Dr. Ioannis Papasotiriou in northern Greece. This laboratory has developed a method to identify, isolate and sort cells from peripheral blood, and to determine whether they are simply circulating tumor cells, or whether they also have cancer stem cell characteristics. Stem cells are the ones capable of migrating into distant tissues to create new and often genetically different tumors. They also have a way to grow the cells which are isolated, so that they can be tested against chemotherapeutic and so-called alternative, or botanical and biologic agents. Thus it is possible to get a very good idea as to which agents can be the most helpful in any given patient.[1]

Biofocus is a German laboratory which provides molecular analysis to determine whether circulating tumor cells are likely to be sensitive to specific families of chemotherapeutic and alternative agents. This lab provides an indirect test, but unlike the RGCC lab does not grow the circulating cells in tissue culture for direct analysis of kill rate.

Neither of these tests is accepted in the United States as valid, or even helpful, in determining potential chemotherapy for a patient with cancer. Insurance does not cover them, and few oncologists are guided by the results.

A search of PubMed for the terms “cancer stem cell” and “chemosensitivity” brings up on 1408 articles, the oldest published in 1976, most published since 2000. One article published in 2011 compared genetic tumor markers with actual tissue culture chemosensitivity testing, and concluded that actual chemosensitivity testing was significantly better at predicting patient response to drugs than were the genetic markers.

And we still have hardly any options for testing chemosensitivity in the United States. We who use this form of testing[1] are forced to send our specimens outside the country in order to get this valuable information.

How can we possibly win this “war on cancer” if we cannot define the condition of the enemy, or its number, or its weak points? If we wait for the tests to be validated by multiple placebo controlled double blind studies, we are liable to wait for many years before we see any meaningful data.

In the meantime, over 1500 people are dying of cancer every day[2], many of treatment-related complications. If they have to die of these treatment-related complications, at least they could die of a treatment  that has been shown to have some relevance to their particular individual tumor cells.

What if we are fighting the wrong war? What if the cancer is actually trying to send us a message? If we shoot the messenger, we’re liable never to hear the message it was trying to convey.

“I never asked to have cancer!” I hear you say.

“I am offended.”

“I can’t believe you would be so cruel, or so unthinking, or so uncompassionate, or so mean, or so small-minded as to suggest that I had some part to play in the development of my cancer. “

And yet…

“I know that I brought this on myself.” – from a patient with ovarian cancer who said she had pushed herself beyond her own limits.

If we can agree that illness arises in the emotional body – as many would say – then it behooves us to help our patients find those areas in which they have unfinished business, so that they can make the choice whether to let it go, or to hang on to it.

Not that letting go of the issues that troubles them is necessarily a cure – in the physical body – for cancer. Sometimes the disease is just too far advanced for the best of our medical science to reverse. But, at the very least, there may come some peace, some resolution of an issue that has troubled us all our life, and some hope for the future.

We only have control over our own actions, not those of anyone else – not our children, not our spouses, not our employers, not the person who denigrated or ignored our very existence.

We do have control over our own actions. We can choose to hold on to those old hurts. We can also choose to let them go. Whether we do so in life, or as we are approaching death is less important than what we choose to do, and what we choose to carry with us into the next life.

Arizona Center for Advanced Medicine Cancer Center reminds us, “We have the choice”.

View the video below to hear from an actual Arizona Center for Advanced Medicine cancer patient…

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g.

Sources:

[1] Downloaded from http://edition.cnn.com/2007/HEALTH/01/09/fortune.leaf.waroncancer3/index.html 8/26/2012. Why we’re losing the war on cancer [and how to win it].

[2] See www.rgcc-genlab.com for further information, and for papers published in the peer-reviewed literature

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. Read all ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Colon Cancer. Cancer Series #26. Featured by Arizona Center for Advanced Medicine. Treating 300+ holistic and medical treatments in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer26

Cancer Series #26 – Colon Cancer.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Colon cancer is the most frequent malignancy of the GI tract, and the second most frequent malignancy diagnosed in recent years. In the mid-1970s, the incidence of colorectal cancer was 60 cases per 100,000 population[1], and about 50% of people survived for 5 years after diagnosis. As of 2004, the incidence of went down to 48 cases per 100,000 population, largely because of increased use of colonoscopy to detect precancerous polyps earlier. It is still the third most commonly diagnosed cancer for both men and women (after breast and prostate). The National Cancer Institute estimates 143,460 people will be diagnosed with colorectal cancer in 2012, with an estimated 51,690 deaths. About one in three people die of their disease every year.

Risk factors for development of colon cancer

Colorectal cancer is associated with inflammation in the GI tract, as has been shown by the increased incidence of colorectal cancer in patients with ulcerative colitis.[2] Certain forms of familial colon cancer are associated with increased expression of the COX-2 inflammatory molecules in the gut.[3] Patients with higher levels of IGF-1 receptors have an increased risk of developing colorectal cancer.[4], [5] Composition of the bacterial flora of the GI tract is also believed to play a role in the development of both inflammatory bowel disease and cancer.[6] Genetics play some role – both in that form associated with polyps, and the form associated with the more difficult to diagnose flat lesions.[7]

Multiple other nutritional and environmental risk factors have been discovered over the years. Animal protein[8], alcohol[9], sugar, high body burden of heavy metals[10] are among the most prominent. At the Arizona Center for Advanced Medicine, we work with nutrition, as well as search for any toxins like heavy metals, which can serve as blocks to healing. Heavy metals are removed through chelation therapy. Nutritional work is part of the protocol of treatment, following the principles outlined in our FirstLine Therapy program.

What is the colon, and what purpose does it serve?

The colon is a muscular tube which originates during the 4th week of embryologic development from the endoderm, one of the outer layers of Cancer26-highlightthe embryo. It is one of the first organs to develop, after the brain. The intestinal tract has layers of smooth muscle, both circular and longitudinal, which serve to propel the food or waste toward its final destination. Between the two layers ride the autonomic nerves which manage both our digestion and our excretion functions without us

having to pay attention to these function. We have striated muscle, under voluntary control, in the mouth, the upper part of the esophagus, and in the lower part of rectum and anus.

The function of the colon is to separate solids from liquids, reabsorb the liquids and eliminate the solids – that which no longer serves the body. In a very real sense, constipation reflects the ability to hold onto the past, or the inability to let go of the past. One of the extraordinary things about the intestinal tract is that whereas much of it is NOT under voluntary control (small intestine, right side of colon), we actually do have voluntary control of both ends – the mouth and the anus.

We can choose what goes in, and we can choose what comes out. We can hold on to things if we so decide. Cancer26-cellsThe holding on may be on a conscious or subconscious levels, but it is under voluntary control. The nerves in those areas have both autonomic and voluntary connections with different kinds of muscle – both smooth and striated. Remember that we are energetic and spiritual beings with physical bodies. What happens on one level happens on all levels. There is a wonderful treatment in Chinese medicine called “External and Internal Dragons”, which is aimed at restoring physical, emotional, mental and spiritual balance to the body. One of the points used is for the colon – to eliminate on all levels those things which no longer serve a useful function, which are holding us back physically and emotionally.

Diagnosis

On physical examination, colorectal cancer may be suspected if we see blood in the stool, or an occult blood test is positive. Many conditions may manifest with blood in the stool, including hemorrhoids, infectious diarrhea, Crohn’s disease, ulcerative colitis, and other inflammatory bowel conditions. Rectal examination may show evidence of a mass if we are dealing with a cancer low in the colon. CT scan or MRI may show X-ray evidence of a mass. Colonoscopy can visualize a polyp or tumor, and allows for biopsy of the mass. However, none of the procedures will give a definitive diagnosis. Only examination of tissue under a microscope provides the diagnosis. Until we see microscopic evidence of abnormal tissue, we only have a suspicion.

Patients are given an estimate of prognosis, based on the staging of the tumor. Staging is based on tumor size in centimeters (T), number of positive lymph nodes (N) and the presence or absence of metastases (M) – this is called TNM staging, with stage one being T0, N0, M0 and stage IV being any size T, any number of N, and presence of metastases.

Cancer26-chartMany efforts have been made to diagnose a cancer without having to get a piece of the tumor surgically. Tumor markers are proteins which are sometimes expressed in high amounts in the circulating blood. If any of the markers is present, that is helpful, because that marker can be usedCancer26-Adamimage as a way to follow success of treatment. However, the presence of a marker does not make the diagnosis, since many other tissues may express the same protein. Nor does the absence of a marker allow us to say that there is no tumor.

Treatment

Standard allopathic treatment of colorectal cancer is primarily surgical, if the tumor can in fact be removed surgically. In more recent years, these tumors have been removed laparoscopically, with good results and much less surgical morbidity – i.e. fewer side effects after surgery, less time spent in hospital, faster resumption of normal bowel function.[11]  Survival after “curative” surgical resection is about 50-60% at 5 years after treatment.[12]

Chemotherapy is generally not recommended, until evidence of recurrence is found – i.e. when the cancer returns. Unfortunately, there is widespread micrometastasis which occurs early in the course of any given cancer, so the potential for metastatic disease and recurrence of cancer is almost always high.[13]

When metastatic disease is found, the aim of surgery is no longer cure, but rather palliation, i.e. helping with relief of symptoms (e.g. intestinal obstruction) without expectation of cure. Under these circumstances, chemotherapy is generally recommended following surgery.

Many chemotherapy regimens have been studied. The most commonly used are FOLFOX (leucovorin, 5-FU and oxiplatin) and FOLFIRI (leucovorin, 5-FU and irinotecan). Addition of monoclonal antibodies further improved the statistical survival, increasing it to a median of about 2 years in those patients with metastatic disease at the time of diagnosis, in those patients with the right genetics.[14]

Is there a way to tell if chemotherapy will be successful? Is the pain worth the gain?

The side effects of conventional chemotherapy are well documented, and anticipated to occur in almost everyone who undergoes chemotherapy. Since the drugs generally work by disrupting rapidly dividing cells (presumably tumor cells), they also disrupt all rapidly dividing cells – in the bone marrow, the mucus membranes of the mouth and intestinal tract, the hair, the skin. Thus the well-known “side effects” of decreased white blood cell count, hair loss, mouth ulcers, diarrhea. Some of the drugs even result in irreversible heart failure (anthracyclines) or respiratory failure (bleomycin) or kidney failure (cisplatin, methotrexate) or neurologic toxicity (cisplatin, vinca alkaloids, taxanes) – sometimes long after the chemotherapy has stopped.

Less conventional chemotherapy has found ways to target the tumor cells without simultaneously targeting all rapidly dividing cells, by utilizing a characteristic of cancer cells which is present to a much lesser degree on non-cancerous cells. Because of their peculiar metabolism, cancer cells are covered with insulin and insulin-like growth factor receptors, so that they can take more than their fair share of glucose from the blood. Donato Perez Garcia, MD discovered in the early 1930s that giving insulin to a patient would allow more antibiotic drugs to penetrate the blood brain barrier. In subsequent years he discovered that the same technique would allow more chemotherapeutic drug to enter cancer cells, thus opening the way for chemotherapeutic treatments that do not risk the destruction of the entire organism. This treatment is called “insulin potentiation therapy”, also known as “low dose chemotherapy” to kill the cancer cells without simultaneously killing all the body’s rapidly-dividing cells. This therapy uses about 1/10 the standard dose of chemotherapeutic agent, driving the chemotherapy into the cells by means of insulin, so that you get the full effect of treatment with very few, if any, side effects. Most patients feel well enough to go out to lunch or dinner after their treatments. 

How do we know which chemo agents to use?

Conventional oncology uses specific drugs for treatment of specific cancers. These drugs are chosen largely on the basis of anecdotal evidence, or through a clinical trial which shows some survival benefit for one regimen over another. Conventional oncology does not generally use the genetic markers of tumor susceptibility (either solid tumors or circulating tumor cells) to determine the choice of therapy. We used to choose antibiotic therapy by that method – what generally works in most people for infection in a specific location – but have for many years now chosen antibiotics based on the susceptibility of the bacterial population in the specific individual who is infected.

At the Arizona Center for Advanced Medicine we use a test for circulating tumor cells[15] in the peripheral blood, called the RGCC™ test.

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Refer to the specific paragraph about 2/3 down the page of the article: “RGCC test for circulating tumor cell count, chemosensitivity and sensitivity to alternative treatments – it is now possible to detect circulating tumor cells (CTC) in the blood stream. A blood sample is sent to a genetic laboratory in Greece. If CTCs are found, they can be grown in tissue culture, and tested against a multitude of chemotherapeutic agents as well as “alternatives” and botanicals, to see which substances have the highest kill rate in tissue culture. This is not a 100% guarantee that it will work on the original tumor, but it’s a pretty good indication – and far better than anything we have available in the United States.” Click here >> http://goo.gl/AZrXP .

This test is helpful for determining both susceptibility of solid tumors (if we have a piece of the tumor to test), and because we know that tumors have a very high potential for metastasizing or spreading, by shedding tumor cells into the circulation. The circulating tumor cells will not always give us any good indication as to their source (i.e. the location or organ of the primary tumor). They will give us an excellent indication as to their sensitivity to standard chemotherapeutic agents and to more natural cancer-fighting compounds.

There is much in the scientific literature to support this approach to therapy.

We tend to think about “cancer” as a single disease, and “colon cancer” as a single entity. We think that all colon cancer cells are exactly the same, and have the same altered genetics which allowed them to escape from physiologic control in the first place. However, it is quite clear from reading the literature that not all tumors are created equal, and not all cells originating in the same tumor have the same genetic expression[17], [16].

K-Ras is a gene associated with GI cancers in a high proportion of patients. K-Ras mutations are found in up to 65–100% of pancreatic carcinomas[18], 3 36% of colorectal cancers, and 20% of non-small cell lung cancers.[19]  The EGFR (epidermal growth factor receptor) is a transmembrane tyrosine kinase that signals through at least 2 parallel intracellular pathways to regulate cellular proliferation and survival. Stimulation of the EGFR receptor results in activation of the RAS gene, resulting in independent function of this gene, and cell proliferation (i.e. neoplastic growth, or cancer).[20]

  • VEGF (vascular endothelial growth factor) promotes angiogenesis (growth of new blood vessels) in response to various conditions: hypoxia, mutant K-Ras, mutant p53 gene, TGF-β.
  • TGF-β regulates proliferation, apoptosis, differentiation and migration of cells.
  • EGFR targeted molecules, cetuximab and panitumumab, have been shown to increase disease-free survival, when given in combination with standard chemotherapy protocols (particularly FOLFIRI AND FOLFOX).[21] Patients with mutant K-Ras did not benefit from this treatment, but patients with wild-type K-Ras benefited significantly.

EGFR targeted molecules, cetuximab and panitumumab, have been shown to increase disease-free survival, when given in combination with standard chemotherapy protocols (particularly FOLFIRI AND FOLFOX).[1] Patients with mutant K-Ras did not benefit from this treatment, but patients with wild-type K-Ras benefited significantly.

The recommendation of the author is to ascertain the K-Ras status prior to initiating treatment with these monoclonal antibodies. The author concludes:

“We are entering an era of personalized medicine in cancer therapy where treatment is tailored to the individual. The predictive value of K-Ras mutations in the treatment of mCRC is very useful to clinicians and patients in terms of decision-making, avoiding toxicities, and decreasing financial burden.”

than utilizing their individual tumor genetics in order to choose an appropriate treatment.[22]

At the Arizona Center for Advanced Medicine, we make full use of all the diagnostic modalities available to us – pathology, radiology, tumor markers, circulating tumor cell analysis – to determine the best individualized treatment for each patient.

How about “alternative” or “natural” therapies?

We use the RGCC™ test again, to determine which particular therapies may be the most helpful. Many things have been used for treatment of cancer over the millennia, in many different ethnic

variations. We use many of them to this day, generally as adjunctive therapies, to improve our treatment results.

Therapy includes not only pharmaceuticals and botanicals, but also (and even more importantly) a focus on prevention of further damage, and repair to the systems which are already damaged or deficient.

The National Cancer Institute’s website states: “Colorectal cancer prevention is a clinical imperative, and a key part of prevention involves the search for drugs that can safely and effectively block or reverse colorectal cancer development.” We certainly agree with the prevention part of the statement. However, it is important to realize that prevention begins LONG before drugs are necessary to control inflammation.

Prevention starts with what goes in to the gut. And prevention can be initiated at any time. Just because you already have colon cancer does not mean it’s too late. Today can be indeed the first day of the rest of your life.

Anti-inflammatory drugs are known to reduce the incidence of GI cancers[23]. However, these Cox-2 inhibitors are also associated with increased cardiovascular risk, so it would appear that drug therapy may not be the best answer.

Adherence to the Mediterranean diet may be the best preventive measure we could possibly take.[24],[25] This nutritional program emphasizes fresh fruits and vegetables, whole grains, and olive oil, with relatively restricted intake of red meats and other animal proteins.

Sugars and starches tend to be highly inflammatory foods, and should be eaten only occasionally, if we wish to avoid inflammation in the gut. Foods to which the individual is allergic or sensitive also are inflammatory. We frequently hear the statement: “My child used to be allergic to milk, but outgrew the allergy.” Of course, the parents do not necessarily make the connection between “growing out of the food allergy” and the development of asthma or symptoms of ADHD, which may be simply deeper more serious manifestations of the original sensitivity.

Fruits and vegetables contain nutrients which our bodies need, and are seldom inflammatory. Red meats are considered “hot” in Chinese medicine, and are more inflammatory than poultry or fish.

Probiotics will help to restore the normal gut flora which antibiotics have often destroyed.  In addition, they reduce inflammation in the gut, and sometimes even help to potentiate certain forms of chemotherapy.[26]

Alternative therapies to modulate the immune system, decrease excessive cell growth, and kill cancer cells

Many natural and “alternative” (i.e. non-chemotherapeutic) treatments are used.

Resveratrol, a compound isolated from the skin of red grapes, which is reported to decrease the excessive growth of colon cancer cells, but is also reported to increase resistance to the chemo drug taxol. [27],[28],[29],[30]

Vitamin D [31],[32] - appears to have protective activity against colo-rectal carcinoma. We know that Vitamin D can induce cell differentiation (i.e. help cells grow up) and apoptosis (i.e. help cells die when they are damaged), as well as inhibiting excessive cell division, new blood vessel formation, and spread of tumor cells. There are vitamin D receptors in the colon and rectum.

Citrus aurantium (Sour orange) [33]

Vitamin A [34],[35]

Curcumin 26,[36],[37],[38],[39]

Medicinal mushrooms – there is extensive literature for all these, I have included only a small sample.

Vitamin C- has a long an honorable history of being healthy for the body in many ways, cancer among them[63],[64]. Dr. Linus Pauling was the initial proponent of the use of high doses of Vitamin C to maintain health. Vitamin C is both an anti-oxidant and a pro-oxidant, depending on the dose. When we use it to treat cancer, we use it as a pro-oxidant in high doses intravenously.[65],[66],[67]

Mistletoe – Iscador – extracts of the mistletoe plant have been used for centuries in treatment of cancer. Their mechanisms of action are beginning to be elucidated by the scientific community. Iscador has a modulating effect on natural killer cells[68], and has benefit along with chemotherapy to patients with pancreatic  and other forms of cancer.[69],[70],[71]

Poly-MVA – a supplement first patented in 1991, using a lipoic acid-palladium complex, together with other specific vitamins and nutrients. It has a remarkable anti-oxidant effect, and is able to restore function to mitochondria which have been damaged by oxidative stress, thus restoring cellular function to normal cells.[72],[73] In addition, once cancerous cell mitochondria start to function normally, they suddenly are able to use oxygen for metabolism, so either the mitochondrial byproducts kill the anaerobic (cancer) cells, or the cell’s normal function is restored. Either way, the supplement helps cancer patients go into remission, with practically no unwanted side effects. This supplement can be given orally or intravenously. An excellent description of the product, and its use in prostate cancer, can be read on the Poly-MVA website.

And, in the end, the filters have to be cleaned up before the cancer can be healed.

Call us at 480-240-2600 for further information about treatment of your cancer, using nutritional therapy, supplements, body work, mind work, integrative cancer treatments and low dose chemotherapy. Our doctors offer a free 15-minute consultation, so that you can determine whether this is the best place for your treatment.

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See much more information on the Arizona center for Advanced Medicine Website Resource Library, click here >> http://goo.gl/p4qbh .

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References:

[1] National Cancer Institute, http://www.cancer.gov/cancertopics/cancer-advances-in-focus/colorectal downloaded June 12, 2010.

[2] A Ekbom, C Helmick. Ulcerative colitis and colorectal cancer. A population-based study. NEJM 18; 323:1228-1233 (November 1, 1990).

[3] TsunozakiH, YoshinagaK et al. Cyclooxygenase-2 Overexpression in Colorectal Cancer is Associated with Non-polypoid Growth. Japanese Journal of Clinical Oncology 32:167-171 (2002).

[4] Feik E, Baierl A. Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control. 2010 Jan;21(1):91-7.

[5] Ma, Jing, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. JNCI, Vol. 91, April 7, 1999, pp. 620-25

[6] Hirayama K, Baranczewski P et al.  Effects of human intestinal flora on mutagenicity of and DNA adduct formation from food and environmental mutagens . Carcinogenesis, Vol. 21, No. 11, 2105-2111, November 2000. © 2000.

[7] Lynch HT, de la Chapelle A. Hereditary Colorectal Cancer. NEJM 10;348:919-932.

[8] Toden S, BirdAR et al.High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch. Carcinogenesis. 2007 Nov;28(11):2355-62.

[9] Yi SW, Sull JW et al. Alcohol consumption and digestive cancer mortality in Koreans: the Kangwha Cohort Study. J Epidemiol. 2010 May 5;20(3):204-11.

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[11] Lacy A, Garcia J et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial.  Lancet. 2002 Jun 29;359(9325):2224-9.

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[14] Saif MW. K-Ras mutations in colorectal cancer: A Practice Changing Discovery. Clinical Advances in Hematology & Oncology Volume 7, Issue 1 January 2009.

[15] Cristofanilli M, Budd T et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer. NEJM 351;824-26.

[16] Molnar B, Ladanyi A et al. Circulating Tumor Cell Clusters in the Peripheral Blood of Colorectal Cancer Patients. Clinical Cancer Research  (December 2001); 7: 4080-85.

[17] Cristofanilli M, Budd T et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer. NEJM 351;824-26.

[18] Levi S, Urbano-Ispizua A, Gill R. Multiple K-Ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res. 1991;51:3497-3502

[19] Raponi M, Winkler H, Dracopoli NC. K-RAS mutations predict response to EGFR inhibitors. Curr Opin Pharmacol. 20078;8:413-418.

[20] Saif MW. K-Ras mutations in colorectal cancer: A Practice Changing Discovery. Clinical Advances in Hematology & Oncology Volume 7, Issue 1 January 2009.

[21] ibid

[22] American Society of Clinical Oncology Technology Assessment: Chemotherapy Sensitivity and Resistance Assays. Downloaded June 12, 2010. Originally published in J Clin Oncology 22;17 (September 1), 2004: pp. 3631-3638.

[23] Arber N. Cyclooxygenase-2 Inhibitors in Colorectal Cancer Prevention. Cancer Epidemiology, Biomarkers & Prevention August 2008 17; 1852. doi: 10.1158/1055-9965.EPI-08-0167.

[24] Mantzoros CS, Williams CJ et al. Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. American Journal of Clinical Nutrition, Vol. 84, No. 2, 328-335, August 2006.

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[26] Baldwin C, Millette M et al.  Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis. Nutr Cancer. 2010 Apr;62(3):371-8.

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[28] Mao QQ, Bai Y et al. Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines. Mol Nutr Food Res. 2010 Jun 2.

[29] Vanamala J, Reddivari L et al. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 2010 May 26;10(1):238.

[30] Matić I, Zižak Z et al. Cytotoxic Effect of Wine Polyphenolic Extracts and Resveratrol Against Human Carcinoma Cells and Normal Peripheral Blood Mononuclear Cells. J Med Food. 2010 May 18.

[31] Krishnan AV, Trump DL et al. The role of vitamin D in cancer prevention and treatment. Endocrinol Metab Clin North Am. 2010 Jun;39(2):401-18.

[32] Takahashi R, Mizoue T et al. Circulating vitamin D and colorectal adenomas in Japanese men. Cancer Sci. 2010 Mar 23.

[33] Jayaprakasha GK, Jadegoud Y et al. Bioactive compounds from sour orange inhibit colon cancer cell proliferation and induce cell cycle arrest. J Agric Food Chem. 2010 Jan 13;58(1):180-6.

[34] Farah IO, Trimble Q et al. Retinoids and citral modulated cell viability, metabolic stability, cell cycle progression and distribution in the a549 lung carcinoma cell line – biomed 2010. Biomed Sci Instrum. 2010;46:410-21.

[35] Kikuchi H, Kuribayashi F et al. Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells. Biochem Biophys Res Commun. 2010 Apr 23;395(1):61-5.

[36] Suphim B, Prawan A et al. Redox Modulation and Human Bile Duct Cancer Inhibition by Curcumin. Food Chem Toxicol. 2010 May 24.

[37] Ide H, Tokiwa S et al. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate. 2010 Jul 1;70(10):1127-33.

[38] Watson JL, Hill R et al. Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Cancer Lett. 2010 May 14.

[39] Hilchie AL, Furlong SJ et al. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria.  Nutr Cancer. 2010 Apr;62(3):379-89.

[40] Gonzaga ML, Bezerra DP et al.  In vivo growth-inhibition of Sarcoma 180 by an alpha-(1–>4)-glucan-beta-(1–>6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. J Nat Med. 2009 Jan;63(1):32-40.

[41] Itoh H, Ito H et al.  Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. Oncol Rep. 2008 Dec;20(6):1359-61.

[42] Firenzuoli F, Gori L et al. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

[43] Angeli JP, Ribeiro LR et al.  Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes. Cell Biol Toxicol. 2006 Jul;22(4):285-91.

[44] Wan JM, Sit WH et al. Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells. Chin Med. 2010 Apr 27;5:16.

[45] Wan JM, Sit WH et al. Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol. 2008 Mar;32(3):689-99.

[46] Jiménez-Medina E, Berruguilla E et al. The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer. 2008 Mar 24;8:78.

[47] Bisen PS, Baghel RK et al. Lentinus edodes: A Macrofungus with Pharmacological Activities. Curr Med Chem. 2010 May 24.

[48] Kawanishi T, Ikeda-Dantsuji Y et al. Effects of two basidiomycete species on interleukin 1 and interleukin 2 production by macrophage and T cell lines. Immunobiology. 2010 Jul;215(7):516-20.

[49] Yu S, Weaver V et al. The effects of whole mushrooms during inflammation. BMC Immunol. 2009 Feb 20;10:12.

[50] Jedinak A, Sliva D. Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. Int J Oncol. 2008 Dec;33(6):1307-13.

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[56] Weng CJ, Chau CF et al. Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models. J Agric Food Chem. 2009 Jun 10;57(11):5049-57.

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[58] Kim HG, Song H et al. Cordyceps pruinosa extracts induce apoptosis of HeLa cells by a caspase dependent pathway. J Ethnopharmacol. 2010 Mar 24;128(2):342-51.

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[62] Zhu T, Guo J et al. Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer. 2007 Feb 26;96(4):583-90.

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[64] Miranda CL, Reed RL et al. Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chem Res Toxicol. 2009 May;22(5):863-74.

[65]Ullah MF, Khan HY et al. The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer. Cancer Chemother Pharmacol. 2010 Mar 6.

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[67] Chen Q, Espey MG et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008 August 12; 105(32): 11105–11109.

[68] Braedel-Ruoff S. Immunomodulatory effects of Viscum album extracts on natural killer cells: review of clinical trials. Forsch Komplementmed. 2010;17(2):63-73.

[69] Matthes H, Friedel WE et al. Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Curr Mol Med. 2010 Jun;10(4):430-9.

[70] Augustin M, Bock PR et al. Safety and efficacy of the long-term adjuvant treatment of primary intermediate- to high-risk malignant melanoma (UICC/AJCC stage II and III) with a standardized fermented European mistletoe (Viscum album L.) extract. Results from a multicenter, comparative, epidemiological cohort study in Germany and Switzerland. Arzneimittelforschung. 2005;55(1):38-49.

[71] Friedel WE, Matthes H et al. Systematic evaluation of the clinical effects of supportive mistletoe treatment within chemo- and/or radiotherapy protocols and long-term mistletoe application in nonmetastatic colorectal carcinoma: multicenter, controlled, observational cohort study. J Soc Integr Oncol. 2009 Fall;7(4):137-45.

[72] Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV. Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats. Food Chem Toxicol. 2010 Jul;48(7):1858-62. doi: 10.1016/j.fct.2010.04.022.

[73] Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV. Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats. Food Chem Toxicol. 2009 Aug;47(8):2124-8. doi: 10.1016/j.fct.2009.05.032.

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View the entire Arizona Center for Advanced Medicine Cancer Series articles, click here >> http://goo.gl/VFLmD.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

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Natural cancer treatment – par excellence! Cancer Series #25. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600

Cancer25Header

Agaricus brasiliensis (aka blazei) murill – Natural cancer treatment par excellence.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

History – Agaricus brasiliensis murill (ABM) is native to Brazil, where it is known as Cogumelo do sol. In Japan it is called Himematsutake, Cancer25-fig1Agarikusutake or Kawarihiratake and in China Ji Song Rong.[1]It was discovered in 1960 by a Japanese researcher, Takatoshi Furumoto and sent to Japan for investigation.[2] It has been studied as a functional food and medicinal product. Its use as a medicinal product was first described around the 4th century A.D. as a treatment for malignant ulcers of the larynx.[3] In modern times it is used as anti-oxidant[4], anti-diabetic[5], cholesterol-lowering[6], anti-cancer[7],[8], immunomodulatory[9], anti-allergic[10], kidney protective[11], and anti-microbial agent[12].

The anti-tumor effects, more specifically, include reactive oxygen species inducer[1], anti-mitotic[2], angiogenesis inhibitor[3], topoisomerase inhibitor[4], leading to apoptosis[5], and eventually checking cancer proliferation.

Extracts of ABM appear to exert a significant effect on the immune system.[6] They activate white blood cells, macrophages, neutrophils and lymphocytes  – cells which are crucial in recognition and destruction of circulating tumor cells. These are all part of our general defense system – the guards at the gate, which we call the innate immune system.

The innate immune system is present at birth. It responds to foreign invaders – mainly microbial – in a relatively non-specific fashion. It does not make specific antibodies. Rather it recognizes certain patterns present in bacteria, leading the macrophages to surround and destroy the bacteria. The innate immune system is also crucial in the recognition of abnormal cells – cancer cells – which it normally engulfs and destroys.Once a virus or bacterium penetrates the skin (or the mucus membranes) a local infection results, causing tissue damage which, in turn, causes the tissue macrophages to call for help by secreting specific cytokines. These cytokines call for more immune cells which then surround the pathogens and destroy them.

The Complement cascade is activated, manufacturing C3a and C5a to attract yet more white cells to the area, along with fluid from the capillaries. The cytokines, when they reach the liver, cause the manufacture of acute phase proteins (sometimes called heat shock protein). Body temperature is raised, and NK (Natural Killer) cells are activated to destroy virus-infected cells. Interferon alpha and beta are secreted to make nearby cells more resistant to viral infection.

Cancer25-fig2

For all that Agaricus brasiliensis has so many health effects, it is a fastidious and demanding species, and must be picked within a few hours of the fruiting body maturing. The glucan content increases as the fruiting body matures, so the time of harvest is of great importance, and explains (in part) the cost of the best supplements of the mushroom.[1]

The quality of the mushrooms themselves is another important consideration. In 2006 the Japanese ministry of health decided to recall Cancer25-mushroomsproducts containing Agaricus brasiliensis because of a suspicion that the mushroom could induce the development of liver failure and cancer.[2] After extensive testing, it was determined that those mushrooms which grew in polluted urban areas of China did indeed induce liver cancer in mice[3], but that the mushrooms grown in non-polluted areas had no such effect. In fact, the agaricus species that were tested had such high mercury concentrations, one wonders whether that species is attempting to protect the environment by absorbing the toxic mercury.

The quantity of beta-d-glucan in a mushroom product depends on the quality and grade of the mushroom. Most ABM mushrooms grown outside of Brazil range from 3 to 4 %. In its natural environment, the ABM mushroom can contain up to 7% d-glucan on average. Ultra Gold quality ranges above 4.8%. Companies

selling ABM mushrooms claiming to contain 45% or more beta-D-Glucan are selling a manufactured standardized product, where Beta-D-Glucan has been added because 45% in nature does not exist.

Both alpha and beta glucans enhance the immune system, both have anti-tumor activity, and both appear in larger quantities as the fruiting body matures.[1]

(Click on the image to make larger.)

Cancer25-group

Hear from an Arizona Center for Advanced Medicine cancer patient below…

Sources:

[1] F. Firenzuoli, L. Gori, and G. Lombardo. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

[2] Firenzuoli F, Gori L, Lombardo G. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 Mar;5(1):3-15. doi: 10.1093/ecam/nem007.

[3] RamoutsakiIA, Helidonis ES, et al. Therapeutic methods for otolaryngological problems during the bzantine period.  Ann Otol Rhinol Laryngol 2002;111:553–7.

[4] Oliveira OM, BrunettiIL et al.Antioxidant activity of Agaricus blazei. Fitoterapia. 2007 Apr;78(3):263-4.

[5] Hsu CH, Chou P et al. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102.

[6] Kweon MH, Park YI et al. Lowering effects in plasma cholesterol and body weight by mycelial extracts of two mushrooms: Agaricus blazai and Lentinus edodes. Korean Journal of Microbiology and Biotechnology 2002;30(4):402-9.

[7] Fan MJ, Chung JG, et al. Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway. In Vivo. 2011 May-Jun;25(3):355-66.

[8] Pinto AV, Kaneno R et al. Polysaccharide fraction of Agaricus brasiliensis avoids tumor-induced IL-10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma. Cell Immunol. 2009;256(1-2):27-38. doi: 10.1016/j.cellimm.2009.01.002.

[9] TangNY, Chung JG et al. Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice. In Vivo. 2009 Sep-Oct;23(5):761-6.

[10] Ellertsen LK, Hetland G. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clin Mol Allergy. 2009; 7: 6. doi:  10.1186/1476-7961-7-6  

[11] Dalla Santa HS, Soccol CR et al. Kidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (=Agaricus blazei, Agaricus subrufescens) Produced by Solid State Cultivation. OnLine Journal of Biological Sciences 9 (1): 21-28, 2009

[12] Valadares DG, Coelho EA et al. Prophylactic or therapeutic administration of Agaricus blazei murill is effective in treatment of murine visceral leishmaniasis.Exp Parasitol. 2012 Jul 20.

[13] Bernardshaw S, Johnson E et al. Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo. APMIS. 2007 Jun;115(6):719-25.

[14] Jiang SM, Xiao ZM, Xu ZH. Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor. World J Gastroenterol. 1999 Oct;5(5):404-407.

[15] Niu Y.C. Wu XX et al. A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo. Oncol Rep. 2009 Jan;21(1):145-52.

[16] GrynbergNF, Braz-Filho R, et al. DNA topoisomerase inhibitors: biflavonoids from Ouratea species. Braz J Med Biol Res 2002; 35: 819-822.

[17] Kim MO, Kim GY et al. Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells. Evid Based Complement Alternat Med. 2011:838172. doi: 10.1093/ecam/nep176.

[18] Huang TT, Lai HC et al. The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1β Production and Activates the NLRP3 Inflammasome in Human Macrophages.PLoS One. 2012; 7(7):e41383. Epub 2012 Jul 23.

[19] Camelini CM, Tavares LA et al. Structural characterization of beta-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Lett. 2005 Sep;27(17):1295-9.

[20] Mukai H, Katsumata N et al. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol. 2006 Dec;36(12):808-10.

[21] Chen XH, Qui GZ et al. Analysis of several heavy metals in wild edible mushrooms from regions of China. Bull Environ Contam Toxicol. 2009 Aug;83(2):280-5. doi: 10.1007/s00128-009-9767-8.

[22] Camelini CM, Tavares LA et al. Structural characterization of beta-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Lett. 2005 Sep;27(17):1295-9.

[23] F. Firenzuoli, L. Gori, and G. Lombardo. The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15.

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Integrative Cancer Care. Cancer Series #22. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer22

The Exclusive Cancer Series #22 – Integrative Cancer Care.

Important information cancer patients and their families should know.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Chemo, surgery, radiation – this is the mantra of current recommendations for cancer therapy. Treatment options on the website of the Mayo Cancer18-BestAnswerLogoClinic, “the most innovative, progressive care anywhere” are the following: bone marrow transplantation, chemotherapy, radiation therapy and radio frequency ablation.[1]

And yet… the incidence of cancer is projected to rise 75% by the year 2030.[2] What is wrong with this picture?

Insulin potentiation chemotherapy, low dose

The National Cancer Institute describes side effects of conventional chemotherapy on its website.[3]Cancer18-vomit

Some common side effects from chemotherapy are fatigue, nausea, vomiting, decreased blood cell counts, hair loss, mouth sores, and pain… Sometimes, chemotherapy causes long-term side effects that do not go away. These may include damage to your heart, lungs, nerves, kidneys, or reproductive organs. Some types of chemotherapy may cause a second cancer years later.

The website does not mention death from destruction of the immune system and systemic infection.

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View an entire article on Insulin potentiation chemotherapy at our website, click here >> http://goo.gl/gaXOZ .

Chemotherapy is actually pretty effective for a few cancers.4 Greater than 10% survival can be attributed to cytotoxic chemotherapy in the following cancers: cervix 12%, ovary 8.7%, testicle 41.8%, Non-Hodgkins Lymphoma 10.8%, Hodgkins Lymphoma 35.8%. Breast cancer gets only 1.5% survival increase from chemotherapy, colon cancer 1.8%, brain cancer 4.9%.

Why are we so quick to put conventional chemotherapy first on the list for cancer treatment? Graeme Morgan, an Australian radiation oncologist, writes: “For most patients, the use of cytotoxic chemotherapy is for the palliation of symptoms and to improve quality of life.” However, Dr. Morgan concludes: ““The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.” [1]

If conventional chemotherapy were less toxic, it might be worth it. But for a 2.5% benefit? It is hard to discern the advantages.

Most people are not aware that there is a gentler form of chemotherapy, known as Insulin Potentiation Therapy, low dose.[2],[3] This therapy is just as effective as standard chemo, without all the painful and sometimes lethal side effects. Insulin is used to lower the blood sugar, resulting in relatively increased starvation of cancer cells which require more sugar than normal body cells. Once the blood sugar is sufficiently low, sugar is given intravenously, along with a small dose of chemo (about 10-15% the usual dose). The chemo is sucked into the cells, along with the sugar, and concentrates in cancer cells because they are so much more avid for sugar than normal cells.[4],[5]

With IPT, the incidence of so-called side effects is markedly decreased. Most of our patients drive themselves home from treatment. They may report a little fatigue on the day of treatment. Seldom do they lose any hair at all, and they hardly ever drop their white blood cell counts. They are able to lead normal lives during the course of their IPT therapy.

View the FREE video below describing I.P.T. therapy at Arizona Center for Advanced Medicine…

If our therapies are so effective, why is the incidence of cancer projected to rise so dramatically? And why are the therapies in fact not effective Cancer18-Fig1for every form of cancer?

Our bodies are full of toxins – chemicals from our foods and from the air we breathe, artificial colorings and flavorings, artificial sweeteners (like chlorinated hydrocarbons, or pesticides), high levels of sugar with consequent high levels of insulin, or even frank diabetes. So it is not surprising that mutations can occur. That is the essence of cancer. The cells mutate to a lower state of being, one where they are only concerned with growth, and not with the good of the entire organism.

Insulin Potentiation Therapy – even low dose – is NOT ENOUGH to treat cancer, any more than chemotherapy by itself is a sufficient treatment. For truly integrative cancer therapy, many different modalities are brought into play.

It is helpful to know which chemotherapy to use – which actually kills your cancer cells, not just which has been studied and had a good effect on 30% or 50% of people in whom it was tried. It is equally helpful to know which complementary – botanical and supplemental – therapies could be therapeutic.

Chemosensitivity testing is available – but not in these United States, unfortunately.  We use a laboratory in Greece, run by an oncologist, to determine which drugs and which supplements to use for the greatest effect. 

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View more information on the Greek RESEARCH GENETIC CANCER CENTRE LTD methods, click here >> cancer18-Fig2http://goo.gl/hEh1F , and scroll about half way down the page.

  • We use standard chemotherapeutic agents – and sometimes even standard combinations as recommended in the current oncology literature.[1]
  • We use botanical remedies like Iscador[2], and supplements like high dose Vitamin C[3] (but not if bortezomib is part of the regimen chosen[4], lipoic acid[5], glutathione[6] and many others, to restore the function of natural killer cells, and to bring the body back to a state where it can defend itself against the foreign cancer cell invaders.
  • We teach our patients the basics of a healthy diet – encouraging mainly plant-based foods[7] in  the early phases.
  • We test for nutrient deficiencies, and administer nutrient IV therapies to replenish the body’s stores.Cancer18-Fig3
  • We work with our patients to help them dismantle barriers to healing – old dogma, old conflicts, old beliefs, old injuries, physical or emotional, which they have been unable to see or unwilling to give up.

View more information on the Arizona Center for Advanced Medicine website…

iconMoreInfo

View more information on basics of a healthy diet, click here >> http://goo.gl/HrAjT .

View more information on nutrient IV therapies, click here >> http://goo.gl/2usMN .

View more information to dismantle barriers to healing, old beliefs, click here >> http://goo.gl/nUdhX .

Cancer18-beliefLEFT

As with any medical therapy, it is unwise to throw out everything, because each form of therapy has its use. Chemotherapy does indeed kill many cancer cells. High dose Vitamin C kills many others. Anti-inflammatory supplements and spices help to restore balance to the immune system. Cancer18-textgraphicNutrients help to sustain the body in its battle. And release of old stuff helps to restore the soul to a place of gratitude and love.

Every modality plays a part in our therapies. We are honored to share the journey with our patients. We would prefer to share the journey earlier in its course rather than later, when the immune system is already gone, and the body is in desperate straits.

Standard chemotherapy is like a bomb exploding, creating collateral damage to the organism.

Insulin Potentiation Therapy, when combined with Integrative and Functional Medicine Therapy, is a lifeline to help restore physical function and enable the body to heal.

Hear from an actual Cancer patient in the video below…

iconMoreInfo

For more information about our integrative cancer care, please visit the website, click here >> http://goo.gl/oMoAu.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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Sources:

[1] Downloaded 12/2/2012 from http://www.mayoclinic.org/cancer-treatment/diseases.html

[2] Bray F, Jemal A, Forman D et al. Global cancer transitions according to the Human Development Index (2008—2030): a population-based study. The Lancet Oncology, Volume 13, Issue 8, Pages 790 – 801, August 2012

[3] Downloaded 12/2/2012 from http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you/page5

[4] Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.

[5] http://www.arizonaadvancedmedicine.com/therapies/IPT_therapy.html

[6] http://www.bestanswerforcancer.org/what-is-insulin-potentiation-therapy-low-dose-iptld/

[7] Raffaghello L, Safdie F, Longo VD et al. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15;9(22):4474-6.

[8] Lee DH, Raffaghello L, Longo VD et al. Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Sci Transl Med 7 March 2012: Vol. 4, Issue 124, p. 124 – 27

[9] Chu E, DeVita VT. Physicians’ Cancer Chemotherapy Drug Manual (updated every year). © Jones & Bartlett Learning, LLC. ISBN 978-1-4496-4683-7.

[10] Strüh CM, Jäger S, Martin SF et al. A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells. Phytother Res. 2012 Feb 8. doi: 10.1002/ptr.4604.

[11] Frei B, Lawson S. Vitamin C and Cancer Revisited. PNAS August 12, 2008 vol. 105 no. 32

[12] Perrone G, Hideshima T, Anderson KC et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia. 2009 Sep;23(9):1679-86.

[13] Zachar Z, Marecek J, Bingham PM et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

[14] Singh S, KhanAR, GuptaAK. Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol. 2012;9(4):303-16.

[15] Campbell TC, Campbell II TM. The China Study. © 2006, BenBella Books. ISBN 978-1932100-66-2

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Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Oral cancer – Early detection test now available. Cancer Series #21. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. call 480-240-2600.

Cancer21

The Exclusive Cancer Series #21. Oral cancer – Early detection test now available.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

It is estimated by the National Institutes of Health (NIH)[1] that 12,770 people (three times more men than women) will be diagnosed with tongue cancer, and that about 2000 of them will die of their disease. About 8% of those afflicted are under the age of 45. 40% are over the age of 65.Cancer21-FdnSymbol

The tongue is not the only organ in the mouth – just the most visible. 40% of oral cancers are found in the tongue; the lips and floor of the mouth account for another 35%.[2] It is estimated that 40,250 people (again three times more men than women) will be diagnosed with cancer of the oral cavity and throat, and that about 7800 of them will die of their disease. The lips and the floor of the mouth are the next most frequent sites of disease.

Lifetime risk is about one in 100 – about the same incidence as autism. The incidence is increasing, with an 11% jump in 2007 alone.[3]

Three main causes of oral cancer are “smokeless” tobacco (snuff or chew), alcohol, and Human Papilloma Virus (HPV), presumably acquired through oral sexual intercourse. Non-smoking patients under the age of 50 are the fastest growing segment of the population in which oral cancer is diagnosed. Most of these cancers are found by dentists during the course of routine examination.Cancer21-oraldrawing

The NCI website states: “There is no standard or routine screening test for oral cancer.”[4]

Over half of oral cancers have already spread to the lymph nodes by the time they are seen and diagnosed. If found early, the 5 year survival is 80-90%. With spread to the lymph nodes, 5 year survival decreases to 45%.[5]

Any non-healing sore in the mouth or on the lips should prompt a visit to your dentist for examination. Your physician can also examine your mouth and tongue, but your dentist has the better tools to examine the entire oral cavity.

Screening tests have been developed. One commercially available test involves rinsing the mouth with a blue dye, then illuminating the oral cavity with a special light.[6] The following images were downloaded from the website of the company which makes the device.[7]

Cancer21-OralTongue

Cancer21-AdvancedAnother test involves using salivary markers both for diagnosis and for survival estimates.[1],[2] This test is also now available commercially[3] It is based on good research published in the peer-reviewed literature, although it has not yet been validated by multiple studies.

At the Arizona Center for Advanced Medicine we use every modality available to us to provide truly integrative care for our patients with cancer.

Please view these additional webpage’s provided by Arizona Center for Advanced Medicine with additional information on cancer treatment…

Nutrition is crucial – a low carbohydrate low animal protein diet appears to be the most successful for patients with a diagnosis of cancer.

View food nutrition articles on our website, click here >> http://goo.gl/byFUW and http://goo.gl/llq2C .

Supplementation of vital nutrients – we measure those nutrients (vitamins, mineral, fatty acids) and replace those which are functionally deficient in the individual patient. We don’t just look at population based numbers because everyone has different needs, and requires different amounts of the nutrients, based on their genetics. We use both oral and intravenous supplements to fill in the big nutritional potholes and provide the body with what it needs to heal.

View food Supplementation articles on our website, click here >> http://goo.gl/zA821 and http://goo.gl/dGrNC .

Chemo- and Botanical Sensitivity Testing to determine which drugs, supplements, botanicals and other therapies have the best kill rate of circulating tumor cells – those cells which are responsible for metastasis of the tumor (distant spread) and which will eventually lead to the patient’s death.

View article, for the section entitled The Cellular Genetics Test  scroll half way down this page, click here >> http://goo.gl/mST5W .

Integrative cancer treatments – using botanicals, supplements and specific nutrients which have been shown to be helpful both in prevention and in treatment of cancer.

View our Integrative Cancer Treatment article, click here >> http://goo.gl/6I38T .

Bioenergetic modalities – to help pinpoint and treat the root cause of the cancer, whether it be physical or emotional toxin, so that any blocks to healing may be removed, and true healing may occur.

View our website article on Energy Medicine, click here >> http://goo.gl/zrx2K .

Insulin potentiation therapy – chemotherapy at low dose, potentiated by insulin, to destroy the cancer cells without destroying the immune system, the intestinal tract, the blood, the hair… We choose drugs based not only on standard therapy, but also on the results of specific chemosensitivity testing of circulating tumor cells.

View our article on Insulin Potentiation Therapy (IPT), click here >>  http://goo.gl/mST5W .

View a video on IPT treatment at Arizona Center for Advanced Medicine below…

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g

Please view these additional webpage’s provided by Arizona Center for Advanced Medicine with additional information on these relative subjects…

Nutrition:

Food 201 – Is Organic Really Better? Cancer21-USDA

You can point to different studies that argue about the extra nutritional value of Dr. Marion Nestle, chairwoman of the department of nutrition, food studies and

View the entire Food 201 article, click here >> http://goo.gl/UkC6I .

FOOD 101 – Genetics, Addiction, and PoliticsCancer21-adboards

Nutrition decisions based largely on studies funded by the processed food industries gave birth Nutrition “experts” went with the flow and spread the message.

View the entire Nutrition article on our website, click here >> http://goo.gl/wWhVf .

Genetically Modified FoodGMOfilmCoverW

In addition to their potential to produce hard-to-detect allergies and nutritional problems, the scientists said that “The possibility of unexpected, accidental

View the entire website article on “Genetically Modified Food”, click here >> http://goo.gl/1eumZ .

Nutritional IV Therapies.Cancer21-chemo

Nutritional IV Therapies. IV therapy can be more effective than taking supplements orally for correcting intracellular nutrient deficits. The intravenous methods

View the entire website article “Nutritional IV Therapies”, click here >> http://goo.gl/dde02 .

Supplementation:

Safety Net I and II Supplements.Cancer21-Suppliments

You want supplements with the upmost potency and quality, but they can be expensive and time consuming to organize. I asked a master formulator to combine

View the entire Supplements article on our website, click here >> http://goo.gl/yfvhh .

Nutritional IV Therapies.Cancer21-IVnutrition

Nutritional IV Therapies. IV therapy can be more effective than taking supplements orally for correcting intracellular nutrient deficits. The intravenous methods

View the entire website article “Nutritional IV Therapies”, click here >> http://goo.gl/dde02 .

Chemosensitivity testing:

Colon Cancer.Cancer21-Intestines

Declare the one-size-fits-all approach (sometimes called “cookbook medicine”) obsolete and do chemo-sensitivity testing for each individual patient to determine …

View the entire article on our website, click here >> http://goo.gl/HaKrm .

Melanoma | Skin Cancer.Cancer21-Lady

The study questioned whether this might not be a useful way of determining chemosensitivity.[22] In other words, let’s custom design the chemotherapy to attack …

View the entire Melanoma article on our website, click here >> http://goo.gl/BQhV6 .

Insulin Potentiation Therapy for Cancer | IPT:

Insulin Potentiation Therapy for Cancer | IPTCancer21-MRI

He has developed a way of isolating circulating tumor cells from peripheral blood , growing them in cell culture, and testing them for chemosensitivity, as well as …

View the entire article on our website on IPT, click here >> http://goo.gl/3xSla .

Arizona Center for Advanced Medicine – Martha M. Grout, MD, MD(H)DrGroutW

IPT is a targeted, low dose chemotherapy combined with complementary therapies. IPT targets the delivery of specific drugs to the cancer cells, bypassing most …

View the entire article on our website, click here >> http://goo.gl/4u72p .

Pancreatic Cancer | Cancer of the Pancreas:Cancer21-AdamSketch

It is important to know what they may be sensitive to, and so immediately we test for chemosensitivity – which drugs will work best for you. If we are seeing you …

View the entire Pancreatic Cancer article on our website, click here >> http://goo.gl/NgMUr .

Cancer | Cancer Prevention:

Cancer | Cancer Prevention.Cancer21-Chart

The BioFocus Analysis is also a chemosensitivity test. Like all cells, tumor cells have a genetic makeup. Knowing that makeup tells us which treatments are …

View the entire Cancer and Cancer Prevention article on our website, click here >> http://goo.gl/CTxi1 .

Bioenergetic Modalities:

The Chiren.Cancer21-Chiren

Dr. Martha M. Grout of the Arizona Center for Advanced Medicine and Clinical Research in Scottsdale, Arizona, practices homeopathic medicine which

View the entire article on the Chiren, click here >> http://goo.gl/AKjep .

The Chiren™ – Delving Deep into the Nature of Life Itself · Erectile Dysfunction · Fish Oils and Oils, Fats and Trans Fats · A Public Relations Campaign on Oils

View the entire article on the Chiren, click here >> http://goo.gl/AKjep.

Energy Medicine | Bioenergetic Medicine:

Energy Medicine | Bioenergetic MedicineCancer21-Suppliments

Energy medicine works with our natural energy field to stimulate the body’s own healing mechanisms.

View the entire Energy medicine article on our website, click here >> http://goo.gl/Itu0w .

Body Burden and Chronic Disease and DetoxCancer21-YouTube

We reverse chronic illness with detoxification through chelation, colonics, nutrition, and bioenergetics to decrease the body burden of heavy metals. Dr. Martha

View the entire Body Burden and Chronic Disease and Detox article, click here >> http://goo.gl/Rj9YI .

View a complete library of article on the Arizona Center for Advanced Medicine website, click here >> http://goo.gl/8kEPI .

Sources:

[1] http://seer.cancer.gov/statfacts/html/tongue.html downloaded 11-19-12

[2] http://www.oralcancerfoundation.org/dental/screening.htm downloaded 11-19-12

[3] http://oralcancerfoundation.org/ downloaded 11-19-12

[4] http://www.cancer.gov/cancertopics/pdq/screening/oral/Patient/page3 downloaded 11-19-12

[5] http://oralcancerfoundation.org/ downloaded 11-19-12

[6] Epstein JB, Silverman S Jr, Epstein JD, et al. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol. 2008;44(6):615. http://www.ncbi.nlm.nih.gov/pubmed?term=17996486

[7] http://www.zila.com/40/VIZILITE%26REG%3B%20PLUS/ downloaded 11-19-12

[8] http://www.zila.com/40/VIZILITE%26REG%3B%20PLUS/ downloaded 11-19-12

[9] St JohnMA, Li Y, Wong DT et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug;130(8):929-35.

[10] Korostoff A, Reder L, Masood R, Sinha UK. The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 2011 Apr;47(4):282-7.

[11] http://www.advanced-lab.com/news/Newsletter_July2012.pdf downloaded 11-19-12

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

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Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Bladder Cancer – What caused it? Cancer Series #20. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer20

Cancer Series # 20 – Bladder Cancer – What caused it? Why me? Why now?

Bladder cancer is the fourth most common cause of cancer in men. There are well established guidelines for its treatment.[1] Nevertheless, the 5-year relative survival statistics are not good, once the cancer has spread beyond the superficial layers of the bladder.[2]LogoAmerCancerSoc

The American Cancer Society has an excellent web article about bladder cancer, describing the conventional medical understanding of its treatment.[3]

Causes of bladder cancer are multiple. As with any cancer, there is a predisposition for problems in that organ system (kidney/bladder). The cancer20-diagramkidneys are a major organ of excretion of many chemicals which are stored in the bladder while waiting to be expelled from the body through urination.

On top of the predisposition, there is an inciting factor (or several) which may include chronic infections, arsenic in drinking water, prior chemotherapy or radiation therapy, birth defects, deficiencies of detoxification enzymes (GST – glutathione-S-transferase – or NAT – n-acetyl transferase).

The industries carrying highest risks include the makers of rubber, leather, textiles, and paint products as well as printing companies. Other workers with an increased risk of developing bladder cancer include painters, machinists, printers, hairdressers (likely because of heavy exposure to hair dyes), and truck drivers (likely because of exposure to diesel fumes). Cigarette smoking and workplace exposures may act together to cause bladder cancer. Smokers who work with the cancer-causing chemicals noted above have an especially high risk of developing bladder cancer.[4]

Smokers are twice as likely to develop bladder cancer as non-smokers.cancer20-smoking

What we fail to recognize, in our allopathic Western medicine, is that cancer is the body’s ultimate cry for help in a situation of unresolved conflict.[5] The conflict may be purely physical – i.e. exposure to toxic chemicals. More often the physical is superimposed upon a psychological conflict – some kind of emotional shock and conflict – which generally occurs one to two years before the tumor manifests. This is not to say that the emotional shock is the cause of the tumor, but rather that the shock opens the door so that the tumor can progress.

At the Arizona Center for Advanced Medicine we use multiple modalities in the treatment of cancer.

When surgery and/or radiation therapy are indicated, we recommend it, and help our patients find the appropriate surgeon and/or radiation oncologist to perform the procedure.

We treat the cancer using Insulin Potentiation Therapy (IPT) – which allows us to use standard chemotherapeutic drugs at a MUCH lower dose than standard chemotherapy – so that we get the benefits of chemotherapy without most of the side effects.

View one of our patients having I.P.T. treatment below…

We test the chemotherapeutic agents to see which ones have the greatest kill rate for the individual patient’s circulating tumor cells (and original tumor cells, if a fresh specimen is available). Thus, we can use chemotherapy which actually works on the individual tumor, rather than chemo that has been tested in hundreds of patients and works on 30 or 50 or 75 percent of their tumors. We use combinations of drugs based on testing, whether they are standard combinations or not.

We re-test periodically, to make sure that we are still administering the appropriate agents, because cancer cells are infamous for Cancer20-killcellsmutating, changing their characteristics from generation to generation as the cells rapidly divide. Their DNA is notoriously not stable, so daughter cells may have very different characteristics from the parent cancer cell – which is already very different from the normal cells.

We also treat with supplements and botanicals which are known to have an effect on cancer cells and on the immune system. Medicines like artemisinin, mistletoe, genistein, naltrexone (in very low dose), modified citrus pectin and many others are known to stimulate cancer cell apoptosis (cellular suicide), decrease the formation of new blood vessels, stimulate our own natural killer cells, and decrease the likelihood of cancer cells metastasizing and setting up shop for new tumor formation.

We help our patients investigate the potential emotional shocks which may have been the trigger for the development of the cancer which brought them to us. We do not force the issue, but we do hold the light on the path.

And our success rate is measured in quality of life and resolution of conflict. The sooner we are able to treat, the better. Some have no recurrence of cancer. Others experience arrest of tumor growth. And some experience progression of the tumor. There are no guarantees of healing – any more than there are in conventional oncology. The only guarantee is that the treatment is much more gentle, does not often cause major side effects, and is administered in an atmosphere of caring – both from the staff at the Center and from the other patients.

Conventional oncology is beginning to realize that there is a connection between cancer treatment and the state of metabolism. A few researchers are looking in to the relationship between glucose uptake and cancer cell growth and chemotherapy treatment.[1],[2],[3] And the drug companies are starting to take an interest in the concept.[4]

Physiologically, all cancers are caused by an alteration in the metabolism of the cells which turn cancerous. Otto Warburg was awarded the Cancer20-DrWarbergNobel Prize for this discovery. The big question is: what causes the cells to so drastically change their metabolism? Is it environmental pollution? Is it infection by viruses, bacteria or fungi? Is it terrible eating habits? Is it emotional distress? Is it traumatic experiences?

In the end, all cancers are caused by interaction between the internal and the external environment – our genetic predispositions, our life history, and the external factors to which we are exposed. All these factors must be addressed and resolved, for true healing to occur.

We at the Arizona Center for Advanced Medicine are honored to share in the journey of our patients, and are always searching out new and innovative therapies, keeping our patients’ best interests at heart.

Hear from one of Arizona Center for Advanced Medicine cancer patients …

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Additional information on possible causes of bladder cancer…
Here are additional comments on bladder cancer by Dr Martha Grout M.D.(H), Arizona Center for Advanced Medicine, Scottsdale, AZ. Much has been written about the association between organ dysfunction and emotional shock, by Dr.  Ryke Geerd Hamer[1], Carolyn Myss[2], DrGroutWChristine Page and others. But the concept did not originate in the 21st century. Chinese Medicine, since its earliest recorded texts, has associated the organs with specific emotional characteristics – the Heart with mania, the Spleen with worry, the Lung with grief, the Bladder with fear, the Liver with anger.

So is bladder cancer related to not being able to “mark our territory”? Loss of power or position at work or in relationship? Fear may be a big factor in the development of bladder cancer. One of the first things that happens when we are faced with a situation of acute fear for our lives is that our bladder let’s go and we wet ourselves. It is a natural fight-or-flight response – when lions are chasing us, we do not need to be held back by the extra weight of urine. The contraction of the bladder is a reflex part of that fight-or-flight reaction. When we are chronically afraid for our lives – never sure of our security or position on the job or at home – we may well develop bladder symptoms, and even cancer, if the situation goes on long enough and other conditions are right.

 View video below “Chronic vs acute illness: Ask Dr. Martha Grout”…

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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LogoYogaJournal

Why People Don’t Heal

Myss’s core teachings revolve around releasing victim consciousness and embracing forgiveness. Observing a friend reveal, in an inappropriate context, that she was an incest survivor, Myss realized that we “show our wounds” as a way to get close to each other. “Woundology,” as she calls it, “is our first language of intimacy.” The problem with bonding this way, Myss says, is that it gives power to victim consciousness and keeps people wounded.

Recently Myss has had to work on rebuilding her own health. In 1992, two weeks after she began to wonder why people don’t heal, Myss became ill with a condition that worsened until she found herself, three years later, in a “place of incredible desperation,” saying, “I want out-I can’t deal with the pain.” She searched for guidance from, of all things, her tape “Why People Don’t Heal,” taking notes on the part about forgiveness. Realizing she needed to forgive two people in her life, she asked the gods to arrange opportunities for contact with these people. Within a few months, both conflicts came to resolution. Now, she says, “The things I’m doing to engage my health are going to start working. Because I’m playing by these rules.” “I know the gods hold me accountable to walk the way I talk,” she says. “A teacher is dishonorable who doesn’t do that.”

View the entire article with an excellent interview with medical intuitive Carolyn Myss, click here >> http://goo.gl/P4Gar.

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logoResearchGeneticCenterGermany

Research Genetic Cancer Center, GmbH, is a laboratory in Greece to which we send peripheral blood samples, specifically for the genetic analysis of circulating tumor stem cells, both for cell count and for chemo-sensitivity. The lab also measures sensitivity to botanical and other medicinal treatments used in cancer therapy. This test is not covered by insurance. The biggest difference between this laboratory and others in the United   States is the chemosensitivity testing.

Genetic testing of tumor cells is available in the United States, but so far the available tests do not appear to have the advantages of those available to us through the RGCC lab.

The CellSearch ® Circulating Tumor Cell (CTC) Test from Veridex is a blood test that assesses circulating tumor cells to give an estimate of survival of patients with metastatic breast, colorectal or prostate cancer at any time. It does not measure chemosensitivity, nor is it covered by insurance.

The Rational Therapeutics laboratory tests fresh tumor samples for chemosensitivity. This test requires tumor tissue from surgery or biopsy. It does not test circulating tumor stem cells. It is not covered by insurance.

Caris Target Now® molecular profiling identifies specific genetic mutations associated with benefit (or lack of benefit) from particular families of chemotherapeutic agents. It is a test of probability, not of chemosensitivity, and requires a tissue specimen. It is occasionally covered by insurance.

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Sources:

[1] http://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf

[2] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-survival-rates

[3] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-what-is-cancer

[4] http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-risk-factors

[5] http://www.health-science-spirit.com/hamer.html

[6] Jiao SC, Huang J, Sun Y, Lu SX. The effect of insulin on chemotherapeutic drug sensitivity   in human esophageal and lung cancer cells. Zhonghua Yi Xue Za Zhi. 2003 Feb 10;83(3):195-7.

[7] Porter HA, Carey GB, Keegan AD. Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Exp Cell Res. 2012 Aug 15;318(14):1745-58. Epub 2012 May 28.

[8] Graham NA, Tahmasian M et al. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26;8:589. doi: 10.1038/msb.2012.20.

[9] http://www.cornerstonepharma.com/cancer-metabolism/overview

[10] http://learninggnm.com/documents/hamerbio.html

[11] http://www.natural-connection.com/resource/yoga_journal/why_people_dont_heal.html

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Do you know the cost of Cancer Care? Cancer Series #19. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer19

Cancer Series #19 – Cost of Cancer Care.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

A recent news brief from the American Society of Clinical Oncology[1] was about the skyrocketing costs of cancer care. The author was discussingCancer19-ASCOlogo the cost of cancer care for people with sickness insurance, mind you. Dr. Thomas J Smith is quoted as saying: “The costs of cancer care are rising at an unsustainable rate, and the quality and value of the care is often suboptimal … Insurance premiums have doubled over the past decade, as have out-of-pocket patient costs. These unsustainable costs have resulted in 1 million health-related bankruptcies in the United States this year alone.”

Why in the world do we have so-called “health” insurance, if we still go bankrupt when we become ill?

An article published in Newsweek in August 2012[2] says: “According to figures from insurer United Healthcare, a standard cocktail of drugs for treating lung cancer used to run about $1,000 a month. Today’s regimens cost from more than $6,000 to almost $10,000—for about two more months of life.” The same article talks about the minimal extension of life – as little as two months longer median survival is considered to be a Cancer19-patientIPT“success”, a great “break-through”.  There is no mention of the quality of life, whether it is good, or whether it’s just miserable life full of side effects from the additional chemo treatments.

Patients who decide on treatment using integrative modalities and insulin potentiated chemotherapy (IPT) end up paying about as much as they would pay if they did conventional treatment, because of the deductibles, drugs not covered by their insurance, tests not covered by their insurance, etc. Their outcomes are no worse – and sometimes significantly better. Their quality of life is always significantly better.

View more information on and insulin potentiated chemotherapy (IPT), click here >> http://goo.gl/PvpCu .

Average cost of an IPT regimen (including the integrative aspects of the regimen outlined in the next paragraph) is approximately $50-60,000.00. The cost may be greater or less, depending on the cost of the chemotherapeutic agents (some are very expensive even in the small doses that we use for IPT) and whether “health” insurance covers the cost of some of the X-rays, surgical procedures (e.g. chest port insertion, cancer19-Immunedrainage of fluid from the lungs or the abdomen) and routine lab work.

In addition to IPT chemotherapy, we also do many other treatments to help to support the immune system, clean up the diet and the intestinal tract, using supplements and botanical medicines to fill in nutritional potholes and restore good metabolic function. We help our patients to locate and clear out any unfinished business they may have, on all levels, physical, emotional, mental and spiritual, in order to remove any potential blocks to healing. We provide our patients with a sense of community, and interaction with others who are also facing health challenges.

Cancer19-hands

The cost of such comprehensive care is what it is. The value of such care is priceless.

View the other Cancer Series articles, click here >> http://goo.gl/8AU1g.

View more information on the important subjects above…

View more information on the immune system, click here >> http://goo.gl/ztoHS .

View more information on the diet and the intestinal tract, click here >> http://goo.gl/MCHFT .

View more information on removing potential blocks to healing, click here >> http://goo.gl/egXtR .

View the video below on the I.P.T. process…

Sources:

[1] Piana R. Despite the Rhetoric, Cancer Care Costs Keep Skyrocketing: Is There a Solution? ASCO Post November 1, 2012, Volume 3, Issue 16

[2] The Cancer “Breakthroughs” that Cost Too Much and Do Too Little. Aug 27, 2012 1:00 AM EDT

LogoASCOpost

Despite the Rhetoric, Cancer Care Costs Keep Skyrocketing: Is There a Solution?

The consequences of changing our practice habits will result in equal or better care and sustainable growth in our delivery system. Thomas J. Smith, MD, FACP

Although health-care experts routinely agree that the rising costs of oncology services are untenable, there is disagreement about how to reduce expenditures without harming access and quality of care. At this year’s ASCO Annual Meeting, Thomas J. Smith, MD, FACP, offered some interesting ideas about how to bend the cancer care curve downward.1

Recognizing the Problem

According to Dr. Smith, to maintain our ability to deliver high-quality cancer care, the oncology community must begin bending the cost curve downward, and the first step is an honest recognition of the problem. “The costs of cancer care are rising at an unsustainable rate, and the quality and value of the care is often suboptimal,” said Dr. Smith.

Dr. Smith made the case that health care is often less than optimal with data from studies that looked at care patterns for patients with cancer. The findings he presented—such as inadequate use of hospice benefits, a lack of doctor-patient conversations about advance directives, and overuse of chemotherapy in the final weeks of life—are well documented in the literature, as is the disproportionate health-care spending in the United States compared with other Organisation for Economic Coordination and Development (OECD) nations. “We spend about $8,000 per person per year, nearly double the expenditures in Canada, which spends about $4,500 per person with equivalent or better national health-care outcomes than the United States,” said Dr. Smith.

Dr. Smith stated the hard facts: “Our yearly health-care budget is approaching $3 trillion, which is devouring our [gross domestic product]. Insurance premiums have doubled over the past decade, as have out-of-pocket patient costs. These unsustainable costs have resulted in 1 million health-related bankruptcies in the United   States this year alone.”

Value Needs to Reflect Price

Balancing value vs the cost of drugs and services is rapidly becoming a central theme in the health-care narrative. Dr. Smith gave several examples in which cost has outstripped value. “Some of the workhorse oncology drugs that have real clinical value are priced relatively inexpensively. For instance, paclitaxel and trastuzumab [Herceptin] cost less than $5,000 per month; however, some of the newer drugs such as pemetrexed [Alimta] cost about twice that at $10,000 per month. And, in the extreme cases we have drugs such as sipuleucel T [Provenge], which cost almost $100,000 for one administration,” noted Dr. Smith, adding that data show that many of the newer drugs do not add enough clinical value to warrant the sticker-shock costs.

Dr. Smith stressed that most of the spending increases are well within our control. “Based on geographic variations, the congressional budget office (CBO) estimated that upward of 30% of clinical care is not evidence-based and does not add value for the patient. Things that oncologists do have control over are the use of imaging, chemotherapy selection, supportive care services, surveillance after curative care, proper and timely use of palliative care and hospice, and avoiding unnecessary therapy and hospitalization near the end of life,” said Dr. Smith.

Behavior Modification

As Dr. Smith pointed out, part of the rise in oncology costs is driven by physicians’ practice behavior, with respect to the underuse of cost-saving interventions such as palliative care and hospice, and overuse of unwarranted services and therapies. Palliative care and hospice actually improve the quality of care, at an affordable cost. And some of the most expensive treatments are no better than things they replace; for instance, MemorialSloan-KetteringCancerCenter just elected to not cover ziv-aflibercept (Zaltrap), which costs twice as much as the comparison drug. In an effort to curb unnecessary spending, ASCO has joined the American Board of Internal Medicine in the “Choosing Wisely” campaign, which encourages medical groups to select five areas in which they can improve care and reduce costs.

Dr. Smith highlighted the ground rules for the campaign. “Everything is on the table for discussion. We need to accept data where it exists, curative and adjuvant care along with clinical trials are always exempt, and perhaps most importantly, we need to recognize that this is going to be painful,” he said.

“For instance, “ he continued, “supportive care and chemotherapy administration represent a main source of an oncologist’s income, so modifying certain practice methods to save money will ultimately reduce practice revenue—painful but necessary. Also, patients with cancer are a hefty source of hospital income; reducing hospital days will affect the institution’s bottom line.”

Another bridge to cross is the initiation of comprehensive discussions about death and medical costs, subjects that both doctors and patients traditionally shy away from. “These discussions have been shown to save money and add to a patient’s quality of life,” said Dr. Smith.

Targeting Overvalued Treatment

“The first area we targeted was aligning surveillance procedures to patients who were most likely to derive benefit. For instance, in 1990 we spent at least $1 billion in breast cancer screening [for recurrence]. Today that number is several billion dollars. However, the ASCO and National Comprehensive Cancer Network (NCCN) guidelines agree that in the absence of symptoms, there is no evidence that CEA, CA 27-29, positron-emission tomography, computed tomography, and bone scans have any value as screening tools to follow women,” said Dr. Smith.

He emphasized that screening guidelines can be reviewed in less than 10 minutes, giving doctors the opportunity to explain to their patients that these expensive screening methods have no guideline-proven benefits for their breast health. “Instead, we should stress breast care that is effective, such as timely mammograms and maintaining a healthy lifestyle. The solutions that we proposed are that payers simply should not reimburse for these tests and the ASCO Quality Oncology Practice Initiative (QOPI) committee should audit for overuse,” said Dr. Smith.

Another recommendation was to only use sequential or monotherapies in the second-line setting or later metastatic treatments. Dr. Smith explained why this approach was important. “Patients will live just as long, and they will avoid unnecessary toxicity. This will result in fewer supportive care costs, fewer hospitalizations, and will ultimately lower oncology costs. Naturally, this approach requires honest discussions about goals of care.”

Dr. Smith remarked that it is also important to limit active therapy to patients with good performance status. “A good screening question to ask is, ‘Did this patient walk unaided to the clinic?’ If a patient’s ECOG performance status is 3 or 4, a discussion of prognosis and realistic treatment expectations should ensue,” noted Dr. Smith, adding that he and his colleague Bruce E. Hillner, MD, have written extensively about dose reductions that can obviate the need for granulocyte colony-stimulating factors (G-CSF) in solid tumors.

“The United States has 3% of the world’s population, but buys 75% of the world’s G-CSF. These drugs are essential when using certain types of chemotherapy, but we have not found any trial that shows better survival rates when using G-CSF in solid tumors,” said Dr. Smith.

One other “Choosing Wisely” recommendation was to switch to nonchemotherapy palliative care after the cancer grows through two or three regimens. “Using NSCLC as an example, we see that the use of chemotherapy after two or three regimens is toxic, expensive, rarely helpful, and prevents the planning for transitions to end-of-life care, such as timely entry into hospice,” said Dr. Smith.

Conclusions

Along with ASCO’s “Choosing Wisely” recommendations, Dr. Smith stressed that we need to change payment methods from those that incentivize overuse of testing and treatment to mechanisms that reward best practices.

“Under the current fee-for-service practice, oncologists derive more than 50% of their revenue from the drugs they prescribe. I think this system will face continued pressure to change,” said Dr. Smith. “One alternative is fixed provider payment systems (ie, salaried physicians), in which physicians will trade lower revenue streams for more secure incomes. It’s important to note that the Veterans Affairs systems have equivalent outcomes to private practices while working on a fixed budget. Moreover, as a community, we eventually need to see Medicare as a scarce resource, not a profit center.”

Dr. Smith said that the oncology community could provide actionable solutions to improve both quality and cost of care by using treatments based on evidence, better end-of-life care and coordination, more standardized practice methods, using clinical pathways, and more auditing with the intent of practice change. “The consequences of changing our practice habits will result in equal or better care and sustainable growth in our delivery system,” concluded Dr. Smith.

View the entire article, click here >> http://goo.gl/IyoPj .

logoDailyBeast

Price Of Newer Cancer Drugs May Not Be Linked To Benefits.

The Daily Beast (8/27, Beil) reports, “Treating cancer has never been cheap, but today, the price of each new treatment seems to outpace the one before, with little bearing on its efficacy.” About eight years ago, “researchers tried to test the relationship between a drug’s development and its final asking price.” But, “in the Journal of Clinical Oncology, the scientists concluded ‘that the drug companies are not pricing their drugs to recuperate losses associated with research and development, marketing, and operating prices, but rather [the average wholesale price] depends on what the market itself can bear.”

LogoNewswekDailyBeast

The Cancer “Breakthroughs” that Cost Too Much and Do Too Little

‘Death panels’ are a bad idea. But asking hard questions about health care is not.

In his more than 35 years of practice, Dr. Lowell Schnipper has seen a lot of women die from breast cancer. A patient’s options start to dwindle by the time tumor cells set up outposts in the bones, lungs, and other organs, defying all attempts to keep them under control. But in June, when the government approved Perjeta, Schnipper had something new to offer. The drug is one of an innovative class of drugs known as “targeted therapies.”

As the chief of oncology at Beth Israel Deaconess Medical Center in Boston, Schnipper knew Perjeta was not a cure: combined with Herceptin—another targeted therapy that was hailed as a breakthrough in 1998—Perjeta gives the average woman only about six months of calm before her disease starts to stir again. Given the limited benefit, the price was startling. For most women, a full course of the drug combination will cost $188,000—enough, he says, “to give anybody a cold sweat.”

Americans spent more than $23 billion last year for cancer drugs, more than we paid for prescriptions to treat anything else. But many oncologists are starting to question what we are getting in return for that bill, whether the war on cancer has become too much of a race to produce the next blockbuster. “In general, progress for cancer has been halting and slow,” says David Howard of the Department of Health Policy and Management at EmoryUniversity. So far, most new drugs offer only marginal extensions of life and few cures. Howard says new so-called breakthroughs “overpromise and underdeliver.” Consider the popularity of Avastin, a targeted drug approved for metastatic colon cancer in 2004. A recent study found that almost 70 percent of patients on chemotherapy were receiving Avastin within a year of its release. In clinical trials, the drug increased survival by about five months. The cost? About $10,000 a month.

Treating cancer has never been cheap, but today, the price of each new treatment seems to outpace the one before, with little bearing on its efficacy. According to figures from insurer United Healthcare, a standard cocktail of drugs for treating lung cancer used to run about $1,000 a month. Today’s regimens cost from more than $6,000 to almost $10,000—for about two more months of life. “There is no such thing as a cancer drug coming on the market that is some sort of regular drug price,” says Dr. Peter Bach of MemorialSloan-KetteringCancerCenter in New York, who studies the impact of cancer costs on U.S. health care. “They’re all priced at spectacularly high levels.” Which leads to an unsettling question: how much is a little more time worth? Would you spend $50,000 for four more months? How about $15,000 for two weeks?

Of three frontiers in cancer treatment, targeted therapies like Perjeta are widely seen as the best hope for a cure. Traditional chemotherapy is notorious for side effects because it wields destruction indiscriminately throughout the body. Targeted therapies are designed to hit cancer cells only. Perjeta, for example, targets a protein produced in excess amounts in some breast cancers; Avastin hinders the ability of a tumor to form new blood vessels to feed itself.

Doctors envision the day when every patient will have therapy precisely matched to the genetic bull’s-eyes of their own cancers. The holdup has been that cancer has proven to be more genetically crafty than researchers once imagined. Scientists may build a drug to hit one target, but a tumor may also employ lots of yet-undiscovered genetic tricks to keep itself alive. Instead of a magic bullet, scientists now know that any particular tumor may need lots of magic bullets. With so many targets unknown, a lot of patients end up getting drugs that barely touch their cancers, which is why the effectiveness of many new drugs remains underwhelming.

Not that this keeps a drug from becoming a blockbuster. Patients with advanced cancer, and their physicians, are hungry for progress. As a result, almost all of the 10 bestselling cancer drugs are targeted therapies, many less than a decade old. All came on the market at thousands of dollars a month, a trend that continues today with gusto. The drug Afinitor, a daily pill, was approved in July for patients with breast cancer. It costs more than $200 a tablet. But price rarely matters to patients or even doctors, says Dr. Oliver Sartor, medical director of the TulaneCancerCenter in New Orleans. “People have already been told there is no cure for their disease,” he says. “Every increment, every improvement, gives hope, and when options are extremely limited, we all focus on the positive possibilities.”

View the entire article, click here >> http://goo.gl/IccDF .

Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Integrative Cancer Care. Cancer Series #18. Featured by the Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical cancer treatment in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer18

The Exclusive Cancer Series #18 – Integrative Cancer Care.

Important information cancer patients and their families should know.

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

Chemo, surgery, radiation – this is the mantra of current recommendations for cancer therapy. Treatment options on the website of the Mayo Cancer18-BestAnswerLogoClinic, “the most innovative, progressive care anywhere” are the following: bone marrow transplantation, chemotherapy, radiation therapy and radio frequency ablation.[1]

And yet… the incidence of cancer is projected to rise 75% by the year 2030.[2] What is wrong with this picture?

Insulin potentiation chemotherapy, low dose

The National Cancer Institute describes side effects of conventional chemotherapy on its website.[3]Cancer18-vomit

Some common side effects from chemotherapy are fatigue, nausea, vomiting, decreased blood cell counts, hair loss, mouth sores, and pain… Sometimes, chemotherapy causes long-term side effects that do not go away. These may include damage to your heart, lungs, nerves, kidneys, or reproductive organs. Some types of chemotherapy may cause a second cancer years later.

The website does not mention death from destruction of the immune system and systemic infection.

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View an entire article on Insulin potentiation chemotherapy at our website, click here >> http://goo.gl/gaXOZ .

Chemotherapy is actually pretty effective for a few cancers.4 Greater than 10% survival can be attributed to cytotoxic chemotherapy in the following cancers: cervix 12%, ovary 8.7%, testicle 41.8%, Non-Hodgkins Lymphoma 10.8%, Hodgkins Lymphoma 35.8%. Breast cancer gets only 1.5% survival increase from chemotherapy, colon cancer 1.8%, brain cancer 4.9%.

Why are we so quick to put conventional chemotherapy first on the list for cancer treatment? Graeme Morgan, an Australian radiation oncologist, writes: “For most patients, the use of cytotoxic chemotherapy is for the palliation of symptoms and to improve quality of life.” However, Dr. Morgan concludes: ““The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.” [1]

If conventional chemotherapy were less toxic, it might be worth it. But for a 2.5% benefit? It is hard to discern the advantages.

Most people are not aware that there is a gentler form of chemotherapy, known as Insulin Potentiation Therapy, low dose.[2],[3] This therapy is just as effective as standard chemo, without all the painful and sometimes lethal side effects. Insulin is used to lower the blood sugar, resulting in relatively increased starvation of cancer cells which require more sugar than normal body cells. Once the blood sugar is sufficiently low, sugar is given intravenously, along with a small dose of chemo (about 10-15% the usual dose). The chemo is sucked into the cells, along with the sugar, and concentrates in cancer cells because they are so much more avid for sugar than normal cells.[4],[5]

With IPT, the incidence of so-called side effects is markedly decreased. Most of our patients drive themselves home from treatment. They may report a little fatigue on the day of treatment. Seldom do they lose any hair at all, and they hardly ever drop their white blood cell counts. They are able to lead normal lives during the course of their IPT therapy.

View the FREE video below describing I.P.T. therapy at Arizona Center for Advanced Medicine…

If our therapies are so effective, why is the incidence of cancer projected to rise so dramatically? And why are the therapies in fact not effective Cancer18-Fig1for every form of cancer?

Our bodies are full of toxins – chemicals from our foods and from the air we breathe, artificial colorings and flavorings, artificial sweeteners (like chlorinated hydrocarbons, or pesticides), high levels of sugar with consequent high levels of insulin, or even frank diabetes. So it is not surprising that mutations can occur. That is the essence of cancer. The cells mutate to a lower state of being, one where they are only concerned with growth, and not with the good of the entire organism.

Insulin Potentiation Therapy – even low dose – is NOT ENOUGH to treat cancer, any more than chemotherapy by itself is a sufficient treatment. For truly integrative cancer therapy, many different modalities are brought into play.

It is helpful to know which chemotherapy to use – which actually kills your cancer cells, not just which has been studied and had a good effect on 30% or 50% of people in whom it was tried. It is equally helpful to know which complementary – botanical and supplemental – therapies could be therapeutic.

Chemosensitivity testing is available – but not in these United States, unfortunately.  We use a laboratory in Greece, run by an oncologist, to determine which drugs and which supplements to use for the greatest effect. 

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View more information on the Greek RESEARCH GENETIC CANCER CENTRE LTD methods, click here >> cancer18-Fig2http://goo.gl/hEh1F , and scroll about half way down the page.

  • We use standard chemotherapeutic agents – and sometimes even standard combinations as recommended in the current oncology literature.[1]
  • We use botanical remedies like Iscador[2], and supplements like high dose Vitamin C[3] (but not if bortezomib is part of the regimen chosen[4], lipoic acid[5], glutathione[6] and many others, to restore the function of natural killer cells, and to bring the body back to a state where it can defend itself against the foreign cancer cell invaders.
  • We teach our patients the basics of a healthy diet – encouraging mainly plant-based foods[7] in  the early phases.
  • We test for nutrient deficiencies, and administer nutrient IV therapies to replenish the body’s stores.Cancer18-Fig3
  • We work with our patients to help them dismantle barriers to healing – old dogma, old conflicts, old beliefs, old injuries, physical or emotional, which they have been unable to see or unwilling to give up.

View more information on the Arizona Center for Advanced Medicine website…

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View more information on basics of a healthy diet, click here >> http://goo.gl/HrAjT .

View more information on nutrient IV therapies, click here >> http://goo.gl/2usMN .

View more information to dismantle barriers to healing, old beliefs, click here >> http://goo.gl/nUdhX .

Cancer18-beliefLEFT

As with any medical therapy, it is unwise to throw out everything, because each form of therapy has its use. Chemotherapy does indeed kill many cancer cells. High dose Vitamin C kills many others. Anti-inflammatory supplements and spices help to restore balance to the immune system. Cancer18-textgraphicNutrients help to sustain the body in its battle. And release of old stuff helps to restore the soul to a place of gratitude and love.

Every modality plays a part in our therapies. We are honored to share the journey with our patients. We would prefer to share the journey earlier in its course rather than later, when the immune system is already gone, and the body is in desperate straits.

Standard chemotherapy is like a bomb exploding, creating collateral damage to the organism.

Insulin Potentiation Therapy, when combined with Integrative and Functional Medicine Therapy, is a lifeline to help restore physical function and enable the body to heal.

Hear from an actual Cancer patient in the video below…

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For more information about our integrative cancer care, please visit the website, click here >> http://goo.gl/oMoAu.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

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Sources:

[1] Downloaded 12/2/2012 from http://www.mayoclinic.org/cancer-treatment/diseases.html

[2] Bray F, Jemal A, Forman D et al. Global cancer transitions according to the Human Development Index (2008—2030): a population-based study. The Lancet Oncology, Volume 13, Issue 8, Pages 790 – 801, August 2012

[3] Downloaded 12/2/2012 from http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you/page5

[4] Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.

[5] http://www.arizonaadvancedmedicine.com/therapies/IPT_therapy.html

[6] http://www.bestanswerforcancer.org/what-is-insulin-potentiation-therapy-low-dose-iptld/

[7] Raffaghello L, Safdie F, Longo VD et al. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15;9(22):4474-6.

[8] Lee DH, Raffaghello L, Longo VD et al. Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Sci Transl Med 7 March 2012: Vol. 4, Issue 124, p. 124 – 27

[9] Chu E, DeVita VT. Physicians’ Cancer Chemotherapy Drug Manual (updated every year). © Jones & Bartlett Learning, LLC. ISBN 978-1-4496-4683-7.

[10] Strüh CM, Jäger S, Martin SF et al. A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells. Phytother Res. 2012 Feb 8. doi: 10.1002/ptr.4604.

[11] Frei B, Lawson S. Vitamin C and Cancer Revisited. PNAS August 12, 2008 vol. 105 no. 32

[12] Perrone G, Hideshima T, Anderson KC et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia. 2009 Sep;23(9):1679-86.

[13] Zachar Z, Marecek J, Bingham PM et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

[14] Singh S, KhanAR, GuptaAK. Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol. 2012;9(4):303-16.

[15] Campbell TC, Campbell II TM. The China Study. © 2006, BenBella Books. ISBN 978-1932100-66-2

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Give the Arizona Center for Advanced Medicine Scottsdale Cancer Center a call to schedule a time to come see us, visit our new beautiful expanded cancer clinic, ask lots of questions, and make an informed decision for good health. For more information on us, read  ‘About Us’, click here >> http://goo.gl/eKQu6.

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The Arizona Center for Advanced Medicine treats over 300+ conditions. Contact Arizona Center for Advanced Medicine for a FREE consultation at 480-240-2600, or click here >>http://goo.gl/R2cGE.

Make an APPOINTMENT ONLINE, Fast and Easy, click here >> http://goo.gl/p2lnZ.

Review real patient testimonials and videos, click here >> http://goo.gl/hANEh.

Thank you for viewing the Arizona Center for Advanced Medicine Cancer blog. We want your OPINION, please take just one minute to VOTE, click here >>http://goo.gl/JnzMT.

Order Dr Martha Grout’s new book “An Alphabet of Good Health in a Sick World”  and view more information on this featured book and how to ORDER with a special offer, click here >>  http://goo.gl/lgwqi.

Hear Dr. Grout’s radio show interview on “Good Health in a Sick World”, (the actual interview starts at 4:14 minutes) click here >> http://goo.gl/gnihJ.

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Find, Follow, LIKE and See us everywhere at ‘AdvancedCancerAZ’.


Inflammation and Cancer – is there a link? Cancer Series # 17. Featured by Arizona Center for Advanced Medicine Cancer Center. Providing integrated medical treatment for cancer in Scottsdale (Phoenix), AZ. Call 480-240-2600.

Cancer17

Cancer Series #17 – Inflammation and Cancer – is there a link?

Submitted by as part of the ‘Exclusive Cancer Series’ of articles by Dr. Martha Grout, M.D., M.D.(H) at the Arizona Center for Advanced Medicine Cancer Center, Scottsdale (Phoenix), Az.

An excellent definition of oxidative comes out of a review paper published in 2010 on the National Institutes of Health (NIH) website:

Oxidative stress is defined as an imbalance between production of free radicals and reactive metabolites, so-called oxidants or reactive oxygen species (ROS), and their elimination by protective mechanisms, referred to as antioxidants. [1]

Electron transfer to oxygen occurs at the level of the electron transport chain in the cell membranes of the mitochondria – the little structures within the cell which produce our energy and help us dispose of our cellular waste (free electrons) as long as we provide them with the appropriate trash cans to dispose of the wastes. These trash cans are called anti-oxidants.

Under conditions of sustained stress, and depletion of anti-oxidants, the mitochondrial electron transport chain becomes overwhelmed.

Some level of ROS is a perfectly normal state of affairs within the cell, producing molecules which let the body know that trash-collection is Cancer17membraneneeded, ROS being the normal end-product of cellular metabolism. “… aerobic cells produce ROS such as superoxide anion (O2-), hydrogen peroxide (H2O2), hydroxyl radical (OH•), and organic peroxides as normal products of the biological reduction of molecular oxygen”.[2]

A little ROS stimulates the call for anti-inflammatory molecules. A lot of ROS is, on the other hand, quite damaging to the body. Excessive ROS stimulates growth factors, cell cycle regulators, and more damaging types of ROS which can in fact alter or destroy mitochondrial DNA, and eventually the DNA of the cell itself.

Initiation of cancer has been linked to this form of DNA damage.[3] Protection against such damage is provided by several enzymes – superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, catalase – as well as anti-oxidant substances like glutathione (GSH), Vitamin C, and Vitamin D.

Rudolf Virchow first noted in 1863, that inflammatory cells are present within tumors, and that tumors appear to arise at the site of chronic inflammation.[4] The link between ulcerative colitis and colon cancer is well established, with “cumulative probabilities of [development of colon cancer of] 2% by 10 years, 8% by 20 years, and 18% by 30 years”.[1]

Tumor-associated macrophages are a major component of almost all tumors.[2] Macrophages are essential cells for wound healing, and tumors Cancer17-cellshave been described as “wounds that never heal”.  Tumors appear to co-opt the wound healing process, and turn it into a wound-perpetuating process – as has been demonstrated in the zebrafish embryo. [3]

Now, finally, it begins to make sense that emotional wounds can also be linked with cancer development. If we believe in the concept of “as above, so below”, if we truly understand that our minds, our emotions and our bodies are not separate entities, but one living organism, then finally we begin to connect the dots between the intolerable situation we experienced as a child, and which we never expressed or discharged, and the colon cancer which developed in the organ the body uses to discharge its wastes.

A review of PubMed using the search terms “emotional wound”, “forgiveness”, and “cancer“ brought up no articles relevant to the emotional LogoPubMedaspect of the wound, but plenty of articles about the emotional aspects of dealing with a diagnosis of cancer. Using the search terms “forgiveness” and “stress” brought up 60 articles, but only one article related to cancer[4] – and that article talked about self-forgiveness after the diagnosis was already made.

A Google search using the same terms brought up over 2 million hits. Fox News has a segment with Dr. Michael Barry, who discusses the relationship between the immune system and stress, which he relates to lack of forgiveness.[5]  He likens it to trying to drive a car with the parking brake on – dragging around a lot of excess baggage. He is careful to note that there is no research on the subject – but at least he discusses the concept.

So, if we can buy the concept that psychological stress causes inflammation on the physical level, then it’s not too far a leap to the place where finding something “impossible to swallow” results eventually in cancer of the throat or the esophagus, where being “suffocated by a relationship” leads to asthma or lung cancer, where being unable to let go of something results in irritable bowel syndrome, constipation, ulcerative colitis or colon cancer.

At the Arizona Center for Advanced Medicine, not only do we treat the body with therapies that help heal the physical illness, we also make every effort to help our patients make these stress-linked connections, so that they can heal on all levels.

Hear from an actual Arizona Center for Advanced Medicine cancer patient in the video below, or click here for video channel version >> http://goo.gl/uQk1k.

View the other Exclusive Cancer Series articles, click here >> http://goo.gl/8AU1g.

Sources:

[1] Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001 Apr;48(4):526-35.

[2] Liguori, M.; Solinas, G.; Germano, G.; Mantovani, A.; Allavena, P. Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma. Cancers 2011, 3, 3740-3761.

[3] Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P (2010) Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biol 8(12): e1000562. doi:10.1371/journal.pbio.1000562

[4] Romero C, Friedman LC, Kalidas M, Elledge R, Chang J, Liscum KR. Self-forgiveness, spirituality, and psychological adjustment in women with breast cancer. J Behav Med. 2006 Feb;29(1):29-36. Epub 2005 Dec 15.

[5] http://video.foxnews.com/v/1217030696001/is-cancer-linked-to-not-forgiving/

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More information throughout our Arizona Center for Advanced Medicine sites…

View “FOOD 101 – Genetics, Addiction, and Politics” Click here >> http://goo.gl/HE7lJ .

View FOOD 201 – Is Organic Really Better?” Click here >> http://goo.gl/onbvN .

View Insulin Potentiation Therapy for Cancer” Click here >> http://goo.gl/twLvk .

View several articles on GMO Food. Click here >> http://goo.gl/yx0YT .

View VideoInsulin Potentiation Therapy for Cancer” Click here >> http://goo.gl/Bl3fm .

View video of a discussion with an Arizona Center for Advanced Medicine patient, click here >> http://goo.gl/Hh08V .

We have included below some additional informative support articles…

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Oxidative stress, inflammation, and cancer: how are they linked?

Source

Department of Experimental Therapeutics, The University of Texas MD AndersonCancerCenter, Houston, TX77030, USA.

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Abstract

Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary diseases. Oxidative stress can activate a variety of transcription factors including NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2. Activation of these transcription factors can lead to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules. How oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell, tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis, and stem cell survival is the focus of this review. Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.

View the complete article, click here >> http://goo.gl/3G2dT .

LogoPubMed

New insights on oxidative stress in cancer.

Source

CEINGE Biotecnologie Avanzate, via Comunale Margherita 482, 80145 Naples, Italy.

Abstract

Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed.

View the complete article at PubMed, click here >> http://goo.gl/lxPEx .

LogoPubMed

The risk of colorectal cancer in ulcerative colitis: a meta-analysis.

Source

Gastrointestinal Research Unit, LeicesterGeneralHospital

Abstract

BACKGROUND AND AIMS:

Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have investigated this risk and reported widely varying rates.

METHODS:

A literature search using Medline with the explosion of references identified 194 studies. Of these, 116 met our inclusion criteria from which the number of patients and cancers detected could be extracted. Overall pooled estimates, with 95% confidence intervals (CI), of cancer prevalence and incidence were obtained using a random effects model on either the log odds or log incidence scale, as appropriate.

RESULTS:

The overall prevalence of CRC in any UC patient, based on 116 studies, was estimated to be 3.7% (95% CI 3.2-4.2%). Of the 116 studies, 41 reported colitis duration. From these the overall incidence rate was 3/1000 person years duration (pyd), (95% CI 2/1000 to 4/1000). The overall incidence rate for any child was 6/1000 pyd (95% CI 3/1000 to 13/1000). Of the 41 studies, 19 reported results stratified into 10 year intervals of disease duration. For the first 10 years the incidence rate was 2/1000 pyd (95% CI 1/1000 to 2/1000), for the second decade the incidence rate was estimated to be 7/1000 pyd (95% CI 4/1000 to 12/1000), and in the third decade the incidence rate was 12/1000 pyd (95% CI 7/1000 to 19/1000). These incidence rates corresponded to cumulative probabilities of 2% by 10 years, 8% by 20 years, and 18% by 30 years. The worldwide cancer incidence rates varied geographically, being 5/1000 pyd in the USA, 4/1000 pyd in the UK, and 2/1000 pyd in Scandinavia and other countries. Over time the cancer risk has increased since 1955 but this finding was not significant (p=0.8).

CONCLUSIONS:

Using new meta-analysis techniques we determined the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children. We found a non-significant increase in risk over time and estimated how risk varies with geography.

View the entire article, click here >> http://goo.gl/3B91d .

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Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma

Abstract: Tumor-Associated Macrophages (TAM) are key components of the reactive stroma of tumors. In most, although not all cancers, their presence is associated with poor patient prognosis. In addition to releasing cytokines and growth factors for tumor and endothelial cells, a distinguished feature of TAM is their high-rate degradation of the extra-cellular matrix. This incessant stroma remodelling favours the release of matrix-bound growth factors and promotes tumor cell motility and invasion. In addition, TAM produce matrix proteins, some of which are typical of the neoplastic tissues. The gene expression profile of TAM isolated from human tumors reveals a matrix-related signature with the up-regulation of genes coding for different matrix proteins, as well as several proteolytic enzymes. Among ECM components are: osteopontin, osteoactivin, collagens and fibronectin, including also a truncated isoform of fibronectin termed migration stimulation factor. In addition to serve as structural proteins, these matrix components have key functions in the regulation of the vessel network, in the inductionof tumor cell motility and degradation of cellular debris. Among proteolytic enzymes are: matrix metalloproteases, cathepsins, lysosomal and ADAM proteases, and the urokinase-type plasminogen activator. The degrading activity of TAM, coupled to the production of bio-active ECM proteins, co-operate to the build-up and maintenance of an inflammatory micro-environment which eventually promotes tumor progression.

View the entire article, click here >> http://goo.gl/jlvLE .

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Cancer cells dupe the body’s immune system

Cancers may be wounds that never heal, suggest the first live images of tumours forming.

It seems individual cancer cells send out the same distress signals as wounds, tricking immune cells into helping them grow into tumours. The finding suggests that anti-inflammatory drugs could help to combat or prevent cancer.

“Lifelong, if you take a small quantity of something that suppresses inflammation, such as aspirin, it could reduce the risk of cancer,” says Adam Hurlstone of the University of Manchester, UK.

When tissue is wounded or infected it produces hydrogen peroxide. White blood cells called leukocytes are among the first cells to react to this trigger, homing in to kill the infectious agent, clean up the mess and rebuild damaged tissue. At first, the tissue becomes inflamed, but this subsides as the wound is cleared and rebuilding continues.

Now, a study in zebra fish shows that this process is also instigated and sustained by tumour cells.

Hurlstone and colleagues genetically engineered zebra fish so that skin cells and leukocytes would glow different colours under ultraviolet light. Some zebra fish were also engineered to have cancerous skin cells.

The team found that the cancerous skin cells secreted hydrogen peroxide, summoning leukocytes which helped them on their way to becoming a tumour. When the team blocked hydrogen peroxide production in the zebra fish, the leukocytes were no longer attracted to cancerous cells and the cancer colonies reduced in number.

More alarmingly, the researchers found that healthy skin cells adjacent to the cancerous ones also produced hydrogen peroxide, suggesting that cancer cells somehow co-opt them into triggering inflammation.

View the entire article, click here >> http://goo.gl/vJwo9 .

LogoPLOS

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

Abstract

It has not previously been possible to live image the earliest interactions between the host environment and oncogene-transformed cells as they initiate formation of cancers within an organism. Here we take advantage of the translucency of zebrafish larvae to observe the host innate immune cell response as oncogene-transformed melanoblasts and goblet cells multiply within the larval skin. Our studies indicate activation of leukocytes at very early stages in larvae carrying a transformed cell burden. Locally, we see recruitment of neutrophils and macrophages by 48 h post-fertilization, when transformed cells are still only singletons or doublets, and soon after this we see intimate associations between immune and transformed cells and frequent examples of cytoplasmic tethers linking the two cell types, as well as engulfment of transformed cells by both neutrophils and macrophages. We show that a major component of the signal drawing inflammatory cells to oncogenic HRASG12V-transformed cells is H2O2, which is also a key damage cue responsible for recruiting neutrophils to a wound. Our short-term blocking experiments show that preventing recruitment of immune cells at these early stages results in reduced growth of transformed cell clones and suggests that immune cells may provide a source of trophic support to the transformed cells just as they do at a site of tissue repair. These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds.

Author Summary

The translucency of zebrafish larvae allows us to live image the earliest dynamic interactions between host innate immune cells and oncogene-transformed cell clones as they first establish themselves as the precursors of full-blown cancer. These early associations manifest via cytoplasmic tethers between an immune cell and a transformed cell, and occasional phagocytic engulfment. Immune cells are first attracted to transformed cells at surprisingly early stages, before transformed cells have had a chance to form clones and are thus still singletons or doublets. We show that the key attractant is hydrogen peroxide (H2O2), which was also recently shown to be the essential early damage signal responsible for drawing neutrophils to wounds. Tissue transplantation experiments allow us to test which cells are responsible for generating the H2O2 attractant, and we show that both transformed cells and their otherwise healthy neighbors contribute. Blocking H2O2 synthesis, either pharmacologically or by morpholino-mediated knockdown of DUOX, the enzyme responsible for H2O2 synthesis in larval skin, very significantly reduces the numbers of neutrophils and macrophages drawn to transformed cell clones, and this results in reduced numbers of transformed cells, suggesting that innate immune cells play a trophic and/or support role in early transformed cell growth.

View the entire article, click here >> http://goo.gl/2U9T4 .

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Self-forgiveness, spirituality, and psychological adjustment in women with breast cancer.

Source

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA. romeroc@bcm.tmc.edu

Abstract

We evaluated whether a self-forgiving attitude and spirituality were related to psychological adjustment among 81 women being treated for breast cancer at a medical oncology clinic in a county general hospital. Both a self-forgiving attitude and spirituality were unique predictors of less mood disturbance and better quality of life (p’s < 0.001). These results are consistent with previous research that has demonstrated a positive relationship between spirituality and well-being. The findings also suggest that self-forgiveness should be explored experimentally to determine whether it can protect against the psychological effects of breast cancer-related stress. Interventions targeting these characteristics could improve the quality of life and alleviate stress, especially in women with breast cancer in public sector settings.

View the entire article, click here >> http://goo.gl/3xRtA .

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